-
公开(公告)号：US20130156770A1
公开(公告)日：2013-06-20
申请号：US13678264
申请日：2012-11-15
发明人： Peter Kufer , Tobias Raum , Patrick Hoffmann , Roman Kischel , Ralf Lutterbuese , Doris Rau , Paul Adam , Eric Borges , Barbara Hebeis , Susanne Hipp
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , A61K39/0005 , A61K2039/505 , A61K2039/575 , C07K14/70578 , C07K16/2809 , C07K16/2875 , C07K16/2878 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/43
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
摘要翻译： 本发明涉及包含第一和第二结合结构域的结合分子，其中第一结合结构域能够结合BCMA的表位簇，并且第二结合结构域能够结合T细胞CD3受体复合物。 此外，本发明提供编码结合分子的核酸序列，包含所述核酸序列的载体和用所述载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的结合分子的方法，所述结合分子的医学用途和包含所述结合分子的试剂盒。
-
公开(公告)号：US11884720B2
公开(公告)日：2024-01-30
申请号：US15225423
申请日：2016-08-01
发明人： Tobias Raum , Jonas Anlahr , Julie Bailis , Claudia Blümel , Patrick Hoffmann , Peter Kufer , Elisabeth Nahrwold , Doris Rau
CPC分类号： C07K16/28 , C07K16/2809 , C07K16/30 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human MSLN on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
-
公开(公告)号：US11661462B2
公开(公告)日：2023-05-30
申请号：US15329672
申请日：2015-07-31
发明人： Benno Rattel , Matthias Friedrich , Peter Kufer , Patrick Hoffmann , Tobias Raum , Markus Münz , Ines Herrmann , Ralf Lutterbüse , Elisabeth Nahrwold
IPC分类号： C07K16/46 , C07K16/28 , C07K14/765 , A61K39/00
CPC分类号： C07K16/468 , C07K14/765 , C07K16/2803 , C07K16/2809 , A61K2039/505 , C07K2317/14 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/94 , C07K2319/31
摘要： The present invention provides to a bispecific single chain antibody construct binding to a target cell surface antigen via a first binding domain and to the T cell surface antigen CD3 via a second binding domain, wherein serum albumin is fused to the C-terminus of the antibody construct. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
-
公开(公告)号：US20230057728A1
公开(公告)日：2023-02-23
申请号：US17693001
申请日：2022-03-11
发明人： Peter Kufer , Tobias Raum , Ralf Lutterbüse , Markus Muenz , Johannes Brozy , Majk Kvesic , Patrick Hoffmann
摘要： The present invention relates to a binding molecule comprising at least three domains comprised in at least one polypeptide chain, wherein the first binding domain is a binding domain which is capable of binding to a cell surface molecule on a target cell, the second binding domain is a binding domain which is capable of binding to the T cell CD3 receptor complex, and the third domain is a binding domain which is capable of binding to serum albumin, wherein said third domain is positioned at the C-terminus of said second domain. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
-
公开(公告)号：US20220251243A1
公开(公告)日：2022-08-11
申请号：US17672546
申请日：2022-02-15
发明人： Peter Kufer , Tobias Raum , Patrick Hoffmann , Roman Kischel , Ralf Lutterbuese , Doris Rau , Paul Adam , Eric Borges , Barbara Hebeis , Susanne Hipp
IPC分类号： C07K16/46 , C07K16/28 , C07K14/705 , A61K39/00
摘要： The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
-
公开(公告)号：US20220064308A1
公开(公告)日：2022-03-03
申请号：US17479156
申请日：2021-09-20
发明人： Tobias Raum , Ines Herrmann , Patrick Hoffmann , Peter Kufer , Markus Muenz , Doris Rau
IPC分类号： C07K16/28 , A61K39/395
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human EGFRVIII on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
-
47.发明授权公开(公告)号：US11155629B2
公开(公告)日：2021-10-26
申请号：US16676170
申请日：2019-11-06
发明人： Tobias Raum , Ines Herrmann , Patrick Hoffmann , Peter Kufer , Markus Muenz , Doris Rau
IPC分类号： A61K39/395 , C07K16/28
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human EGFRVIII on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
-
公开(公告)号：US20200332002A1
公开(公告)日：2020-10-22
申请号：US16868257
申请日：2020-05-06
发明人： Tobias Raum , Claudia Blümel , Christoph Dahlhoff , Patrick Hoffmann , Peter Kufer , Ralf Lutterbüse , Elisabeth Nahrwold , Jochen Pendzialek
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
-
公开(公告)号：US10781264B2
公开(公告)日：2020-09-22
申请号：US15422661
申请日：2017-02-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
-
公开(公告)号：US10766969B2
公开(公告)日：2020-09-08
申请号：US14358511
申请日：2012-11-15
发明人： Peter Kufer , Tobias Raum , Patrick Hoffmann , Roman Kischel , Ralf Lutterbuese , Doris Rau , Paul Adam , Eric Borges , Barbara Hebeis , Susanne Hipp
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , C07K14/705 , A61K39/00
摘要： The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster3 of BCMA, and the second binding domain is capable of binding to the Tcell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
-
-
-
-
-
-
-
-
-
搜索结果
79 条记录 (耗时 0.031 秒)
