公开(公告)号：US20220249230A1

公开(公告)日：2022-08-11

申请号：US17721763

申请日：2022-04-15

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: An expandable prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an expandable valve body having an atrial end, a ventricular end opposite the atrial end, and an intermediate portion extending between the atrial end and the ventricular end. The valve body may include a plurality of struts intersecting at junctions. The prosthetic valve may also include a plurality of tissue anchoring legs extending from junctions within the intermediate portion of the valve body. At least one of the tissue anchoring legs may have a cross-sectional area which is larger by at least 20% than a cross-sectional area of a strut extending between the at least one tissue anchoring leg and an adjacent tissue anchoring leg.

公开(公告)号：US20200297486A1

公开(公告)日：2020-09-24

申请号：US16896858

申请日：2020-06-09

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve may include an annular valve body and atrial anchors and ventricular anchors extending from the valve body. An atrial anchor may include a pivoting portion configured to extend in an upstream direction when the prosthetic heart valve is in a delivery configuration and in a downstream direction when the prosthetic heart valve is in a deployed-anchor configuration. A portion of a ventricular anchor may be configured to abut the annular valve body when the prosthetic heart valve is arranged in the delivery configuration.

公开(公告)号：US20200246140A1

公开(公告)日：2020-08-06

申请号：US16636204

申请日：2018-07-04

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Yelena KASIMOV

IPC: A61F2/24

Abstract: A frame assembly (222) includes a tubular portion (32) that defines a lumen along an axis; a plurality of arms (46) coupled to the tubular portion at a first axial level, each of the arms extending radially outward from the tubular portion to a respective arm-tip; and a plurality of ventricular legs (50) that are coupled to the tubular portion at a second axial level, and that extend radially outward from the tubular portion. A first sheet (440) has a greater perimeter (446), and a smaller perimeter (448) that defines an opening. The first sheet is stitched onto the plurality of arms, with the opening aligned with the lumen. Subsequently, an outer perimeter (454) of a second sheet (450) is stitched to the greater perimeter of the first sheet. Subsequently, the second sheet is everted by passing an inner perimeter (452) of the second sheet around the arm-tips.

公开(公告)号：US20200129294A1

公开(公告)日：2020-04-30

申请号：US16730090

申请日：2019-12-30

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve may include an annular outer frame, an inner frame, and at least one connector configured to secure the outer frame to the inner frame. The connector may be spaced apart from at least one of the downstream end of the outer frame or the downstream end of the inner frame. The prosthetic heart valve may be configured to maintain a greater distance between the downstream ends of the outer and inner frames when the prosthetic heart valve is radially compressed than when the prosthetic heart valve is radially expanded.

公开(公告)号：US20200069424A1

公开(公告)日：2020-03-05

申请号：US16678355

申请日：2019-11-08

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an annular valve body having atrial anchoring arms and ventricular anchoring legs extending therefrom. The atrial anchoring arms and the ventricular anchoring legs may be configured for independent outward radial deflection. In some embodiments, at least one atrial anchoring arm may include first and third arm segments configured to extend in upstream directions and a second arm segment configured to extend in a downstream direction, the second arm segment situated between the first and third arm segments. The terminal end of the at least one atrial anchoring arm may be configured to be situated upstream from the rest of the arm when the prosthetic valve is radially-expanded.

公开(公告)号：US20200054451A1

公开(公告)日：2020-02-20

申请号：US16585349

申请日：2019-09-27

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a method of releasing a prosthetic valve from a delivery capsule within a heart may be provided. The delivery capsule may include a distal capsule portion and a proximal capsule portion. The method may include moving the distal capsule portion in a first direction to release ventricular anchoring legs of the prosthetic valve from the delivery capsule and moving the released legs into contact with a native mitral valve. The method may include moving the proximal capsule portion in a second direction to release atrial anchoring arms of the prosthetic valve from the delivery capsule, after contacting the mitral valve with the released legs. The method may include moving the distal capsule portion in the first direction to release an annular valve body of the prosthetic valve from the delivery capsule.

公开(公告)号：US20190388223A1

公开(公告)日：2019-12-26

申请号：US16559365

申请日：2019-09-03

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic valves and methods of using prosthetic valves may be provided. In one implementation, an expandable annular valve body may include a plurality of atrial anchoring arms and ventricular anchoring legs extending therefrom. The anchoring arms and anchoring legs may be configured to assume a delivery configuration in which they are radially constrained, such as within a delivery device, such that at least one atrial anchoring arm extends in a first upstream direction from the annular valve body, and a deployed configuration, in which they may deflect radially outward. In the deployed configuration, a first arm portion may be configured to deflect radially outward to extend in a downstream direction, and a second arm portion may be configured to deflect radially outward to extend in a second upstream direction, the first upstream direction being angled relative to the second upstream direction.

公开(公告)号：US20190328519A1

公开(公告)日：2019-10-31

申请号：US16507357

申请日：2019-07-10

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, an expandable prosthetic valve may be configured for implantation within a native heart valve. The prosthetic valve may include an expandable outer frame formed at least partially of outer frame struts. The prosthetic valve may also include an inner frame with tissue anchors extending therefrom, the inner frame being formed at least partially of inner frame struts. The struts along the downstream ends of the outer and inner frames may be arranged in undulating configurations to extend between peaks and troughs. A trough of the outer frame may be configured to be situated downstream from a peak of the inner frame.

公开(公告)号：US20190175342A1

公开(公告)日：2019-06-13

申请号：US16324339

申请日：2017-08-08

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI ,  Meni IAMBERGER ,  Aviram BAUM

IPC: A61F2/24

Abstract: Apparatus is provided for use with a heart of a subject, the apparatus including an inner stent frame defining a tubular portion, and an outer stent frame. The apparatus has a relaxed expanded state in which an outer-stent-frame relaxed expanded diameter defined by the outer stent frame is smaller than an inner-stent-frame expanded diameter defined by the tubular portion. Together, the inner stent frame and the outer stent frame define a frame assembly in which outer-frame coupling elements are fixed to inner-frame coupling elements. The frame assembly is expandable into an expanded state in which the tubular portion defines an inner-stent-frame constrained expanded diameter that is smaller than the inner-stent-frame relaxed expanded diameter. The frame assembly includes prosthetic leaflets secured to, and disposed within, the tubular portion, and has a compressed state in which the frame assembly is transluminally advanceable to the heart. Other embodiments are also described.

公开(公告)号：US20190167423A1

公开(公告)日：2019-06-06

申请号：US16269328

申请日：2019-02-06

Applicant: Cardiovalve Ltd.

Inventor： Ilia HARITON ,  Meni Iamberger ,  Yelena Kasimov ,  Boaz Harari ,  Aviram Baum

IPC: A61F2/24

Abstract: A valve body circumscribes a longitudinal axis and defines a lumen along the axis. Upstream arms are coupled to the valve body, and extend radially outward from the valve body to respective arm-tips. Downstream legs are coupled to the valve body, and extend radially outward from the valve body and toward the plurality of arms. A flexible pouch extends radially outward from the valve body. The arms and the legs narrow the pouch therebetween to form a narrowed portion of the pouch, thereby defining, in an interior space of the pouch: (a) an inner portion, radially inward from the narrowed portion, and in fluid communication with the lumen, and (b) an outer portion, radially outward from the narrowed portion, and in fluid communication with the inner portion via the narrowed portion. Other embodiments are also described.