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公开(公告)号：US20220403035A1
公开(公告)日：2022-12-22
申请号：US17774232
申请日：2020-11-06
发明人： Jonas Anlahr , Tara Arvedson , Julie Bailis , Matthew Chun , Igor D'Angelo , Christopher Dahlhoff , Stephanie Everts , Mattias Friedrich , Lars Gaedtke , Patrick Hoffmann , Rebecca Goldstein , Jonas Karl-Josef Honer , Roman Kischel , Matthias Klinger , Peter Kufer , Markus Muenz
IPC分类号： C07K16/28
摘要： The present invention provides bispecific antigen-binding molecules characterized by comprising a first and a second domain, each binding to any of CS1, BCMA, CD20, CD22, FLT3, CD123, CLL1, MSLN, CDH3 or EpCAM, a third domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and optionally a fourth domain, which is a Fc modality. Moreover, the invention provides a polynucleotide, encoding the antigen-binding molecule, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US11884720B2
公开(公告)日：2024-01-30
申请号：US15225423
申请日：2016-08-01
发明人： Tobias Raum , Jonas Anlahr , Julie Bailis , Claudia Blümel , Patrick Hoffmann , Peter Kufer , Elisabeth Nahrwold , Doris Rau
CPC分类号： C07K16/28 , C07K16/2809 , C07K16/30 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human MSLN on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20240209078A1
公开(公告)日：2024-06-27
申请号：US18251196
申请日：2021-11-08
发明人： Stephanie Everts , Matthias Klinger , Virginie Naegele , Adam Zalewski , Claudia Blümel , Thomas Boehm , Johannes Brozy , Igor D'Angelo , Peter Kufer , Petra Lutterbüse , Markus Muenz , Doris Rau , Tobias Raum , Benno Rattel , Oliver Thomas , Ines Ullrich , Joachim Wahl , Christian Webhofer , Sascha Weidler , Elizabeth Dang Pham , Julie Bailis
CPC分类号： C07K16/28 , A61P35/00 , A61K2039/505 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/92
摘要： The present invention provides multitargeting bispecific antigen-binding molecules characterized by comprising a first and a second bispecific entity each comprising a domain binding to target, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain, wherein both bispecific entities are linked to each other by a spacer which spaces apart the first and the second bispecific entity. Moreover, the invention provides a polynucleotide, encoding the multitargeting bispecific antigen-binding molecule, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US20240174745A1
公开(公告)日：2024-05-30
申请号：US18316739
申请日：2023-05-12
发明人： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
CPC分类号： C07K16/28 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20210130465A1
公开(公告)日：2021-05-06
申请号：US16956797
申请日：2018-12-31
发明人： Tobias Raum , Tara Arvedson , Julie Bailis , Christoph Dahlhoff , Sandra Ross , Irwin Chen , Claudia Blümel , Elisabeth Nahrwold , Jochen Pendzialek , Joachim Wahl
摘要： The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US11692031B2
公开(公告)日：2023-07-04
申请号：US16530006
申请日：2019-08-02
发明人： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
CPC分类号： C07K16/28 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20200055932A1
公开(公告)日：2020-02-20
申请号：US16530006
申请日：2019-08-02
发明人： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
摘要： The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20170029502A1
公开(公告)日：2017-02-02
申请号：US15225423
申请日：2016-08-01
发明人： Tobias Raum , Jonas Anlahr , Julie Bailis , Claudia Blümel , Patrick Hoffmann , Peter Kufer , Elisabeth Nahrwold , Doris Rau
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , C07K16/2809 , C07K16/30 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human MSLN on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
摘要翻译： 本发明涉及双特异性抗体构建体，其包含与靶细胞表面上的人MSLN结合的第一结合结构域和与T细胞表面上的人CD3结合的第二结合结构域。 此外，本发明提供编码抗体构建体的多核苷酸，包含所述多核苷酸的载体和用所述多核苷酸或载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的抗体构建体的方法，所述抗体构建体的医学用途和包含所述抗体构建体的试剂盒。
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公开(公告)号：US20230129844A1
公开(公告)日：2023-04-27
申请号：US17912171
申请日：2021-03-19
申请人： AMGEN INC.
发明人： Kurt Edelmann , Julie Bailis
IPC分类号： G01N33/574 , G01N33/531
摘要： The present invention relates to antibodies that bind to human and monkey mucin 17 (MUC17). Moreover, the invention relates to a detection system comprising such antibodies. The antibodies or the detection system may be used for detecting or quantifying MUC17, for diagnosing a disease associated with MUC17, for patient stratification, monitoring disease progression, and evaluating the therapeutic response.
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