公开(公告)号：US09522920B2

公开(公告)日：2016-12-20

申请号：US14313148

申请日：2014-06-24

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Alexandre Côté ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Michael Charles Hewitt ,  Yves Leblanc ,  Christopher G. Nasveschuk ,  Alexander M. Taylor ,  Rishi G. Vaswani

IPC: A61K31/55 ,  C07D498/04 ,  C07D498/14 ,  C07D498/20 ,  C07D498/22 ,  C07K14/47 ,  A61K31/424

CPC classification number: C07D498/04 ,  A61K31/424 ,  A61K31/55 ,  C07D498/14 ,  C07D498/20 ,  C07D498/22 ,  C07K14/4702

Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US20160333016A1

公开(公告)日：2016-11-17

申请号：US15155749

申请日：2016-05-16

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Andrew Cook ,  Les A. Dakin ,  Martin Duplessis ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk ,  Rishi G. Vaswani

IPC: C07D487/04 ,  C07D405/14 ,  C07D401/14 ,  C07D401/12 ,  C07D471/04

CPC classification number: A61K31/4545 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/06 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

公开(公告)号：US20160317632A1

公开(公告)日：2016-11-03

申请号：US15095985

申请日：2016-04-11

Applicant: GENENTECH, INC. ,  CONSTELLATION PHARMACEUTICALS, INC.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Steven Bellon ,  Andrea Cochran ,  Alexandre Cote ,  Terry Crawford ,  Benjamin Fauber ,  Srimoyee Ghosh ,  Jean-Christophe Harmange ,  Georgia Hatzivassiliou ,  Hariharan Jayaram ,  Jeong Kim ,  Jose M. Lora ,  Steven Magnuson ,  Ira Mellman ,  Anthony F. Romero ,  Alexander M. Taylor ,  Vickie Tsui

IPC: A61K39/00 ,  A61K31/498 ,  G01N33/50 ,  A61K31/538

CPC classification number: A61K39/0011 ,  A61K31/498 ,  A61K31/538 ,  C07K14/475 ,  G01N33/5011

Abstract: The present invention relates to use of CBP/EP300 bromodomain inhibitors for the treatment of cancer.

Abstract translation: 本发明涉及CBP / EP300溴结构域抑制剂用于治疗癌症的用途。

公开(公告)号：US09371331B2

公开(公告)日：2016-06-21

申请号：US14661797

申请日：2015-03-18

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Andrew S. Cook ,  Les A. Dakin ,  Martin Duplessis ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk ,  Rishi G. Vaswani

IPC: A61K31/535 ,  C07D401/00 ,  C07D487/04 ,  C07D401/14 ,  C07D401/12 ,  C07D417/04 ,  C07D417/14 ,  C07D405/14 ,  C07D409/06 ,  C07D471/04

CPC classification number: A61K31/4545 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/06 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

公开(公告)号：US09206128B2

公开(公告)日：2015-12-08

申请号：US14358558

申请日：2012-11-19

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Andrew S. Cook ,  Alexandre Gagnon ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk

IPC: C07D213/61 ,  C07D213/64 ,  C07D221/18 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

CPC classification number: C07D213/64 ,  C07D221/18 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

公开(公告)号：US09051269B2

公开(公告)日：2015-06-09

申请号：US14358455

申请日：2012-11-19

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Alexandre Gagnon ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk

IPC: C07D213/62 ,  C07D213/64 ,  C07D405/12 ,  C07D401/12

CPC classification number: C07D213/64 ,  C07D213/81 ,  C07D401/12 ,  C07D405/12

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

Abstract translation: 本文提供了用于调节甲基修饰酶的组合物及其用途。

公开(公告)号：US10358437B2

公开(公告)日：2019-07-23

申请号：US15449706

申请日：2017-03-03

Applicant: GENENTECH, INC. ,  CONSTELLATION PHARMACEUTICALS, INC.

Inventor： Brian K. Albrecht ,  Alexandre Cote ,  Terry Crawford ,  Martin Duplessis ,  Andrew Charles Good ,  Yves LeBlanc ,  Steven Magnuson ,  Christopher G. Nasveschuk ,  Richard Pastor ,  F. Anthony Romero ,  Alexander M. Taylor

IPC: C07D249/12 ,  C07D403/04 ,  C07D403/12 ,  C07D401/04 ,  C07D401/12 ,  A61K31/53 ,  A61K31/4196 ,  A61P35/00 ,  C07D253/075 ,  A61K45/06

Abstract: The present invention relates to methods for treating PCAF mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R3-R6, X, and each Re have any of the values defined in the specification. Also included are novel compounds of formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：USRE47428E1

公开(公告)日：2019-06-11

申请号：US15878663

申请日：2018-01-24

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Les A. Dakin ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk ,  Rishi G. Vaswani

IPC: C07D401/12 ,  C07D401/14 ,  C07D487/04 ,  C07D417/04 ,  C07D417/14 ,  C07D405/14 ,  C07D471/04 ,  C07D409/06 ,  A61K31/4545

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

公开(公告)号：US10280149B2

公开(公告)日：2019-05-07

申请号：US15643808

申请日：2017-07-07

Applicant: GENENTECH, INC. ,  CONSTELLATION PHARMACEUTICALS, INC.

Inventor： Brian K. Albrecht ,  Alexandre Cote ,  Victor Gehling ,  Vickie Hsiao-Wei Tsui ,  James Richard Jr. Kiefer ,  Jun Liang ,  Steven Magnuson ,  Christopher G. Nasveschuk ,  Richard Pastor ,  F. Anthony Romero ,  Alexander M. Taylor ,  Birong Zhang

IPC: C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D241/04 ,  C07D211/30

Abstract: The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US20190125737A1

公开(公告)日：2019-05-02

申请号：US15994005

申请日：2018-05-31

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Andrew Cook ,  Les A. Dakin ,  Martin Duplessis ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk ,  Rishi G. Vaswani

IPC: A61K31/4545 ,  C07D471/04 ,  C07D409/06 ,  C07D405/14 ,  C07D401/14 ,  C07D487/04 ,  C07D417/04 ,  C07D401/12 ,  C07D417/14

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.