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    METHODS, DEVICES AND SYSTEMS FOR 3-STAGE FILTRATION
    41.
    发明申请
    METHODS, DEVICES AND SYSTEMS FOR 3-STAGE FILTRATION 有权

    公开(公告)号：US20210284687A1

    公开(公告)日：2021-09-16

    申请号：US17331963

    申请日：2021-05-27

    Applicant: REPLIGEN CORPORATION

    Inventor： Michael Bransby

    IPC: C07K1/36 ,  B01D63/02 ,  B01D69/08

    Abstract: The present disclosure pertains to filtration methods comprising: passing a first fluid that comprises cells, cell debris and targeted product produced by the cells through a first filter thereby separating the first fluid into a first retentate comprising cells and a first permeate comprising targeted product and cell debris; combining resin beads having affinity for targeted product with the first permeate to form a second fluid containing resin beads with bound target product and cell debris; passing the second fluid through a second filter thereby separating the second fluid into a second retentate comprising resin beads with bound target product and a second permeate comprising cell debris; combining an elution buffer with the second retentate to form a third fluid that comprises a mixture of resin beads and unbound targeted product; and passing the third fluid through a third filter thereby separating resin beads from targeted product.

    FC BINDING PROTEINS WITH CYSTEINE IN THE C-TERMINAL HELICAL REGION
    44.
    发明申请
    FC BINDING PROTEINS WITH CYSTEINE IN THE C-TERMINAL HELICAL REGION 有权

    公开(公告)号：US20210054044A1

    公开(公告)日：2021-02-25

    申请号：US16965833

    申请日：2019-01-28

    Applicant: Repligen Corporation

    Inventor： Erik Fiedler ,  Ulrich Haupts

    IPC: C07K14/735 ,  C07K1/14

    Abstract: The present invention relates to Fc binding proteins comprising one or more domains with Cysteine in the C-terminal helical region. The invention further relates to affinity matrices comprising the Fc binding proteins of the invention. The invention also relates to a use of these Fc binding proteins or affinity matrices for affinity purification of immunoglobulins and to methods of affinity purification using the Fc binding proteins of the invention.

    Fluid plug for sterile processes and methods of using the same
    45.
    发明授权
    Fluid plug for sterile processes and methods of using the same 有权

    公开(公告)号：US10914415B2

    公开(公告)日：2021-02-09

    申请号：US15749773

    申请日：2016-08-03

    Applicant: Repligen Corporation

    Inventor： Michael C. Gagne

    IPC: F16L55/11 ,  A61L2/07 ,  A61L2/08 ,  A61L2/20

    Abstract: A fluid plug for use with sterile processes such as the manufacture or production of pharmaceuticals and biologics is disclosed. The fluid plug is made of a material or materials that will tolerate sterilizing processes such as gamma irradiation. The fluid plug is used to selectively plug the ends of flexible polymer conduits that may be connected to fluids, reagents, or products used or generated as part of the manufacturing process. Also disclosed is the use of the plugs in combination with a series of valves in a block-and-bleed arrangement to enable the sterile transfer and connection of fluids, reagents, or products within a process flow.

    METHODS, DEVICES AND SYSTEMS FOR 3-STAGE FILTRATION
    47.
    发明申请
    METHODS, DEVICES AND SYSTEMS FOR 3-STAGE FILTRATION 审中-公开

    公开(公告)号：US20190337979A1

    公开(公告)日：2019-11-07

    申请号：US15972442

    申请日：2018-05-07

    Applicant: REPLIGEN CORPORATION

    Inventor： Michael Bransby

    IPC: C07K1/36 ,  B01D63/02 ,  B01D69/08

    Abstract: The present disclosure pertains to filtration methods comprising: passing a first fluid that comprises cells, cell debris and targeted product produced by the cells through a first filter thereby separating the first fluid into a first retentate comprising cells and a first permeate comprising targeted product and cell debris; combining resin beads having affinity for targeted product with the first permeate to form a second fluid containing resin beads with bound target product and cell debris; passing the second fluid through a second filter thereby separating the second fluid into a second retentate comprising resin beads with bound target product and a second permeate comprising cell debris; combining an elution buffer with the second retentate to form a third fluid that comprises a mixture of resin beads and unbound targeted product; and passing the third fluid through a third filter thereby separating resin beads from targeted product.

    DUAL PUMPING ARRANGEMENT FOR A HOLLOW FIBER FILTER
    50.
    发明申请
    DUAL PUMPING ARRANGEMENT FOR A HOLLOW FIBER FILTER 审中-公开

    公开(公告)号：US20190201819A1

    公开(公告)日：2019-07-04

    申请号：US15856204

    申请日：2017-12-28

    Applicant: REPLIGEN CORPORATION

    Inventor： Rudolf Pavlik

    IPC: B01D29/90 ,  B01D35/26 ,  B01D29/11 ,  B01D37/04 ,  C12M1/00 ,  C12M1/36

    Abstract: A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.

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