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    Methods of Making Fused Ring Compounds
    2.
    发明申请
    Methods of Making Fused Ring Compounds 有权
    制备稠环化合物的方法

    公开(公告)号：US20170050909A1

    公开(公告)日：2017-02-23

    申请号：US15344919

    申请日：2016-11-07

    Applicant: Transitions Optical, Inc.

    Inventor： Meng He ,  Anil Kumar

    IPC: C07C39/17 ,  C07C51/353 ,  C07D307/33 ,  C07D311/94

    CPC classification number: C07C39/17 ,  C07C37/11 ,  C07C41/01 ,  C07C51/353 ,  C07C2602/08 ,  C07C2603/40 ,  C07D307/33 ,  C07D311/94 ,  C07D405/04 ,  C07D407/04

    Abstract: The present invention relates to methods of making fused ring compounds, such as indeno-fused naphthols, and fused ring indenopyran compounds, such as indeno-fused naphthopyrans, that each employ an unsaturated compound represented by the following Formula II. Referring to the unsaturated compound of Formula II: Ring-A can be selected from optionally substituted aryl (e.g., phenyl); m can be, for example, from 0 to 4; R1 for each m can be selected from optionally substituted hydrocarbyl (e.g., C1-C6 alkyl) optionally interrupted with at least one linking group (e.g., —O—); and R3 and R16 can each be independently selected from, for example, hydrogen or optionally substituted hydrocarbyl, such as C1-C8 alkyl. When Ring-A is a phenyl group, the unsaturated compound represented by Formula II can be referred to as an unsaturated indanone acid/ester compound, or an indenone acid/ester compound (depending on whether R16 is hydrogen, or an optionally substituted hydrocarbyl group).

    Abstract translation: 关于式II的不饱和化合物：环-A可以选自任选取代的芳基（例如苯基）; m可以是例如0至4; 每个m的R 1可以选自任选被至少一个连接基团（例如-O-）中断的任选取代的烃基（例如C 1 -C 6烷基）; 并且R 3和R 16各自独立地选自例如氢或任选取代的烃基，例如C 1 -C 8烷基。 当环A是苯基时，由式II表示的不饱和化合物可以称为不饱和茚酮酸/酯化合物或茚酮酸/酯化合物（取决于R 16是氢还是任选取代的烃基 ）。

    Process for preparing 2,2′-biphenols using selenium dioxide
    3.
    发明授权
    Process for preparing 2,2′-biphenols using selenium dioxide 有权
    使用二氧化硒制备2,2'-联苯酚的方法

    公开(公告)号：US09517986B2

    公开(公告)日：2016-12-13

    申请号：US14719900

    申请日：2015-05-22

    Applicant: Evonik Degussa GmbH

    Inventor： Katrin Marie Dyballa ,  Robert Franke ,  Dirk Fridag ,  Siegfried R. Waldvogel ,  Thomas Quell ,  Michael Mirion

    IPC: C07C37/11

    CPC classification number: C07C37/11 ,  C07C39/15

    Abstract: A process for preparing a 2,2′-biphenol, proceeds by a) adding a first phenol to a reaction mixture, b) adding a second phenol to the reaction mixture, c) adding selenium dioxide to the reaction mixture, d) adding an acid having a pKa in the range from 0.0 to 5.0 to the reaction mixture, and e) heating the reaction mixture such that the first phenol and the second phenol are converted to said 2,2′-biphenol.

    Abstract translation: 制备2,2'-联苯酚的方法是由a）向反应混合物中加入第一酚，b）向反应混合物中加入第二酚，c）向反应混合物中加入二氧化硒，d） 对反应混合物具有0.0-5.0的pKa的酸，以及e）加热反应混合物使得第一酚和第二酚被转化成所述的2,2'-联苯酚。

    Process for preparing extra pure 2, 6-diisopropyl phenol
    5.
    发明授权
    Process for preparing extra pure 2, 6-diisopropyl phenol 有权
    制备纯的2,6-二异丙基苯酚的方法

    公开(公告)号：US08664452B2

    公开(公告)日：2014-03-04

    申请号：US13578456

    申请日：2010-08-10

    Applicant: Kirti Prakash Jain ,  Dhananjay Uddhavrao Edaki ,  Harpreet Singh Minhas ,  Gurpreet Singh Minhas

    Inventor： Kirti Prakash Jain ,  Dhananjay Uddhavrao Edaki ,  Harpreet Singh Minhas ,  Gurpreet Singh Minhas

    IPC: C07C39/00

    CPC classification number: C07C37/11 ,  A61K31/05 ,  C07C37/50 ,  C07C51/353 ,  C07C51/48 ,  C07C39/06 ,  C07C63/04

    Abstract: Disclosed herein is a process for the preparation of highly pure 2,6-diisopropyl phenol (Formula I), which comprises reacting p-hydroxy benzoic acid (Formula II) with an alkylating agent in presence of aq. mineral acid followed by basification and subsequent washings to yield 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) free of dimer impurity, 4,4′-oxydibenzoic acid of Formula IV, ether impurity 3,5-di(propan-2-yl)-4-(propan-2-yloxy)benzoic acid of Formula V and the monoalkylated impurity 4-hydroxy-3-(propan-2-yl)benzoic acid of Formula VI; and decarboxylating 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) in presence of high boiling solvent and sodium hydroxide as a catalyst at high temperature to yield 2,6-diisopropyl phenol substantially free of ether impurity 1,3-di(propan-2-yl)-2-(propan-2-yloxy)benzene of Formula VII and monoalkylated phenol impurity 2-(propan-2-yl) phenol of Formula VIII. Propofol prepared by the process of the present invention is suitable for pharmaceutical use.

    Abstract translation: 本文公开了一种制备高纯度2,6-二异丙基苯酚（式I）的方法，其包括在水溶液存在下使对羟基苯甲酸（式II）与烷基化剂反应。 无机酸，随后碱化并随后洗涤，得到不含二聚物杂质的4-羟基-3,5-二异丙基苯甲酸（式III），式IV的4,4'-氧联苯甲酸，醚杂质3,5-二（丙 - 吡啶-2-基）-4-（丙-2-炔基氧基）苯甲酸和式VI的单烷基化杂质4-羟基-3-（丙-2-基）苯甲酸; 和在高沸点溶剂和氢氧化钠作为催化剂的高温存在下脱羧4-羟基-3,5-二异丙基苯甲酸（式III），得到基本上不含醚杂质的二异丙基苯酚1,3-二（ 丙-2-基）-2-（丙-2-炔基氧）苯和式VIII的单烷基化苯酚杂质2-（丙-2-基）苯酚。 通过本发明的方法制备的异丙酚适用于药物用途。

    Optically active 2,2′-biphenol derivative and production method of same
    6.
    发明授权
    Optically active 2,2′-biphenol derivative and production method of same 有权
    光活性2,2'-联苯酚衍生物及其制备方法

    公开(公告)号：US08283501B2

    公开(公告)日：2012-10-09

    申请号：US12811805

    申请日：2009-01-06

    Applicant: Yoshikazu Ito ,  Yasushi Kubota ,  Tsutomu Inoue

    Inventor： Yoshikazu Ito ,  Yasushi Kubota ,  Tsutomu Inoue

    IPC: C07C39/15 ,  C07C37/68 ,  C07C37/86

    CPC classification number: C07B57/00 ,  C07B2200/07 ,  C07C37/00 ,  C07C37/11 ,  C07C37/50 ,  C07C39/367 ,  C07C39/15

    Abstract: Disclosed herein are optically active biphenol derivatives represented by the following formulas (1) and (2), a method for optically resolving a biphenol derivative represented by formula (2′), a production method of an optically active biphenol derivative (1) comprising a step for reacting a Brønsted acid with a biphenol derivative (2), and a production method of an optically active biphenol derivative (3) comprising a step for reacting a Lewis acid with an optically active biphenol derivative (1) or an optically active biphenol derivative (2).

    Abstract translation: 本文公开了由下式（1）和（2）表示的光学活性联苯酚衍生物，用于光学拆分由式（2'）表示的联苯酚衍生物的方法，光学活性联苯酚衍生物（1）的制备方法，其包含 使布朗斯台德酸与联苯酚衍生物（2）反应的步骤和光学活性联苯酚衍生物（3）的制备方法包括使路易斯酸与光学活性联苯酚衍生物（1）或光学活性联苯酚衍生物 （2）。

    METHODS OF MAKING FUSED RING COMPOUNDS
    7.
    发明申请
    METHODS OF MAKING FUSED RING COMPOUNDS 有权
    熔融环化合物的制备方法

    公开(公告)号：US20120157678A1

    公开(公告)日：2012-06-21

    申请号：US13314735

    申请日：2011-12-08

    Applicant: Meng He ,  Anil Kumar

    Inventor： Meng He ,  Anil Kumar

    IPC: C07C37/20 ,  C07C59/86 ,  C07D311/94 ,  C07C41/30 ,  C07D413/10

    CPC classification number: C07C39/17 ,  C07C37/11 ,  C07C41/01 ,  C07C51/353 ,  C07C2602/08 ,  C07C2603/40 ,  C07D307/33 ,  C07D311/94 ,  C07D405/04 ,  C07D407/04

    Abstract: The present invention relates to methods of making fused ring compounds, such as indeno-fused naphthols, and fused ring indenopyran compounds, such as indeno-fused naphthopyrans, that each employ an unsaturated compound represented by the following Formula II. Referring to the unsaturated compound of Formula II: Ring-A can be selected from optionally substituted aryl (e.g., phenyl); m can be, for example, from 0 to 4; R1 for each m can be selected from optionally substituted hydrocarbyl (e.g., C1-C6 alkyl) optionally interrupted with at least one linking group (e.g., —O—); and R3 and R16 can each be independently selected from, for example, hydrogen or optionally substituted hydrocarbyl, such as C1-C8 alkyl. When Ring-A is a phenyl group, the unsaturated compound represented by Formula II can be referred to as an unsaturated indanone acid/ester compound, or an indenone acid/ester compound (depending on whether R16 is hydrogen, or an optionally substituted hydrocarbyl group).

    Abstract translation: 本发明涉及使稠合环化合物如茚并稠合的萘酚和茚并稠合的萘并吡喃化合物，如茚并稠合的萘并吡喃，各自使用由下式II表示的不饱和化合物的方法。 关于式II的不饱和化合物：环-A可以选自任选取代的芳基（例如苯基）; m可以是例如0至4; 每个m的R 1可以选自任选被至少一个连接基团（例如-O-）中断的任选取代的烃基（例如C 1 -C 6烷基）; 并且R 3和R 16各自独立地选自例如氢或任选取代的烃基，例如C 1 -C 8烷基。 当环A是苯基时，由式II表示的不饱和化合物可以称为不饱和茚酮酸/酯化合物或茚酮酸/酯化合物（取决于R 16是氢还是任选取代的烃基 ）。

    PROCESS FOR PRODUCING TRIPHENYLENE COMPOUND AND CRYSTAL OBTAINED BY THE PROCESS
    8.
    发明申请
    PROCESS FOR PRODUCING TRIPHENYLENE COMPOUND AND CRYSTAL OBTAINED BY THE PROCESS 有权
    用于生产三苯乙烯化合物的方法和由该方法获得的晶体

    公开(公告)号：US20110201845A1

    公开(公告)日：2011-08-18

    申请号：US13044975

    申请日：2011-03-10

    Applicant: Daisuke Takano ,  Tomokazu Kato ,  Toshihiro Fujinaka ,  Kazunori Sakamoto

    Inventor： Daisuke Takano ,  Tomokazu Kato ,  Toshihiro Fujinaka ,  Kazunori Sakamoto

    IPC: C07C39/14

    CPC classification number: C07C39/12 ,  C07B2200/13 ,  C07C37/11 ,  C07C37/84 ,  C07C2603/42 ,  Y02P20/55

    Abstract: An object of the present invention is to provide a process for producing high-purity hydroxytriphenylenes in which not only inexpensive raw materials can be used but also no complicated steps of deprotection such as dealkylation, and reduction and the like are necessary, and which is thereby advantageous in industrial production. Also there is provided a novel crystal of 2,3,6,7,10,11-hexahydroxytriphenylene monohydrate, which has satisfactory thermal stability. The process for producing a compound represented by the general formula (2) is characterized by reacting a compound represented by the general formula (1) in the presence of a metal oxide comprising a metal selected from trivalent iron, pentavalent vanadium and hexavalent molybdenum and of a nonvolatile strong acid: wherein, Rs are each independently a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms or an alkoxy group having 1 to 3 carbon atoms.

    Abstract translation: 本发明的目的是提供一种生产高纯度羟基三苯并噻吩的方法，其中不仅可以使用便宜的原料，而且还不需要复杂的脱保护步骤如脱烷基化和还原等，从而 有利于工业生产。 还提供了具有令人满意的热稳定性的2,3,6,7,10,11-六羟基三亚苯一水合物的新晶体。 由通式（2）表示的化合物的制备方法的特征在于使通式（1）表示的化合物在包含选自三价铁，五价钒和六价钼的金属的金属氧化物的存在下反应， 非挥发性强酸：其中，R 5各自独立地为氢原子，卤素原子，碳原子数为1〜3的烷基或碳原子数为1〜3的烷氧基。

    Process for producing triphenylene compound and crystal obtained by the process
    9.
    发明授权
    Process for producing triphenylene compound and crystal obtained by the process 有权
    通过该方法得到的三亚苯化合物和晶体的生产方法

    公开(公告)号：US07964757B2

    公开(公告)日：2011-06-21

    申请号：US12670707

    申请日：2008-08-06

    Applicant: Daisuke Takano ,  Tomokazu Kato ,  Toshihiro Fujinaka ,  Kazunori Sakamoto

    Inventor： Daisuke Takano ,  Tomokazu Kato ,  Toshihiro Fujinaka ,  Kazunori Sakamoto

    IPC: C07C39/19 ,  C07C37/00

    CPC classification number: C07C39/12 ,  C07B2200/13 ,  C07C37/11 ,  C07C37/84 ,  C07C2603/42 ,  Y02P20/55

    Abstract: An object of the present invention is to provide a process for producing high-purity hydroxytriphenylenes in which not only inexpensive raw materials can be used but also no complicated steps of deprotection such as dealkylation, and reduction and the like are necessary, and which is thereby advantageous in industrial production. Also there is provided a novel crystal of 2,3,6,7,10,11-hexahydroxytriphenylene monohydrate, which has satisfactory thermal stability. The process for producing a compound represented by the general formula (2) is characterized by reacting a compound represented by the general formula (1) in the presence of a metal oxide comprising a metal selected from trivalent iron, pentavalent vanadium and hexavalent molybdenum and of a nonvolatile strong acid: wherein, Rs are each independently a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms or an alkoxy group having 1 to 3 carbon atoms.

    Abstract translation: 本发明的目的是提供一种生产高纯度羟基三苯并噻吩的方法，其中不仅可以使用便宜的原料，而且还不需要复杂的脱保护步骤如脱烷基化和还原等，从而 有利于工业生产。 还提供了具有令人满意的热稳定性的2,3,6,7,10,11-六羟基三亚苯一水合物的新晶体。 由通式（2）表示的化合物的制备方法的特征在于使通式（1）表示的化合物在包含选自三价铁，五价钒和六价钼的金属的金属氧化物的存在下反应， 非挥发性强酸：其中，R 5各自独立地为氢原子，卤素原子，碳原子数为1〜3的烷基或碳原子数为1〜3的烷氧基。

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