公开(公告)号：US08497463B2

公开(公告)日：2013-07-30

申请号：US13562439

申请日：2012-07-31

Applicant: Bernd Widzgowski

Inventor： Bernd Widzgowski

IPC: G01J1/00 ,  G01T1/15 ,  G01T1/17

CPC classification number: G01J1/44

Abstract: A device for counting photons includes a detector unit that is configured to generate an detected signal. A switching unit is configured to be impinged upon by the detected signal and to trigger a switching state for each detection pulse so as to generate a state signal. A sampling unit is configured to sample the state signal at a predetermined sampling frequency. A serial-parallel converter unit is configured to parallelize the serially generated sampled data by grouping successive sampled data into a sampled data packet. An evaluation unit is configured to evaluate the binary values of sampled data packets so as to identify a partial counter result indicating the number of switching state changes occurring in the switching unit, and to add partial counter results identified in individual clock cycles.

Abstract translation: 用于计数光子的装置包括被配置为产生检测信号的检测器单元。 开关单元被配置为通过检测到的信号入射并触发每个检测脉冲的开关状态，以便产生状态信号。 采样单元被配置为以预定采样频率对状态信号进行采样。 串行并行转换器单元被配置为通过将连续的采样数据分组成采样的数据分组来并行化串行产生的采样数据。 评估单元被配置为评估采样数据分组的二进制值，以便识别指示在切换单元中发生的切换状态改变的数量的部分计数器结果，并且添加在各个时钟周期中标识的部分计数器结果。

公开(公告)号：US07676071B2

公开(公告)日：2010-03-09

申请号：US11367522

申请日：2006-03-03

Applicant: Bernd Widzgowski

Inventor： Bernd Widzgowski

IPC: G06K9/00

CPC classification number: G02B21/365 ,  G02B21/008

Abstract: A method for illuminating a specimen or a region of the specimen (region of interest, ROI), the information indicating whether and in what manner a specific point on the specimen is to be illuminated, being stored in a data memory under a specific address. A change in the position, orientation, and/or shape of the specimen is captured, and a transformation of the coordinates of the image points to be illuminated is derived therefrom; memory addresses are uniquely assigned to the transformed coordinates; and, on the basis of the memory addresses, the data memory is accessed, and its contents is read out in order to control the light source.

Abstract translation: 用于照射样本或感兴趣区域的区域（ROI）的方法，指示样本上的特定点是否以什么样的方式被照亮的信息被存储在特定地址的数据存储器中。 捕获样本的位置，取向和/或形状的变化，并从其中导出要照亮的图像点的坐标的变换; 存储器地址被唯一地分配给变换的坐标; 并且基于存储器地址访问数据存储器，并且读出其内容以便控制光源。

公开(公告)号：US20060232843A1

公开(公告)日：2006-10-19

申请号：US11367522

申请日：2006-03-03

Applicant: Bernd Widzgowski

Inventor： Bernd Widzgowski

IPC: G02B26/08

CPC classification number: G02B21/365 ,  G02B21/008

Abstract: A method for illuminating a specimen or a region of the specimen (region of interest, ROI), the information indicating whether and in what manner a specific point on the specimen is to be illuminated, being stored in a data memory under a specific address. A change in the position, orientation, and/or shape of the specimen is captured, and a transformation of the coordinates of the image points to be illuminated is derived therefrom; memory addresses are uniquely assigned to the transformed coordinates; and, on the basis of the memory addresses, the data memory is accessed, and its contents is read out in order to control the light source.

Abstract translation: 用于照射样本或感兴趣区域的区域（ROI）的方法，指示样本上的特定点是否以什么样的方式被照亮的信息被存储在特定地址的数据存储器中。 捕获样本的位置，取向和/或形状的变化，并从其中导出要照亮的图像点的坐标的变换; 存储器地址被唯一地分配给变换的坐标; 并且基于存储器地址访问数据存储器，并且读出其内容以便控制光源。

公开(公告)号：US06894271B2

公开(公告)日：2005-05-17

申请号：US10287069

申请日：2002-11-04

Applicant: Bernd Widzgowski

Inventor： Bernd Widzgowski

IPC: G02B21/00 ,  H01J3/14 ,  H01J5/16 ,  H01J40/14

CPC classification number: G02B21/0048 ,  G02B21/0036 ,  G02B21/0056

Abstract: A method for operating a positioning apparatus that moves a positioning element comprises the steps of: generating a first and at least one further reference signal, the first reference signal corresponding to a first reference position and the further reference signal to a further reference position; generating a first and at least one further estimated value for the present position of the positioning drive; transferring the first reference signal and the estimated value to the positioning apparatus; establishing the first reference position using the positioning apparatus, and measuring the present position and generating a position signal that corresponds to the measured present position; transferring the further reference signal to the positioning apparatus; generating a further estimated value of the positioning drive position; transferring the further estimated value to the positioning apparatus; establishing the further reference position, and measuring a further present position and generating a further position signal that corresponds to the measured further present position; and cyclically repeating the steps at constant time intervals.

Abstract translation: 一种用于操作移动定位元件的定位装置的方法包括以下步骤：产生第一和至少一个另外的参考信号，所述第一参考信号对应于第一参考位置，所述另外的参考信号产生到另一参考位置; 为所述定位驱动器的当前位置产生第一和至少一个另外的估计值; 将所述第一参考信号和所述估计值传送到所述定位设备; 使用定位装置建立第一参考位置，并且测量当前位置并产生与所测量的当前位置相对应的位置信号; 将所述另外的参考信号传送到所述定位装置; 产生定位驱动位置的另外的估计值; 将所述另外的估计值传送到所述定位装置; 建立另外的参考位置，并且测量另外的当前位置并产生与所测量的进一步的当前位置对应的另外的位置信号; 并以恒定的时间间隔循环重复这些步骤。

公开(公告)号：US06423960B1

公开(公告)日：2002-07-23

申请号：US09476589

申请日：1999-12-31

Applicant: Johann Engelhardt ,  Bernd Widzgowski

Inventor： Johann Engelhardt ,  Bernd Widzgowski

IPC: H01J4014

CPC classification number: G02B21/0084 ,  G02B21/004 ,  G02B21/0048

Abstract: The invention discloses a method and system for processing scan signals from a confocal microscope. The confocal microscope comprises an illumination source and a scanning device with a scanning mirror system. A control and processing unit is provided, which unit uses a plurality of programmable devices for the real time processing of digital signals. The control and processing unit has at least three input ports and one output port. A first detector generates analog signals corresponding to the light reflected from a specimen within the microscope and a second detector generates analog signals corresponding to the intensity of the light from the illumination source. In addition, a position signal of the scanning laser beam is provided to the control and processing unit. Analog-to-digital converters receive the analog signals, generate digital signals and provide the digital signals to the input ports of the control and processing unit.

Abstract translation: 本发明公开了一种从共焦显微镜处理扫描信号的方法和系统。 共焦显微镜包括照明源和具有扫描镜系统的扫描装置。 提供了一种控制和处理单元，该单元使用多个可编程设备来进行数字信号的实时处理。 控制和处理单元至少有三个输入端口和一个输出端口。 第一检测器产生对应于在显微镜内从样本反射的光的模拟信号，第二检测器产生对应于来自照明源的光的强度的模拟信号。 此外，扫描激光束的位置信号被提供给控制和处理单元。 模数转换器接收模拟信号，产生数字信号并将数字信号提供给控制和处理单元的输入端口。