公开(公告)号：US11828710B2

公开(公告)日：2023-11-28

申请号：US18103069

申请日：2023-01-30

申请人： SamanTree Medical SA

发明人： Bastien Rachet ,  Davor Kosanic ,  Etienne Shaffer

IPC分类号： G02B21/00 ,  G01N21/77 ,  G02B21/26 ,  G02B21/34 ,  G02B21/36 ,  G01N21/64 ,  G01N33/483 ,  G02B21/16 ,  G02B21/24

CPC分类号： G01N21/77 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/4833 ,  G02B21/004 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/0088 ,  G02B21/16 ,  G02B21/26 ,  G02B21/34 ,  G02B21/361 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2021/7786 ,  G01N2201/068 ,  G01N2201/0633 ,  G02B21/0012 ,  G02B21/0044 ,  G02B21/24

摘要： The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

公开(公告)号：US10007109B2

公开(公告)日：2018-06-26

申请号：US14219302

申请日：2014-03-19

申请人： Mehrdad Abolbashari ,  Faramarz Farahi

发明人： Mehrdad Abolbashari ,  Faramarz Farahi

IPC分类号： G02B27/00 ,  H04N13/02

CPC分类号： G02B27/005 ,  G02B21/004 ,  G02B21/0064 ,  G02B27/0075 ,  G02B27/4211 ,  H04N13/25 ,  H04N13/257 ,  H04N2209/048

摘要： The present disclosure provides wavelength discriminating imaging systems and methods that spatially separate (over different depths) the wavelength constituents of an image using a dispersive lens system or element, such that this spectral information may be exploited and used. The wavelength constituents of an image are deconstructed and identified over different depths using a dispersive lens system or element.

公开(公告)号：US20170343477A1

公开(公告)日：2017-11-30

申请号：US15607457

申请日：2017-05-27

申请人： Verily Life Sciences LLC

发明人： Charles Santori ,  Supriyo Sinha ,  Cheng-Hsun Wu ,  James Higbie ,  Seung Ah Lee

IPC分类号： G01N21/64 ,  A61B5/00 ,  G01J3/32 ,  G01J3/44

CPC分类号： G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/433 ,  G01J3/4406 ,  G01J2003/1243 ,  G01N21/6408 ,  G01N21/6445 ,  G01N21/6458 ,  G01N2021/6471 ,  G01N2201/0675 ,  G02B21/004 ,  G02B21/0076 ,  G02B21/16

摘要： Systems and methods for hyperspectral imaging are described. In one implementation, a hyperspectral imaging system includes a sample holder configured to hold a sample, an illumination system, and a detection system. The illumination system includes a light source configured to emit excitation light having one or more wavelengths, and a first set of optical elements that include a first spatial light modulator (SLM), at least one lens, and at least one dispersive element. The illumination system is configured to structure the excitation light into a predetermined two-dimensional pattern at a conjugate plane of a focal plane in the sample, spectrally disperse the structured excitation light in a first lateral direction, and illuminate the sample in an excitation pattern with the one or more wavelengths dispersed in the first lateral direction.

公开(公告)号：US09687154B2

公开(公告)日：2017-06-27

申请号：US14890681

申请日：2014-05-12

申请人： MIKROSKIN GMBH

发明人： Mark Weber ,  Juergen Valentin ,  Marcus Grigat

IPC分类号： A61B5/00 ,  A61B5/107 ,  G01B11/24 ,  G02B21/00 ,  G06T3/40 ,  G06T5/50

CPC分类号： A61B5/0068 ,  A61B5/0035 ,  A61B5/1079 ,  A61B5/441 ,  A61B2576/02 ,  G01B11/24 ,  G02B21/0028 ,  G02B21/004 ,  G02B21/006 ,  G06T3/4038 ,  G06T5/50 ,  G06T2207/30088

摘要： The invention relates to a method for the 3D measurement of the skin surface and near-surface skin layers by means of a confocal sensor with integrated color camera arranged in a handheld device, wherein said handheld device being moved by an operator via a sensor head to the location of the skin to be examined and a color image of the skin surface then being captured, whereupon the sensor being automatically changed over to confocal operation during which an image stack is generated by the simultaneous capturing of a multitude of all pixels necessary to create a complete image, said stack consisting of confocal images extending into the interior of the skin, with the entire area extending axially into the skin interior being scanned layer by layer in Z direction, wherein after capturing the measuring data an evaluation is performed resulting in a 3D image of the topography of the skin to be generated, and, moreover, from the image stack captured sectional images of the skin and skin volume are computed down to a depth of several millimeters and the images so created being displayed on a monitor.

公开(公告)号：US20160305926A1

公开(公告)日：2016-10-20

申请号：US15087601

申请日：2016-03-31

申请人： SamanTree Medical SA

发明人： Bastien Rachet ,  Davor Kosanic ,  Etienne Shaffer

IPC分类号： G01N33/483 ,  G01N21/64 ,  G02B21/16

CPC分类号： G01N21/77 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/4833 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2021/7786 ,  G01N2201/0633 ,  G01N2201/068 ,  G02B21/0012 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0044 ,  G02B21/0076 ,  G02B21/0088 ,  G02B21/16 ,  G02B21/24 ,  G02B21/26 ,  G02B21/34 ,  G02B21/361

摘要： The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

公开(公告)号：US20160296304A1

公开(公告)日：2016-10-13

申请号：US15038642

申请日：2014-11-24

申请人： SIRONA DENTAL SYSTEMS GMBH

发明人： Lukas WEWER ,  Mark WEBER ,  Georg WIORA

IPC分类号： A61C9/00 ,  G02B5/00 ,  A61B1/24 ,  G02B5/09 ,  G02B1/11 ,  H04N13/02 ,  G02B3/00

CPC分类号： A61C9/006 ,  A61B1/24 ,  G01B11/25 ,  G02B1/11 ,  G02B3/0006 ,  G02B5/003 ,  G02B5/09 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/008 ,  H04N13/204

摘要： The invention relates to an optical measuring system (1) and to a method for measuring an object (9) in a three-dimensional manner. The measuring system (1) has at least one lens array (5), a first convex lens (6) arranged downstream, a second convex lens (8) which is arranged further downstream and which faces an object (9) to be measured, and additionally a means (7) which absorbs incident light or deflects incident light out of the illuminating beam path and which is arranged upstream of the second convex lens (8) or on the second convex lens (8) on a second convex lens (8) face facing the first convex lens (6) in the region of the optical axis (10).

摘要翻译： 本发明涉及一种光学测量系统（1）以及用于以三维方式测量物体（9）的方法。 测量系统（1）具有至少一个透镜阵列（5），布置在下游的第一凸透镜（6），设置在下游并且面向待测物体（9）的第二凸透镜（8） 并且另外还包括吸收入射光或使入射光偏离出照射光束路径并且在第二凸透镜（8）上布置在第二凸透镜（8）或第二凸透镜（8）的上游的装置（7） ）面朝向所述光轴（10）的区域中的所述第一凸透镜（6）。

公开(公告)号：US20160274440A1

公开(公告)日：2016-09-22

申请号：US15034553

申请日：2014-11-07

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  ECOLE NORMALE SUPERIEURE

发明人： Stéphane DIEUDONNE ,  Benjamin MATHIEU

IPC分类号： G02F1/33 ,  G02F1/35 ,  G02B21/00 ,  G02B27/00

CPC分类号： G02F1/33 ,  G02B21/0036 ,  G02B21/004 ,  G02B21/0076 ,  G02B27/0031 ,  G02F1/3526 ,  G02F2001/291

摘要： The present invention concerns a laser scanning system (18) comprising: —a first acousto-optical deflector (30) deflecting a beam in a first direction (X) to obtain a first deflected beam and comprising a first acousto-optical crystal on which is applied an acoustic wave whose frequency varies over time according to a first law of command, and —a second acousto-optical deflector (32) deflected the first deflected beam in a second direction (Y), defining an angle comprised between 85° and 95° with the first direction, and comprising a second acousto-optical crystal on which is applied an acoustic wave whose frequency varies over time according to a second law of command, characterized in that the first law of command and the second law of command are chosen so that the average speed of the laser scanning system (18) is superior to 10 radians per second.

摘要翻译： 本发明涉及一种激光扫描系统（18），其包括： - 第一声光偏转器（30），用于沿第一方向（X）偏转光束以获得第一偏转光束，并且包括第一声光晶体，其上是 施加其频率根据第一定律定律随时间变化的声波，以及 - 第二声光偏转器（32）沿第二方向（Y）偏转所述第一偏转光束，所述第二方向限定了包括在85°和95°之间的角度 °，并且包括第二声光晶体，在其上施加声波，其频率根据第二定律定律随时间变化，其特征在于，选择第一定律和第二定律 使得激光扫描系统（18）的平均速度优于每秒10弧度。

公开(公告)号：US20160238827A1

公开(公告)日：2016-08-18

申请号：US14380392

申请日：2013-02-22

申请人： The U.S.A. of America, as represented by The Secretary, Dept. of Health and Human Services

发明人： Hari Shroff ,  Andrew York

IPC分类号： G02B21/00 ,  G01N21/64

CPC分类号： G02B21/0072 ,  G01N21/6458 ,  G01N2021/6478 ,  G01N2201/0633 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/004 ,  G02B21/0076

摘要： A multi-focal selective illumination microscopy (SIM) system for generating multi-focal patterns of a sample is disclosed. The multi-focal SIM system performs a focusing, scaling and summing operation on each multi-focal pattern in a sequence of multi-focal patterns that completely scan the sample to produce a high resolution composite image.

摘要翻译： 公开了一种用于产生样品的多焦点图案的多焦点选择性照明显微镜（SIM）系统。 多焦点SIM卡系统以完全扫描样本以产生高分辨率合成图像的多焦点图案序列对每个多焦点图案进行聚焦，缩放和求和操作。

公开(公告)号：US09310184B2

公开(公告)日：2016-04-12

申请号：US14500088

申请日：2014-09-29

申请人： Daniel Feldkhun

发明人： Daniel Feldkhun

IPC分类号： G01B9/02 ,  G01B11/24 ,  G01B21/04 ,  G01B11/25 ,  G02B27/00 ,  G02B27/48 ,  G02B21/00

CPC分类号： G01B9/02041 ,  G01B9/02082 ,  G01B11/2441 ,  G01B11/25 ,  G01B21/045 ,  G02B21/004 ,  G02B27/0025 ,  G02B27/48

摘要： Methods and systems are provided for suppressing speckle and/or diffraction artifacts in coherent structured illumination sensing systems. A coherent radiation pattern forms an interference pattern at an illumination image plane and illuminates an object. Radiation scattered or otherwise emitted by the object is detected to produce a signal, which is integrated in time. Coherent artifact suppression is attained by using a spatial modulator, such as an acousto-optic device, to vary a phase gradient at the illumination image plane during the signal integration time. Various embodiments are provided for purposes including without limitation: preserving the depth of field of the coherent illumination; using the same acousto-optic device for pattern generation and coherent artifact suppression; electronically controlling the effective spatial coherence of the illumination system; and reducing errors due to coherent artifacts in a laser-based three dimensional imaging system.

摘要翻译： 提供了用于抑制相干结构照明感测系统中斑点和/或衍射伪像的方法和系统。 相干辐射图形在照明像平面处形成干涉图案并照亮物体。 检测被物体散射或以其他方式发射的辐射，以产生一个在时间上集成的信号。 通过使用诸如声光装置的空间调制器在信号积分时间期间改变照明图像平面处的相位梯度来实现相干伪影抑制。 提供各种实施例用于包括但不限于：保持相干照明的景深的目的; 使用相同的声光装置进行图案生成和相干伪影抑制; 电子控制照明系统的有效空间相干性; 并且减少由于基于激光的三维成像系统中的相干伪影引起的误差。

公开(公告)号：US20150069267A1

公开(公告)日：2015-03-12

申请号：US14489727

申请日：2014-09-18

申请人： Illumina, Inc.

发明人： Wenyi Feng ,  Theofilos Kotseroglou ,  Mark Wang ,  Alexander Triener ,  Diping Che ,  Robert Kain

IPC分类号： G01N21/64

CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6421 ,  G02B21/0032 ,  G02B21/004

摘要： The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.

摘要翻译： 本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。 具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。 扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸 因为矩形检测器阵列足够短以在单个轴上实现共焦。