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    Micro alternating tangential flow perfusion filter, micro bioreactor, and methods of use thereof
    4.
    发明授权
    Micro alternating tangential flow perfusion filter, micro bioreactor, and methods of use thereof 有权

    公开(公告)号：US11339364B2

    公开(公告)日：2022-05-24

    申请号：US16171867

    申请日：2018-10-26

    Applicant: Repligen Corporation

    Inventor： Michael Bransby ,  Philip Yuen

    IPC: B01D61/14 ,  B01D61/18 ,  C12M1/00 ,  C12M1/26

    Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.

    SYSTEMS AND METHODS FOR FILTRATION OF CELL CULTURES
    5.
    发明公开
    SYSTEMS AND METHODS FOR FILTRATION OF CELL CULTURES 审中-公开

    公开(公告)号：US20230235263A1

    公开(公告)日：2023-07-27

    申请号：US18098926

    申请日：2023-01-19

    Applicant: Repligen Corporation

    Inventor： Shashi Kudugunti ,  Earl Pineda ,  Michael Bransby

    IPC: C12M1/00 ,  C12M1/26

    CPC classification number: C12M29/10 ,  C12M29/04 ,  C12M33/14 ,  C12M47/04

    Abstract: A method of improving volumetric productivity from a cell culture includes filtering a cell culture through an ultrafilter or a microfilter operating in tangential flow filtration mode or alternating flow filtration mode, and filtering the cell culture concurrently or intermittently through a tangential flow depth filtration system to remove cellular debris and/or to harvest cell product. A system for filtering biological materials includes a primary filtration system, and a secondary filtration system, where the secondary filtration system comprises a tangential flow depth filtration filter.

    MICRO ALTERNATING TANGENTIAL FLOW PERFUSION FILTER, MICRO BIOREACTOR, AND METHODS OF USE THEREOF
    7.
    发明申请
    MICRO ALTERNATING TANGENTIAL FLOW PERFUSION FILTER, MICRO BIOREACTOR, AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：US20190127678A1

    公开(公告)日：2019-05-02

    申请号：US16171867

    申请日：2018-10-26

    Applicant: Repligen Corporation

    Inventor： Michael Bransby ,  Philip Yuen

    IPC: C12M1/00 ,  C12M1/26 ,  B01D61/14 ,  B01D61/18

    Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.

    METHODS, DEVICES AND SYSTEMS FOR 3-STAGE FILTRATION
    9.
    发明申请
    METHODS, DEVICES AND SYSTEMS FOR 3-STAGE FILTRATION 有权

    公开(公告)号：US20210284687A1

    公开(公告)日：2021-09-16

    申请号：US17331963

    申请日：2021-05-27

    Applicant: REPLIGEN CORPORATION

    Inventor： Michael Bransby

    IPC: C07K1/36 ,  B01D63/02 ,  B01D69/08

    Abstract: The present disclosure pertains to filtration methods comprising: passing a first fluid that comprises cells, cell debris and targeted product produced by the cells through a first filter thereby separating the first fluid into a first retentate comprising cells and a first permeate comprising targeted product and cell debris; combining resin beads having affinity for targeted product with the first permeate to form a second fluid containing resin beads with bound target product and cell debris; passing the second fluid through a second filter thereby separating the second fluid into a second retentate comprising resin beads with bound target product and a second permeate comprising cell debris; combining an elution buffer with the second retentate to form a third fluid that comprises a mixture of resin beads and unbound targeted product; and passing the third fluid through a third filter thereby separating resin beads from targeted product.

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