公开(公告)号：US07927835B2

公开(公告)日：2011-04-19

申请号：US12167680

申请日：2008-07-03

Applicant: Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

Inventor： Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

IPC: C07H21/04 ,  C12N15/00 ,  C12N15/11

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4703 ,  C07K14/51 ,  C07K14/52 ,  C07K14/5431 ,  C07K14/705 ,  C07K16/2851 ,  C07K16/2854 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/24 ,  C12N9/10 ,  C12N9/1051 ,  C12N9/6454 ,  C12N2770/36222

Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

Abstract translation: 公开了一种新型P-选择素配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。 还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。 还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。

公开(公告)号：US07926049B1

公开(公告)日：2011-04-12

申请号：US11388174

申请日：2006-03-23

Applicant: Ravindra Kumar

Inventor： Ravindra Kumar

IPC: G06F9/45

CPC classification number: G06F9/44505

Abstract: A system and method for determining differences between configurations of a software program. A configuration differencing command generates a hash table of configuration keys and values for each of the configurations being compared. A key is selected from a first hash table and the command determines if an identical key exists in the second hash table. If the key exists in the second hash table, a comparison is made of the values associated with the keys and, if the values are not identical, the configuration differencing command displays the differences to an administrator.

Abstract translation: 一种用于确定软件程序的配置之间的差异的系统和方法。 配置差异命令为每个正在比较的配置生成配置密钥和值的哈希表。 从第一散列表中选择密钥，并且该命令确定在第二哈希表中是否存在相同的密钥。 如果密钥存在于第二个哈希表中，则对与密钥相关的值进行比较，如果值不相同，则配置差异命令将显示与管理员的差异。

公开(公告)号：US20110046057A1

公开(公告)日：2011-02-24

申请号：US12940740

申请日：2010-11-05

Applicant: Asya Grinberg ,  John Knopf ,  Ravindra Kumar ,  Jasbir Seehra

Inventor： Asya Grinberg ,  John Knopf ,  Ravindra Kumar ,  Jasbir Seehra

IPC: A61K38/19 ,  C07K14/52 ,  A61P21/00

CPC classification number: C07K14/475 ,  A61K38/00 ,  A61K38/179

Abstract: The disclosure relates to Cerberus/Coco polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11.

Abstract translation: 本公开涉及用于治疗与肌生长抑制素，结节和GDF-11相关的多种疾病的Cerberus / Coco多肽或其变体。

公开(公告)号：US20100310577A1

公开(公告)日：2010-12-09

申请号：US12796332

申请日：2010-06-08

Applicant: John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

Inventor： John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

IPC: A61K39/395 ,  A61K38/16 ,  A61K31/7088 ,  A61K38/18 ,  A61P3/00

CPC classification number: C07K16/40 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/1796 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P21/00 ,  C07K14/71 ,  C07K2319/30 ,  C12N5/0602

Abstract: In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Nodal, anti-activin, and anti-GDF11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.

Abstract translation: 在某些方面，本发明提供通过施用ActRIIB信号传导途径的拮抗剂来增加产热脂肪细胞（例如，棕色脂肪细胞或其他表达UCP-1的脂肪细胞）的组合物和方法。 这些拮抗剂的实例包括ActRIIB多肽，抗ActRIIB抗体，抗肌生成抑制素抗体，抗GDF3抗体，抗淋巴结，抗激活素和抗GDF11抗体。 可以通过引起生热脂肪细胞的增加来治疗各种代谢和其它疾病。

公开(公告)号：US07842663B2

公开(公告)日：2010-11-30

申请号：US12012652

申请日：2008-02-04

Applicant: John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

Inventor： John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

IPC: A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71

CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/18 ,  C07K2319/30 ,  C07K2319/70

Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.

Abstract translation: 在某些方面，本发明提供用于调节（促进或抑制）组织如骨，软骨，肌肉，脂肪和/或神经元组织的生长的组合物和方法。 本发明还提供筛选调节ActRIIB蛋白和/或ActRIIB配体的活性的化合物的方法。 本文提供的组合物和方法可用于治疗与ActRIIB蛋白和/或ActRIIB配体的异常活性相关的疾病。

公开(公告)号：US20100166550A1

公开(公告)日：2010-07-01

申请号：US12347329

申请日：2008-12-31

Applicant: Siddaraja M. Devangada ,  Ravindra Kumar

Inventor： Siddaraja M. Devangada ,  Ravindra Kumar

IPC: F01D9/02 ,  B23P15/02

CPC classification number: F01D5/16 ,  F01D5/26 ,  F01D9/041 ,  Y10T29/49336

Abstract: A method of tuning a compressor stator blade, having a base portion and an airfoil portion, to achieve a desired natural frequency, comprising: a) identifying the natural frequency of the compressor stator blade; b) determining a different target natural frequency for the compressor stator blade; and c) removing material from at least one of the side surfaces of the base portion of the compressor stator blade in an amount and in a configuration that achieves the target natural frequency.

Abstract translation: 一种调节压缩机定子叶片的方法，所述压缩机定子叶片具有基部和翼型部分，以实现期望的固有频率，包括：a）识别压缩机定子叶片的固有频率; b）确定压缩机定子叶片的不同目标固有频率; 以及c）以达到目标固有频率的量和配置从所述压缩机定子叶片的基部的至少一个侧表面去除材料。

公开(公告)号：US20090311272A1

公开(公告)日：2009-12-17

申请号：US12434598

申请日：2009-05-01

Applicant: Asya Grinberg ,  John Knopf ,  Ravindra Kumar ,  Robert S. Pearsall ,  Jasbir Seehra ,  Kristian Pietras

Inventor： Asya Grinberg ,  John Knopf ,  Ravindra Kumar ,  Robert S. Pearsall ,  Jasbir Seehra ,  Kristian Pietras

IPC: A61K39/395 ,  C07K16/30 ,  A61P35/00

CPC classification number: C07K16/2896 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/40 ,  C07K2317/76 ,  C07K2319/32

Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.

Abstract translation: 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 此外，本公开表明ALK1的抑制剂可用于增加血管化组织（包括肿瘤和视网膜）中的周细胞覆盖。 本公开还鉴定了ALK1的配体，并证明这些配体具有促血管生成活性，并描述了抑制受体 - 配体相互作用的抗体。

公开(公告)号：US07563760B2

公开(公告)日：2009-07-21

申请号：US09935144

申请日：2001-08-21

Applicant: Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

Inventor： Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

IPC: A61K38/00 ,  A61K39/395

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4703 ,  C07K14/51 ,  C07K14/52 ,  C07K14/5431 ,  C07K14/705 ,  C07K16/2851 ,  C07K16/2854 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/24 ,  C12N9/10 ,  C12N9/1051 ,  C12N9/6454 ,  C12N2770/36222

Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

Abstract translation: 公开了一种新型P-选择素配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。 还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。 还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。

公开(公告)号：US20090104180A1

公开(公告)日：2009-04-23

申请号：US12167663

申请日：2008-07-03

Applicant: Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

Inventor： Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

IPC: A61K39/395 ,  A01N1/02 ,  A61K38/16 ,  A61K38/43 ,  A61K38/10

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4703 ,  C07K14/51 ,  C07K14/52 ,  C07K14/5431 ,  C07K14/705 ,  C07K16/2851 ,  C07K16/2854 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/24 ,  C12N9/10 ,  C12N9/1051 ,  C12N9/6454 ,  C12N2770/36222

Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

Abstract translation: 公开了一种新型P-选择素配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。 还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。 还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。

公开(公告)号：US20090028883A1

公开(公告)日：2009-01-29

申请号：US12167705

申请日：2008-07-03

Applicant: Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

Inventor： Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

IPC: A61K39/395 ,  C07K14/47 ,  A61K38/17 ,  A61P29/00 ,  C07K16/18

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4703 ,  C07K14/51 ,  C07K14/52 ,  C07K14/5431 ,  C07K14/705 ,  C07K16/2851 ,  C07K16/2854 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/24 ,  C12N9/10 ,  C12N9/1051 ,  C12N9/6454 ,  C12N2770/36222

Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

Abstract translation: 公开了一种新型P-选择素配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。 还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。 还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。