公开(公告)号：US20230293293A1

公开(公告)日：2023-09-21

申请号：US18125350

申请日：2023-03-23

Applicant: CARDIOVALVE LTD.

Inventor： Maxim KARALNIK ,  Michael ALBITOV ,  Oren SHUA ,  Meni IAMBERGER ,  Ilia HARITON

IPC: A61F2/24 ,  B21D39/04 ,  A61F2/95

CPC classification number: A61F2/2415 ,  A61F2/2427 ,  B21D39/048 ,  A61F2/9522 ,  A61F2/9525 ,  Y10T29/49865 ,  A61F2210/0014

Abstract: An assembly (10) for crimping a frame (56) of an implant (58) comprises a crimping device (20) with a base (22) and a crimping mechanism (24) that defines a crimping aperture (26). A bath (28) having a floor (30), and one or more side-walls (32) extending upward from the floor to a side-wall height defines a receptacle (18) that is shaped to receive a portion of the crimping device. The apparatus has an assembled state in which the portion of the crimping device has been received by the receptacle, the crimping device is held securely by the bath, and the aperture is below the side-wall height. Other embodiments are also described.

公开(公告)号：US20230218399A1

公开(公告)日：2023-07-13

申请号：US17956319

申请日：2022-09-29

Applicant: CARDIOVALVE LTD.

Inventor： Yonatan KISLEV ,  Or COHEN ,  Meni IAMBERGER

IPC: A61F2/24

CPC classification number: A61F2/2472 ,  A61F2/2415

Abstract: A method for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. Using a computer processor, for each leaflet of the aggregate, in response to an image parameter of the leaflet, a leaflet-flexibility value is derived. A group size value is provided to the processor. Using the processor, at least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. Each of the leaflet groups includes a number of leaflets equal to the group size value. Using the processor, an indication of the designated leaflet groups is outputted. Other embodiments are also described.

公开(公告)号：US20230137909A1

公开(公告)日：2023-05-04

申请号：US18090058

申请日：2022-12-28

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Yelena KASIMOV ,  Boaz HARARI ,  Aviram BAUM

IPC: A61F2/24

Abstract: A valve body circumscribes a longitudinal axis and defines a lumen along the axis. Upstream arms are coupled to the valve body, and extend radially outward from the valve body to respective arm-tips. Downstream legs are coupled to the valve body, and extend radially outward from the valve body and toward the plurality of arms. A flexible pouch extends radially outward from the valve body. The arms and the legs narrow the pouch therebetween to form a narrowed portion of the pouch, thereby defining, in an interior space of the pouch: (a) an inner portion, radially inward from the narrowed portion, and in fluid communication with the lumen, and (b) an outer portion, radially outward from the narrowed portion, and in fluid communication with the inner portion via the narrowed portion. Other embodiments are also described.

公开(公告)号：US20220133342A1

公开(公告)日：2022-05-05

申请号：US17429446

申请日：2019-12-23

Applicant: CARDIOVALVE LTD.

Inventor： Michael ALBITOV ,  Meni IAMBERGER ,  Ilia HARITON

IPC: A61B17/32

Abstract: Apparatus is described that includes a blade assembly (20) for conditioning ex vivo pericardial tissue from which fibers extend. The apparatus includes a blade head (26) that includes a blade a may (28) and a face (30) defining gaps (32) therein. The gaps are dimensioned to facilitate protrusion therethrough of fibers into the blade head, such that movement of the blade array, with respect to the face, shears the fibers. The blade assembly is configured to be used while the tissue and the blade array are submerged in a liquid (140) with the fibers facing upward, and with the face facing downward. The apparatus is configured to provide, while the blade array is submerged in the liquid, a suction force that sucks the liquid into the blade head via the gaps, and discharges a refuse liquid through a lateral exhaust hole (24). Other embodiments are also described.

公开(公告)号：US20190083246A1

公开(公告)日：2019-03-21

申请号：US16135770

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: An expandable prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an expandable annular valve body. The valve body may include an atrial inlet opening and a ventricular outlet opening. The valve body may additionally include a plurality of tissue anchors extending from the valve body. The prosthetic valve may additionally include a flexible annular protective sleeve positioned about the rim of the valve body outlet opening and affixed to the outlet opening.

公开(公告)号：US20240415647A1

公开(公告)日：2024-12-19

申请号：US18749731

申请日：2024-06-21

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni IAMBERGER ,  Yuval ZIPORY ,  Michael ALBITOV ,  Ilia HARITON ,  Aviram BAUM

IPC: A61F2/24 ,  A61F2/82

Abstract: An implant includes a support frame, having a compressed state, and an expanded state in which the support frame defines an opening therethrough, and is dimensioned to be placed against an upstream surface of a native heart valve. The implant includes a valve frame having a compressed state, and an expanded state in which the valve frame defines a lumen therethrough, and including a valve member disposed within the lumen. The valve frame is coupled to the support frame via a flexible sheet such that when the support and valve frames are in their expanded state, the valve frame is not in contact with the support frame. The implant is housed in the catheter for implanting transfemorally, with the valve frame closer to a distal end of the catheter than the support frame is to the distal end of the catheter. Other embodiments are also described.

公开(公告)号：US20200163760A1

公开(公告)日：2020-05-28

申请号：US16637166

申请日：2018-08-07

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM

IPC: A61F2/24 ,  B23P15/00

Abstract: A unitary flexible sheet is folded to defines a panel, and first and second tabs. Each of the tabs has an inner layer and an outer layer. Commissural portions of prosthetic leaflets are sandwiched between inner layers of the first and second tabs. The tabs protrude from a first side of the panel, and are shaped such that progressively downstream parts of each tab protrude progressively further away from the panel portion. Other embodiments are also described.

公开(公告)号：US20200046496A1

公开(公告)日：2020-02-13

申请号：US16656790

申请日：2019-10-18

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni IAMBERGER ,  Yaron HERMAN ,  Yuval ZIPORY ,  Eran HOFFER ,  Michael ALBITOV ,  Natalia KRUGLOVA ,  Tal REICH ,  Ilia HARITON ,  Aviram BAUM

IPC: A61F2/24

Abstract: A prosthetic valve includes a tubular valve body, snares, and an upstream support. A native valve of a heart of a subject is disposed between an atrium and a ventricle of the heart, and has an annulus and leaflets. The prosthetic valve is advanced to the heart while in a compressed state. The prosthetic valve is positioned within the heart such that the snares are disposed upstream of the annulus and leaflets. The snares are expanded radially outwardly upstream of the leaflets. Subsequently, the prosthetic valve is moved in a downstream direction such that the snares become disposed downstream of the leaflets. While the snares remain downstream of the leaflets, the upstream support is expanded within the atrium, and the upstream support is placed against an upstream surface of the annulus. Other embodiments are also described.

公开(公告)号：US20190083251A1

公开(公告)日：2019-03-21

申请号：US16136082

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic valves and methods of implanting prosthetic valves may be provided, including an expandable prosthetic valve for implantation within a native heart valve. The prosthetic valve may include an annular valve body and atrial anchoring arms configured to extend radially outward from the annular valve body. Each atrial anchoring arm may have a proximal arm end and a distal arm end. The flexibility of at least one atrial anchoring arm may vary substantially from the proximal arm end thereof to the distal arm end thereof. The prosthetic valve may also include a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. Each ventricular anchoring leg may have a proximal leg end and a distal leg end. Each ventricular anchoring leg may have a substantially constant flexibility from the proximal leg end to the distal leg end.

公开(公告)号：US20190083250A1

公开(公告)日：2019-03-21

申请号：US16136074

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: A prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an annular valve body, as well as a plurality of ventricular anchoring legs and a plurality of atrial anchoring arms configured to extend radially outward from the annular valve body. The ventricular anchoring legs and grasping segments of the atrial anchoring arms may be configured to substantially restrict axial movement of the annular valve body within the native heart valve. In addition, anchoring segments of the atrial anchoring arms may be configured for lateral deformation relative to the native heart valve.