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41.发明授权公开(公告)号：US09227963B2
公开(公告)日：2016-01-05
申请号：US14543817
申请日：2014-11-17
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew J. Souers
IPC: A61K31/535 , C07D417/14 , C07D401/04 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
CPC classification number: A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US20150284328A1
公开(公告)日：2015-10-08
申请号：US14683839
申请日：2015-04-10
Applicant: AbbVie Inc.
Inventor： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron R. Kunzer
IPC: C07D209/42 , C07D405/06 , C07D491/113 , C07D401/04
CPC classification number: C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
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43.发明授权BCL-2 selective apoptosis-inducing agents for the treatment of cancer and immune diseases 有权BCL-2选择性细胞凋亡诱导剂用于治疗癌症和免疫疾病公开(公告)号：US09073855B2
公开(公告)日：2015-07-07
申请号：US13839060
申请日：2013-03-15
Applicant: AbbVie Inc.
Inventor： George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Robert A. Mantei , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC: C07D401/10 , C07D213/62 , C07D307/02 , C07D215/14 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/12 , C07D417/12 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D295/13 , C07D309/08 , C07D487/04 , C07D209/20 , C07D295/155 , C07D309/32
CPC classification number: C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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44.发明申请公开(公告)号：US20140113910A1
公开(公告)日：2014-04-24
申请号：US14038409
申请日：2013-09-26
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
IPC: C07D471/04 , A61K31/496
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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45.发明申请公开(公告)号：US20140057890A1
公开(公告)日：2014-02-27
申请号：US14058164
申请日：2013-10-18
Applicant: AbbVie Inc.
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC: A61K31/5377 , A61K31/496 , C07D413/06 , C07D401/06 , A61K45/06 , A61K31/407 , C07D403/06 , A61K31/501 , C07D241/04 , A61K31/495 , C07D405/06 , C07D487/04
CPC classification number: C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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Patent Agency Ranking
![1,3,4,7-TETRAHYDRO-2H-PYRROLO[3',2':5,6]PYRIDO[2,3-B][1,4]OXAZEPINE BCL-2 INHIBITORS](/abs-image/US/2025/02/27/US20250066388A1/abs.jpg.150x150.jpg)
公开(公告)号：US20250066388A1
公开(公告)日：2025-02-27
申请号：US18595898
申请日：2024-03-05
Applicant: AbbVie Inc.
Inventor： George A. Doherty , Vikram Bhat , Andrew S. Judd , Andrew J. Souers , Patrick Brady , Yujia Dai , Jianchun Gong , Yiyun Yu
IPC: C07D519/00
Abstract: The present invention provides for compounds of Formula (I) wherein A, L, W, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL, SLL, and/or ALL.
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47.发明公开公开(公告)号：US20240043404A1
公开(公告)日：2024-02-08
申请号：US18462355
申请日：2023-09-06
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12 , C07D401/14 , C07D519/00 , C07D471/04 , C07D209/82 , C07D403/12 , A61K31/496
CPC classification number: C07D401/12 , C07D401/14 , C07D519/00 , C07D471/04 , C07D209/82 , C07D403/12 , A61K31/496 , Y02A50/30
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US11759527B2
公开(公告)日：2023-09-19
申请号：US17580134
申请日：2022-01-20
Applicant: AbbVie Inc.
Inventor： Erwin R. Boghaert , Andrew C. Phillips , Andrew J. Souers , Kamel Izeradjene , John E. Harlan
CPC classification number: A61K47/6849 , A61K47/6803 , A61P35/00 , C07K16/2863 , A61K2039/505 , C07K2317/73 , C07K2317/92
Abstract: The present disclosure relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods using such ADCs, and methods for making such ADCs.
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公开(公告)号：US20230135723A1
公开(公告)日：2023-05-04
申请号：US17806037
申请日：2022-06-08
Applicant: AbbVie Inc.
Inventor： Lorenzo Benatuil , Milan Bruncko , Andrew S. Judd , Yingchun Li , Andrew Mccluskey , Andrew C. Phillips , Darren C. Phillips , Jane Seagal , Andrew J. Souers
IPC: A61K47/68 , A61P35/00 , A61K31/428 , A61K39/395 , C07K16/28
Abstract: The invention relates to anti-CD98 antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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公开(公告)号：US20230120736A1
公开(公告)日：2023-04-20
申请号：US17731226
申请日：2022-04-27
Applicant: AbbVie Inc.
Inventor： Lorenzo Benatuil , Milan Bruncko , Andrew S. Judd , Yingchun Li , Andrew Mccluskey , Andrew C. Phillips , Darren C. Phillips , Jane Seagal , Andrew J. Souers
IPC: A61K47/68 , A61K31/337 , C07K16/28
Abstract: The invention relates to anti-CD98 antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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