DETERMINING CANCER RESPONSIVENESS TO TREATMENT

    公开(公告)号:US20210364519A1

    公开(公告)日:2021-11-25

    申请号:US17053707

    申请日:2018-12-21

    Abstract: Provided herein are methods of treating a cancer with or predicting the responsiveness of a cancer to an anti-cancer agent which is capable of inhibiting an enzyme that mediates repair of DNA strand breaks, such as PARP, said method including the step of determining an expression level of SASH1. A method of treating a cancer that includes administering a therapeutically effective amount of an agent that increases the expression and/or an activity of SASH1 is also provided. Further provided herein are methods for identifying an agent that modulates the expression and/or an activity of SASH1 for use in the treatment of cancer.

    SURGICAL TRAINING DEVICE
    44.
    发明申请

    公开(公告)号:US20200294422A1

    公开(公告)日:2020-09-17

    申请号:US16765239

    申请日:2018-11-30

    Abstract: Disclosed is a suturing training device and a method of using the device. The device comprises a base having a first side and a second side, the base defining a plane. The device also comprises a first anchor and a second anchor positioned on the first side of the base. The first and second anchors are each connectable to a segment of tissue so that the tissue is suspended therebetween in use of the device. An actuator is associated with one or both of the first anchor and the second anchor. The actuator is actuatable to cause relative movement of the first and second anchors along the plane. A force gauge is configured to measure a force applied to the tissue when the first and second anchors are moved relative one another by the actuator.

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