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公开(公告)号：US20250152349A1
公开(公告)日：2025-05-15
申请号：US19026023
申请日：2025-01-16
Applicant: CARDIOVALVE LTD.
Inventor： Ilia HARITON , Meni IAMBERGER , Yelena KASIMOV , Boaz HARARI , Aviram BAUM
IPC: A61F2/24
Abstract: Apparatus is provided, including a frame assembly that includes a valve body that circumscribes a longitudinal axis and defines a lumen along the axis. A plurality of prosthetic leaflets are disposed within the lumen, and are arranged to facilitate one-way upstream-to-downstream fluid flow through the lumen. A flexible pouch defines an interior space therein. The pouch is shaped and is coupled to the frame assembly such that the pouch circumscribes the valve body, and has (1) a narrowed portion, (2) an inner portion of the interior space, radially inward from the narrowed portion, and in fluid communication with the lumen, and (3) an outer portion of the interior space, radially outward from the narrowed portion, and in fluid communication with the inner portion via the narrowed portion. Other embodiments are also described.
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公开(公告)号：US20230372090A1
公开(公告)日：2023-11-23
申请号：US18228229
申请日：2023-07-31
Applicant: CARDIOVALVE LTD.
Inventor： Ilia HARITON , Boaz HARARI , Meni IAMBERGER , Aviram BAUM
CPC classification number: A61F2/2418 , A61F2/2415 , A61F2/2412 , B23P15/001 , A61F2220/0075 , A61F2250/0039 , A61F2210/0014 , A61F2230/0069 , A61F2230/0093 , A61F2240/001 , A61F2/2436 , A61F2220/0025 , A61F2250/0063
Abstract: A unitary flexible sheet (612) is folded to define (i) a panel (608); (ii) a first tab (606a), having a first-tab outer layer and a first-tab inner layer, and protruding away from the panel; and (iii) a second tab (606b), having a second-tab outer layer and a second-tab inner layer, and protruding away from the panel. A commissural portion of a first prosthetic leaflet (58a), and a commissural portion of a second prosthetic leaflet (58b) are disposed between the first-tab inner layer and the second-tab inner layer. A first stitching (632) is stitched through the inner layer of each tab, and the commissural portion of each leaflet. A second stitching (634) is stitched through the outer and inner layers of each tab, and the commissural portion of each leaflet. The first-tab outer layer and the second-tab outer layer cover the first stitching. Other embodiments are also described.
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公开(公告)号：US20230059371A1
公开(公告)日：2023-02-23
申请号：US17797289
申请日：2021-02-04
Applicant: CARDIOVALVE LTD.
Inventor： Ilia HARITON , Oren SHUA , Meni IAMBERGER
Abstract: Apparatus is described that includes a kit. The kit includes a flexible catheter (22) and a support (40). The catheter is transfemorally advanceable to a heart of a subject and the support is dimensioned for percutaneous access to the heart. The support has a proximal end, an elongate portion, and a distal portion (41) having a catheter-engaging element (38). The catheter-engaging element is configured to reversibly engage the catheter in a manner that does not inhibit longitudinal advancement of the catheter. Other embodiments are also described.
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公开(公告)号：US20220338985A1
公开(公告)日：2022-10-27
申请号：US17839538
申请日：2022-06-14
Applicant: CARDIOVALVE LTD.
Inventor： Ilia HARITON , Boaz HARARI , Meni IAMBERGER
IPC: A61F2/24
Abstract: An apparatus for use at a native valve of a heart of a subject comprises a tubular frame (30) circumscribing a longitudinal axis to define a lumen, a valve member (62) disposed within the lumen and coupled to the tubular frame, an outer frame (40), and a pin (50). The outer frame is composed of a shape-memory alloy. The tubular frame and the pin are composed of a material that is not the shape-memory alloy. The outer frame comprises a flange (42), defines an eyelet (44), and is disposed radially outward from the tubular frame. The pin defines a shaft (52) and a head (54), and couples the outer frame to the tubular frame. The head is disposed against the outer frame, radially outward from the eyelet, the shaft extends from the head through the eyelet to the tubular frame, and the shaft is welded to the tubular frame.
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公开(公告)号：US20220175526A1
公开(公告)日：2022-06-09
申请号：US17399594
申请日：2021-08-11
Applicant: CARDIOVALVE LTD.
Inventor： Michael ALBITOV , Maxim KARALNIK , Meni IAMBERGER , Ilia HARITON , Tal HAMMER
Abstract: A delivery tool including a shaft and a proximal capsule and a distal capsule is dimensioned for percutaneous delivery to the heart. An open end of the proximal capsule faces the open end of the distal capsule. The capsules are coupled to the shaft in a manner that allows axial movement of the capsule with respect to the shaft. A prosthetic heart valve includes a tubular portion that defines a lumen and prosthetic leaflets disposed within the lumen. The prosthetic heart valve is restrainable in a compressed state by the delivery tool, such that a downstream end of the tubular portion is disposed within the distal capsule. The distal capsule is shaped so as to define an opening for visualizing ensheathing of at least a portion of the downstream end of the tubular portion within the distal capsule. Other embodiments are also described.
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Patent Agency Ranking
公开(公告)号：US20210196461A1
公开(公告)日：2021-07-01
申请号：US17181722
申请日：2021-02-22
Applicant: CARDIOVALVE LTD.
Inventor： Ilia HARITON , Boaz HARARI , Maxim KARALNIK , Michael ALBITOV , Meni IAMBERGER
Abstract: A delivery tool includes a nosepiece that is fixed to a shaft, and distal to an implant, and an expandable element proximal to the nosepiece. Maximally-expanded, the expandable element (i) has an expanded external diameter at its widest part that is smaller than the expanded internal diameter of a lumen of the frame of the implant, (ii) tapers proximally away from the widest part and from the nosepiece, and (iii) is dimensioned to slide proximally through the lumen of the implant in its expanded state, between leaflets of the implant, and out of the lumen. When non-expanded, the widest part of the expandable element has a non-expanded external diameter that is smaller than the expanded external diameter of the expandable element. In a compressed state of the implant a portion of the expandable element is disposed within the lumen of the frame. Other applications are also described.
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公开(公告)号：US20200146824A1
公开(公告)日：2020-05-14
申请号：US16746489
申请日：2020-01-17
Applicant: CARDIOVALVE LTD.
Inventor： Tal HAMMER , Meni IAMBERGER , Yuval ZIPORY , Michael ALBITOV , Tal REICH , Ilia HARITON
IPC: A61F2/24
Abstract: Embodiments of the present disclosure provide an apparatus comprising a delivery tool and a prosthetic valve, the prosthetic valve comprising a first frame, and a second frame coupled to the first frame. The delivery tool comprises a first catheter, a second catheter, and a rod. A steerable portion of the second catheter extends out of the first catheter, and a steerable distal portion of the rod extends out of the second catheter. An extracorporeal rod-controller is operably coupled to the rod such that operating the extracorporeal rod-controller steers the steerable distal portion of the rod. In a delivery state of the apparatus, the prosthetic valve is compressed onto the rod, distal to the distal end of the second catheter, and the apparatus is transfemorally and transseptally advanceable into a left atrium of a heart of a subject. Other embodiments are also described.
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公开(公告)号：US20190083263A1
公开(公告)日：2019-03-21
申请号：US16135619
申请日：2018-09-19
Applicant: CARDIOVALVE LTD.
Inventor： Ilia HARITON , Meni IAMBERGER , Aviram BAUM , Boaz HARARI
IPC: A61F2/24
Abstract: A prosthetic valve delivery system may be provided. The prosthetic valve delivery system may include a first catheter and a first steering mechanism configured to bend the first catheter within a first steering plane. The prosthetic valve delivery system may also include a second catheter coaxially arranged within the first catheter and a second steering mechanism configured to bend the second catheter within a second steering plane, different from the first steering plane. Moreover, the prosthetic valve delivery system may include a capsule positioned distal to both the first catheter and the second catheter. The capsule may be configured to retain a prosthetic valve therein during transvascular advancement of the capsule.
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公开(公告)号：US20240415647A1
公开(公告)日：2024-12-19
申请号：US18749731
申请日：2024-06-21
Applicant: CARDIOVALVE LTD.
Inventor： Tal HAMMER , Meni IAMBERGER , Yuval ZIPORY , Michael ALBITOV , Ilia HARITON , Aviram BAUM
Abstract: An implant includes a support frame, having a compressed state, and an expanded state in which the support frame defines an opening therethrough, and is dimensioned to be placed against an upstream surface of a native heart valve. The implant includes a valve frame having a compressed state, and an expanded state in which the valve frame defines a lumen therethrough, and including a valve member disposed within the lumen. The valve frame is coupled to the support frame via a flexible sheet such that when the support and valve frames are in their expanded state, the valve frame is not in contact with the support frame. The implant is housed in the catheter for implanting transfemorally, with the valve frame closer to a distal end of the catheter than the support frame is to the distal end of the catheter. Other embodiments are also described.
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公开(公告)号：US20230255764A9
公开(公告)日：2023-08-17
申请号：US17004693
申请日：2020-08-27
Applicant: CARDIOVALVE LTD.
Inventor： Ilia HARITON , Boaz HARARI
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2436 , A61F2/243 , A61F2/2409 , A61F2002/91575
Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a prosthetic valve may include an annular outer frame formed of struts intersecting at outer frame junctions, an inner frame situated within the outer frame and formed of struts intersecting at inner frame junctions, and a plurality of tissue anchors extending from the outer frame. The junctions along a downstream end of the outer frame may be spaced apart circumferentially from the junctions along a downstream end of the inner frame. The outer frame may include an anchor support strut extending between a downstream junction of the outer frame and a point of connection between one of the tissue anchors and the outer frame. The anchor support strut may be configured for placement parallel to a longitudinal axis of the prosthetic valve.
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