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公开(公告)号：US20200332002A1
公开(公告)日：2020-10-22
申请号：US16868257
申请日：2020-05-06
发明人： Tobias Raum , Claudia Blümel , Christoph Dahlhoff , Patrick Hoffmann , Peter Kufer , Ralf Lutterbüse , Elisabeth Nahrwold , Jochen Pendzialek
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US10683351B2
公开(公告)日：2020-06-16
申请号：US16291826
申请日：2019-03-04
发明人： Tobias Raum , Claudia Blümel , Christoph Dahlhoff , Patrick Hoffmann , Peter Kufer , Ralf Lutterbüse , Elisabeth Nahrwold , Jochen Pendzialek
IPC分类号： A61K39/395 , C07K16/18 , C07K16/22 , C07K16/28 , C07K16/30 , C12N5/07 , C12N15/63 , A61K39/00 , C07K14/475 , C07K14/725
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising the polynucleotide and a host cell transformed or transfected with the polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of the antibody construct and a kit comprising the antibody construct.
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公开(公告)号：US20170037149A1
公开(公告)日：2017-02-09
申请号：US15225568
申请日：2016-08-01
发明人： Tobias Raum , Claudia Blümel , Franziska Bott , Christoph Dahlhoff , Patrick Hoffmann , Elisabeth Nahrwold , Jochen Pendzialek
CPC分类号： C07K16/40 , C07K16/2809 , C07K16/2863 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human FLT3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
摘要翻译： 本发明涉及双特异性抗体构建体，其包含与靶细胞表面上的人FLT3结合的第一结合结构域和与T细胞表面上的人CD3结合的第二结合结构域。 此外，本发明提供编码抗体构建体的多核苷酸，包含所述多核苷酸的载体和用所述多核苷酸或载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的抗体构建体的方法，所述抗体构建体的医学用途和包含所述抗体构建体的试剂盒。
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公开(公告)号：US11591396B2
公开(公告)日：2023-02-28
申请号：US16868257
申请日：2020-05-06
发明人： Tobias Raum , Claudia Blümel , Christoph Dahlhoff , Patrick Hoffmann , Peter Kufer , Ralf Lutterbüse , Elisabeth Nahrwold , Jochen Pendzialek
IPC分类号： A61K39/395 , C07K16/18 , C07K16/22 , C07K16/28 , C07K16/30 , A61K39/00 , C12N15/63 , C12N5/07 , C07K14/475 , C07K14/725
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising the polynucleotide and a host cell transformed or transfected with the polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of the antibody construct and a kit comprising the antibody construct.
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公开(公告)号：US10294300B2
公开(公告)日：2019-05-21
申请号：US15225107
申请日：2016-08-01
发明人： Tobias Raum , Claudia Blümel , Christoph Dahlhoff , Patrick Hoffmann , Peter Kufer , Ralf Lutterbüse , Elisabeth Nahrwold , Jochen Pendzialek
IPC分类号： A61K39/395 , C07K16/18 , C07K16/22 , C07K16/28 , C07K16/30 , A61K39/00 , C07K14/475 , C07K14/725
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20180142021A1
公开(公告)日：2018-05-24
申请号：US15566444
申请日：2016-04-18
发明人： Bertram Weiss , Ann-Lena Frisk , Ruprecht Zierz , Peter Kufer , Tobias Raum , Doris Rau , Jonas Anlahr , Ralf Lutterbüse , Lisa Nahrwold , Christoph Dahlhoff , Claudia Blümel , Patrick Hoffmann
CPC分类号： C07K16/2809 , A61K2039/505 , A61P35/00 , C07K16/28 , C07K16/3053 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20240174745A1
公开(公告)日：2024-05-30
申请号：US18316739
申请日：2023-05-12
发明人： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
CPC分类号： C07K16/28 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US11926666B2
公开(公告)日：2024-03-12
申请号：US17306051
申请日：2021-05-03
发明人： Bertram Weiss , Anna-Lena Frisk , Ruprecht Zierz , Peter Kufer , Tobias Raum , Doris Rau , Jonas Anlahr , Ralf Lutterbüse , Lisa Nahrwold , Christoph Dahlhoff , Claudia Blümel , Patrick Hoffmann
CPC分类号： C07K16/2809 , A61P35/00 , C07K16/28 , C07K16/3053 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20230272113A1
公开(公告)日：2023-08-31
申请号：US17813434
申请日：2022-07-19
发明人： Tobias Raum , Claudia Blümel , Franziska Bott , Christoph Dahlhoff , Patrick Hoffmann , Elisabeth Nahrwold , Jochen Pendzialek
CPC分类号： C07K16/40 , C07K16/2809 , C07K16/2863 , C07K2317/31 , C07K2317/64 , C07K2317/33 , C07K2319/31 , C07K2317/76 , C07K2317/94 , C07K2317/73 , C07K2317/92 , C07K2317/622 , C07K2317/56
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human FLT3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20210130465A1
公开(公告)日：2021-05-06
申请号：US16956797
申请日：2018-12-31
发明人： Tobias Raum , Tara Arvedson , Julie Bailis , Christoph Dahlhoff , Sandra Ross , Irwin Chen , Claudia Blümel , Elisabeth Nahrwold , Jochen Pendzialek , Joachim Wahl
摘要： The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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