-
公开(公告)号：US20080175844A1
公开(公告)日：2008-07-24
申请号：US11982738
申请日：2007-11-02
CPC分类号： A61K39/39558 , A61K45/06 , C07K14/71 , C07K16/18 , C07K2317/52 , C07K2319/30
摘要： In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and antibodies that inhibit receptor-ligand interaction.
摘要翻译： 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 该公开内容还鉴定了ALK1的配体，并证明这些配体具有促血管生成活性，以及抑制受体 - 配体相互作用的抗体。
-
2.发明授权Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof 有权BMP9，BMP10，ALK1和其他ALK1配体的拮抗剂及其用途公开(公告)号：US08642031B2
公开(公告)日：2014-02-04
申请号：US12467170
申请日：2009-05-15
申请人： Jasbir Seehra , John Knopf , Robert S. Pearsall , Asya Grinberg , Ravindra Kumar
发明人： Jasbir Seehra , John Knopf , Robert S. Pearsall , Asya Grinberg , Ravindra Kumar
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K9/0048 , A61K38/1709 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/71 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. In certain aspects, the disclosure demonstrates that antagonists of BMP9 and/or BMP10, ligands for ALK1, may also be used to inhibit angiogenesis in vivo.
摘要翻译： 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 在某些方面，本公开表明BMP9和/或BMP10的拮抗剂，ALK1的配体也可用于抑制体内血管发生。
-
公开(公告)号：US20110046057A1
公开(公告)日：2011-02-24
申请号：US12940740
申请日：2010-11-05
申请人： Asya Grinberg , John Knopf , Ravindra Kumar , Jasbir Seehra
发明人： Asya Grinberg , John Knopf , Ravindra Kumar , Jasbir Seehra
CPC分类号： C07K14/475 , A61K38/00 , A61K38/179
摘要： The disclosure relates to Cerberus/Coco polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11.
摘要翻译： 本公开涉及用于治疗与肌生长抑制素，结节和GDF-11相关的多种疾病的Cerberus / Coco多肽或其变体。
-
4.发明申请公开(公告)号：US20090311272A1
公开(公告)日：2009-12-17
申请号：US12434598
申请日：2009-05-01
申请人： Asya Grinberg , John Knopf , Ravindra Kumar , Robert S. Pearsall , Jasbir Seehra , Kristian Pietras
发明人： Asya Grinberg , John Knopf , Ravindra Kumar , Robert S. Pearsall , Jasbir Seehra , Kristian Pietras
IPC分类号： A61K39/395 , C07K16/30 , A61P35/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K14/71 , C07K16/40 , C07K2317/76 , C07K2319/32
摘要： In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
摘要翻译： 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 此外，本公开表明ALK1的抑制剂可用于增加血管化组织（包括肿瘤和视网膜）中的周细胞覆盖。 本公开还鉴定了ALK1的配体，并证明这些配体具有促血管生成活性，并描述了抑制受体 - 配体相互作用的抗体。
-
公开(公告)号：US08796199B2
公开(公告)日：2014-08-05
申请号：US12940740
申请日：2010-11-05
申请人： Asya Grinberg , John Knopf , Ravindra Kumar , Jasbir Seehra
发明人： Asya Grinberg , John Knopf , Ravindra Kumar , Jasbir Seehra
IPC分类号： C07K14/00
CPC分类号： C07K14/475 , A61K38/00 , A61K38/179
摘要： The disclosure relates to Cerberus/Coco polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11.
摘要翻译： 本公开涉及用于治疗与肌生长抑制素，结节和GDF-11相关的多种疾病的Cerberus / Coco多肽或其变体。
-
公开(公告)号：US08158584B2
公开(公告)日：2012-04-17
申请号：US12434598
申请日：2009-05-01
申请人： Asya Grinberg , John Knopf , Ravindra Kumar , Robert S. Pearsall , Jasbir Seehra , Kristian Pietras
发明人： Asya Grinberg , John Knopf , Ravindra Kumar , Robert S. Pearsall , Jasbir Seehra , Kristian Pietras
CPC分类号： C07K16/2896 , A61K2039/505 , C07K14/71 , C07K16/40 , C07K2317/76 , C07K2319/32
摘要： In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
摘要翻译： 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 此外，本公开表明ALK1的抑制剂可用于增加血管化组织（包括肿瘤和视网膜）中的周细胞覆盖。 本公开还鉴定了ALK1的配体，并证明这些配体具有促血管生成活性，并且描述了抑制受体 - 配体相互作用的抗体。
-
公开(公告)号：US07833971B2
公开(公告)日：2010-11-16
申请号：US12001494
申请日：2007-12-10
申请人： Asya Grinberg , John Knopf , Ravindra Kumar , Jasbir Seehra
发明人： Asya Grinberg , John Knopf , Ravindra Kumar , Jasbir Seehra
IPC分类号： C07K14/00
CPC分类号： C07K14/475 , A61K38/00 , A61K38/179
摘要： The disclosure relates to Cerberus/Coco polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11.
摘要翻译： 本公开涉及用于治疗与肌生成抑制素，结节和GDF-11相关的多种疾病的Cerberus / Coco多肽或其变体。
-
8.发明申请ANTAGONISTS OF BMP9, BMP10, ALK1 AND OTHER ALK1 LIGANDS, AND USES THEREOF 有权BMP9，BMP10，ALK1和其他ALK1配体的拮抗剂及其用途公开(公告)号：US20090304691A1
公开(公告)日：2009-12-10
申请号：US12467170
申请日：2009-05-15
申请人： Jasbir Seehra , John Knopf , Robert S. Pearsall , Asya Grinberg , Ravindra Kumar
发明人： Jasbir Seehra , John Knopf , Robert S. Pearsall , Asya Grinberg , Ravindra Kumar
IPC分类号： A61K39/395 , C07K16/18 , A61K31/7088 , A61K31/7105 , A61K38/16 , A61P35/00
CPC分类号： C07K16/22 , A61K9/0048 , A61K38/1709 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/71 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. In certain aspects, the disclosure demonstrates that antagonists of BMP9 and/or BMP10, ligands for ALK1, may also be used to inhibit angiogenesis in vivo.
摘要翻译： 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 在某些方面，本公开表明BMP9和/或BMP10的拮抗剂，ALK1的配体也可用于抑制体内血管发生。
-
公开(公告)号：US10059756B2
公开(公告)日：2018-08-28
申请号：US13447091
申请日：2012-04-13
申请人： Asya Grinberg , John Knopf , Robert S. Pearsall , Ravindra Kumar , Jasbir Seehra , Kristian Pietras
发明人： Asya Grinberg , John Knopf , Robert S. Pearsall , Ravindra Kumar , Jasbir Seehra , Kristian Pietras
CPC分类号： C07K14/71 , C07K2319/30 , C07K2319/32
摘要： In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
-
公开(公告)号：US08455428B2
公开(公告)日：2013-06-04
申请号：US11982738
申请日：2007-11-02
申请人： Asya Grinberg , John Knopf , Robert S. Pearsall , Ravindra Kumar , Jasbir Seehra
发明人： Asya Grinberg , John Knopf , Robert S. Pearsall , Ravindra Kumar , Jasbir Seehra
IPC分类号： A61K38/00
CPC分类号： A61K39/39558 , A61K45/06 , C07K14/71 , C07K16/18 , C07K2317/52 , C07K2319/30
摘要： In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and antibodies that inhibit receptor-ligand interaction.
摘要翻译： 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 该公开内容还鉴定了ALK1的配体，并证明这些配体具有促血管生成活性，以及抑制受体 - 配体相互作用的抗体。
-
-
-
-
-
-
-
-
-
搜索结果
90 条记录 (耗时 0.033 秒)
