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    VESSEL, SYSTEM, AND ASSOCIATED METHOD FOR PRODUCT CONCENTRATION
    3.
    发明公开
    VESSEL, SYSTEM, AND ASSOCIATED METHOD FOR PRODUCT CONCENTRATION 审中-公开

    公开(公告)号：US20230211292A1

    公开(公告)日：2023-07-06

    申请号：US18071899

    申请日：2022-11-30

    Applicant: Repligen Corporation

    Inventor： Steven V. Cates ,  Rudolf Pavlik ,  Bao Le

    IPC: B01D61/18 ,  C12M1/00 ,  B01D61/14 ,  B01F27/85

    CPC classification number: B01D61/18 ,  C12M47/02 ,  B01D61/145 ,  B01F27/851 ,  B01D2315/10 ,  B01D63/02

    Abstract: Vessel configured to facilitate concentration of a product in a solution. The vessel may include outlet ports to deliver the solution to a processing system (such as a filtration system), and inlet ports. The inlet ports may be at progressively lower levels for return of fluid thereto reduced in volume as a result of filtration thereof. A smaller volume sump may be provided below a main tank of the vessel to facilitate concentration of the solution. The sump may include ridges facilitating collection of the product of interest from the solution, and/or reinforcing the sump walls, and optionally forming a vortex breaker. A spray ball may be provided to spray materials, such as buffer solution, into the vessel. The spray ball may direct materials to facilitate retrieval of product from the vessel. One or more components of the vessel may be advantageously formed of disposable material for single use thereof.

    METHOD OF ACTUATION OF AN ALTERNATING TANGENTIAL FLOW DIAPHRAGM PUMP
    4.
    发明申请
    METHOD OF ACTUATION OF AN ALTERNATING TANGENTIAL FLOW DIAPHRAGM PUMP 有权

    公开(公告)号：US20220282204A1

    公开(公告)日：2022-09-08

    申请号：US17752345

    申请日：2022-05-24

    Applicant: Repligen Corporation

    Inventor： Rudolf Pavlik

    IPC: C12M1/36 ,  F04B49/20 ,  C12M1/34 ,  F04B23/04 ,  C12M1/00 ,  F04B43/073 ,  F04B43/00 ,  F04B49/06 ,  B01D61/22 ,  B01D61/58 ,  B01D63/02 ,  B01D61/20

    Abstract: A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.

    HOLLOW FIBER FILTRATION SYSTEMS AND METHODS
    6.
    发明申请
    HOLLOW FIBER FILTRATION SYSTEMS AND METHODS 有权

    公开(公告)号：US20220088538A1

    公开(公告)日：2022-03-24

    申请号：US17417618

    申请日：2020-01-10

    Applicant: Repligen Corporation

    Inventor： Rudolf Pavlik

    IPC: B01D61/20 ,  B01D61/18 ,  B01D63/02 ,  C12M1/26 ,  C12M1/00 ,  F04B45/04 ,  F04B53/16

    Abstract: The present disclosure provides apparatuses and methods that integrate sensors into bioprocessing systems and, advantageously, do not require significant re-engineering of these systems. The disclosure describes an assembly for alternating tangential flow filtration. The assembly also includes a sensor inserted into the first hemisphere of the pump housing via the port. In various embodiments, the port comprises a tri-clover connector, and the sensor is optionally inserted into the port through a plug sized to substantially occlude the port and to place the sensor in contact with a fluid in the pump housing.

    DUAL PUMPING ARRANGEMENT FOR A HOLLOW FIBER FILTER
    7.
    发明申请
    DUAL PUMPING ARRANGEMENT FOR A HOLLOW FIBER FILTER 审中-公开

    公开(公告)号：US20190201819A1

    公开(公告)日：2019-07-04

    申请号：US15856204

    申请日：2017-12-28

    Applicant: REPLIGEN CORPORATION

    Inventor： Rudolf Pavlik

    IPC: B01D29/90 ,  B01D35/26 ,  B01D29/11 ,  B01D37/04 ,  C12M1/00 ,  C12M1/36

    Abstract: A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.

    DEVICES, SYSTEMS, AND METHODS FOR A DIAPHRAGM PUMP
    8.
    发明公开
    DEVICES, SYSTEMS, AND METHODS FOR A DIAPHRAGM PUMP 审中-公开

    公开(公告)号：US20240141891A1

    公开(公告)日：2024-05-02

    申请号：US18270910

    申请日：2022-01-11

    Applicant: Repligen Corporation

    Inventor： Rudolf Pavlik

    IPC: F04B53/20 ,  F04B43/02 ,  F04B45/04

    CPC classification number: F04B53/20 ,  F04B43/02 ,  F04B45/04

    Abstract: The present disclosure relates to diaphragm pumps with one or more filters, e.g., tangential flow filters, membranes, and ultrafiltration membranes, for various applications, including, e.g., bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same. In an aspect, a pump for alternating tangential flow filtration may include a diaphragm. A housing may contain the diaphragm. The housing may have a first end open to a retentate channel of a first membrane. A magnetic member may be coupled to the diaphragm. An electromagnetic field generator may be disposed about the magnetic member.

    Dual pumping arrangement for a hollow fiber filter
    10.
    发明授权
    Dual pumping arrangement for a hollow fiber filter 有权

    公开(公告)号：US11433326B2

    公开(公告)日：2022-09-06

    申请号：US17014465

    申请日：2020-09-08

    Applicant: REPLIGEN CORPORATION

    Inventor： Rudolf Pavlik

    IPC: B01D29/90 ,  B01D35/26 ,  B01D29/11 ,  B01D37/04 ,  B01D63/00 ,  B01D63/02 ,  C12M1/36 ,  C12M1/00

    Abstract: A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.

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