公开(公告)号：US20230137909A1

公开(公告)日：2023-05-04

申请号：US18090058

申请日：2022-12-28

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Yelena KASIMOV ,  Boaz HARARI ,  Aviram BAUM

IPC: A61F2/24

Abstract: A valve body circumscribes a longitudinal axis and defines a lumen along the axis. Upstream arms are coupled to the valve body, and extend radially outward from the valve body to respective arm-tips. Downstream legs are coupled to the valve body, and extend radially outward from the valve body and toward the plurality of arms. A flexible pouch extends radially outward from the valve body. The arms and the legs narrow the pouch therebetween to form a narrowed portion of the pouch, thereby defining, in an interior space of the pouch: (a) an inner portion, radially inward from the narrowed portion, and in fluid communication with the lumen, and (b) an outer portion, radially outward from the narrowed portion, and in fluid communication with the inner portion via the narrowed portion. Other embodiments are also described.

公开(公告)号：US20200315797A1

公开(公告)日：2020-10-08

申请号：US16907615

申请日：2020-06-22

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve configured to transition between radially compressed and radially expanded configurations may be provided. The prosthetic heart valve may include an outer frame, an inner frame, and at least one tissue anchor extending from at least one of the frames. The prosthetic heart valve may be configured to maintain a first distance between the downstream ends of the inner and outer frames when the prosthetic heart valve is in the radially compressed configuration and a second distance between the downstream ends of the inner and outer frames when the prosthetic heart valve is in the radially expanded configuration, the first distance being greater than the second distance.

公开(公告)号：US20190083246A1

公开(公告)日：2019-03-21

申请号：US16135770

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: An expandable prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an expandable annular valve body. The valve body may include an atrial inlet opening and a ventricular outlet opening. The valve body may additionally include a plurality of tissue anchors extending from the valve body. The prosthetic valve may additionally include a flexible annular protective sleeve positioned about the rim of the valve body outlet opening and affixed to the outlet opening.

公开(公告)号：US20230255764A9

公开(公告)日：2023-08-17

申请号：US17004693

申请日：2020-08-27

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2/243 ,  A61F2/2409 ,  A61F2002/91575

Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a prosthetic valve may include an annular outer frame formed of struts intersecting at outer frame junctions, an inner frame situated within the outer frame and formed of struts intersecting at inner frame junctions, and a plurality of tissue anchors extending from the outer frame. The junctions along a downstream end of the outer frame may be spaced apart circumferentially from the junctions along a downstream end of the inner frame. The outer frame may include an anchor support strut extending between a downstream junction of the outer frame and a point of connection between one of the tissue anchors and the outer frame. The anchor support strut may be configured for placement parallel to a longitudinal axis of the prosthetic valve.

公开(公告)号：US20200163761A1

公开(公告)日：2020-05-28

申请号：US16776581

申请日：2020-01-30

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Embodiments of the present disclosure include apparatus including a percutaneous delivery capsule and prosthetic valve. The prosthetic valve includes a frame assembly that includes a tubular portion, and a plurality of atrial arms that extend away from the tubular portion. A plurality of prosthetic leaflets are attached to the tubular portion, and are disposed within a lumen defined by the tubular portion. When the prosthetic valve is in a compressed state and is housed by the capsule, each of the atrial arms extends, in a serpentine shape, along the capsule and away from the tubular portion. Other embodiments are also described.

公开(公告)号：US20200046497A1

公开(公告)日：2020-02-13

申请号：US16660231

申请日：2019-10-22

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a method of implanting a prosthetic valve within a native heart valve may be provided. The method may include delivering the prosthetic valve into a heart chamber while the prosthetic valve is constrained in a radially-contracted delivery configuration. The method may also include unconstraining ventricular tissue anchors and atrial tissue anchors of the prosthetic valve while maintaining an annular valve body of the prosthetic valve in the delivery configuration. The method may also include unconstraining the annular valve body from the delivery configuration while the unconstrained atrial tissue anchors and ventricular tissue anchors are positioned within an atrium and a ventricle, respectively. Unconstraining the annular valve body may decrease a longitudinal distance between the ventricular tissue anchors and atrial tissue anchors to secure the prosthetic valve within the native heart valve.

公开(公告)号：US20190083251A1

公开(公告)日：2019-03-21

申请号：US16136082

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic valves and methods of implanting prosthetic valves may be provided, including an expandable prosthetic valve for implantation within a native heart valve. The prosthetic valve may include an annular valve body and atrial anchoring arms configured to extend radially outward from the annular valve body. Each atrial anchoring arm may have a proximal arm end and a distal arm end. The flexibility of at least one atrial anchoring arm may vary substantially from the proximal arm end thereof to the distal arm end thereof. The prosthetic valve may also include a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. Each ventricular anchoring leg may have a proximal leg end and a distal leg end. Each ventricular anchoring leg may have a substantially constant flexibility from the proximal leg end to the distal leg end.

公开(公告)号：US20190083250A1

公开(公告)日：2019-03-21

申请号：US16136074

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: A prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an annular valve body, as well as a plurality of ventricular anchoring legs and a plurality of atrial anchoring arms configured to extend radially outward from the annular valve body. The ventricular anchoring legs and grasping segments of the atrial anchoring arms may be configured to substantially restrict axial movement of the annular valve body within the native heart valve. In addition, anchoring segments of the atrial anchoring arms may be configured for lateral deformation relative to the native heart valve.

公开(公告)号：US20190083244A1

公开(公告)日：2019-03-21

申请号：US16135599

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: An expandable prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an expandable valve body having an atrial end, a ventricular end opposite the atrial end, and an intermediate portion extending between the atrial end and the ventricular end. The valve body may include a plurality of struts intersecting at junctions. The prosthetic valve may also include a plurality of tissue anchoring legs extending from junctions within the intermediate portion of the valve body. At least one of the tissue anchoring legs may have a cross-sectional area which is larger by at least 20% than a cross-sectional area of a strut extending between the at least one tissue anchoring leg and an adjacent tissue anchoring leg.

公开(公告)号：US20250152349A1

公开(公告)日：2025-05-15

申请号：US19026023

申请日：2025-01-16

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Yelena KASIMOV ,  Boaz HARARI ,  Aviram BAUM

IPC: A61F2/24

Abstract: Apparatus is provided, including a frame assembly that includes a valve body that circumscribes a longitudinal axis and defines a lumen along the axis. A plurality of prosthetic leaflets are disposed within the lumen, and are arranged to facilitate one-way upstream-to-downstream fluid flow through the lumen. A flexible pouch defines an interior space therein. The pouch is shaped and is coupled to the frame assembly such that the pouch circumscribes the valve body, and has (1) a narrowed portion, (2) an inner portion of the interior space, radially inward from the narrowed portion, and in fluid communication with the lumen, and (3) an outer portion of the interior space, radially outward from the narrowed portion, and in fluid communication with the inner portion via the narrowed portion. Other embodiments are also described.