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    ANTI-SORTILIN ANTIBODIES AND METHODS OF USE THEREOF
    42.
    发明申请
    ANTI-SORTILIN ANTIBODIES AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：US20190085084A1

    公开(公告)日：2019-03-21

    申请号：US16134830

    申请日：2018-09-18

    Applicant: Alector LLC

    Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas

    IPC: C07K16/28 ,  A61K31/7088

    Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

    ANTI-SORTILIN ANTIBODIES AND METHODS OF USE THEREOF
    43.
    发明申请
    ANTI-SORTILIN ANTIBODIES AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：US20190062433A1

    公开(公告)日：2019-02-28

    申请号：US16058817

    申请日：2018-08-08

    Applicant: ALECTOR LLC

    Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas

    IPC: C07K16/28 ,  A61K31/7088

    Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

    Anti-sortilin antibodies and methods of use thereof
    44.
    发明授权
    Anti-sortilin antibodies and methods of use thereof 有权

    公开(公告)号：US10087255B2

    公开(公告)日：2018-10-02

    申请号：US15285359

    申请日：2016-10-04

    Applicant: ALECTOR LLC

    Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas

    IPC: A61K39/395 ,  C07K16/28

    Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

    ANTI-APOE4 ANTIGEN-BINDING PROTEINS AND METHODS OF USE THEREOF
    45.
    发明申请
    ANTI-APOE4 ANTIGEN-BINDING PROTEINS AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：US20170218058A1

    公开(公告)日：2017-08-03

    申请号：US15414955

    申请日：2017-01-25

    Applicant: Alector, LLC

    Inventor： Arnon Rosenthal

    IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06

    CPC classification number: C07K16/18 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/30 ,  C07K2317/622

    Abstract: The present disclosure generally relates to antigen-binding proteins (ABPs) that specifically bind to apolipoprotein E (ApoE), compositions comprising such ABPs, methods of using such ABPs, and methods of making such ABPs. In some embodiments, the ABPs provided herein bind lipidated ApoE4. In some embodiments, the lipidated ApoE4 is within a lipoprotein particle, and the ABPs therefore bind to a lipoprotein particle comprising ApoE4. Any suitable ABP may be used. In some embodiments, the ABP is an antibody. In some embodiments, the ABP is an alternative scaffold. The ABPs provided herein may be used for the prevention or treatment of any disease, condition or disorder associated with ApoE4 expression.

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