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公开(公告)号：US10202354B2
公开(公告)日：2019-02-12
申请号：US15643805
申请日：2017-07-07
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Alexandre Cote , Victor Gehling , Vickie Hsiao-Wei Tsui , James Richard Jr. Kiefer , Jun Liang , Steven Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Alexander M. Taylor
IPC: C07D233/44 , C07D235/02 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/08
Abstract: The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US10150767B2
公开(公告)日：2018-12-11
申请号：US15592017
申请日：2017-05-10
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC: C07D471/04 , A61K31/437 , C07D519/00 , A61K31/4985 , A61K31/496 , A61K31/4545 , A61K45/06
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US10016405B2
公开(公告)日：2018-07-10
申请号：US15257275
申请日：2016-09-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/4545 , C07D401/14 , C07D401/12 , C07D417/04 , C07D487/04 , C07D417/14 , C07D405/14 , C07D409/06 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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44.发明授权公开(公告)号：US09969716B2
公开(公告)日：2018-05-15
申请号：US14911343
申请日：2014-08-15
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D401/14 , C07D401/12 , C07D405/14 , C07D413/14
CPC classification number: C07D401/14 , C07D401/12 , C07D405/14 , C07D413/14
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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Patent Agency Ranking
公开(公告)号：US20180022707A1
公开(公告)日：2018-01-25
申请号：US15643805
申请日：2017-07-07
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Alexandre Cote , Victor Gehling , Vickie Hsiao-Wei Tsui , James Richard Jr. Kiefer , Jun Liang , Steven Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Alexander M. Taylor
IPC: C07D233/44 , C07D487/08 , C07D413/12 , C07D417/12 , C07D403/12 , C07D409/12
CPC classification number: C07D233/44 , C07D235/02 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/08
Abstract: The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09745305B2
公开(公告)日：2017-08-29
申请号：US14769471
申请日：2014-03-12
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Alexandre Côté , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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47.发明申请INDOLE DERIVATIVES AS MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF 有权作为甲基修饰酶的调节剂的吲哚衍生物，其组合物及其用途公开(公告)号：US20160185757A1
公开(公告)日：2016-06-30
申请号：US14911343
申请日：2014-08-15
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D401/14 , C07D413/14 , C07D405/14
CPC classification number: C07D401/14 , C07D401/12 , C07D405/14 , C07D413/14
Abstract: Agents of formulas (I)/(II)/(III) for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Abstract translation: 本文提供了用于调节甲基修饰酶的式（I）/（II）/（III）的试剂，其组合物和用途。
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公开(公告)号：US20150368229A1
公开(公告)日：2015-12-24
申请号：US14839273
申请日：2015-08-28
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D401/14 , C07D471/04 , C07D405/14
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Abstract translation: 本文提供了用于调节甲基修饰酶的组合物及其用途。
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公开(公告)号：US20150315148A1
公开(公告)日：2015-11-05
申请号：US14707874
申请日：2015-05-08
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Gagnon , Jean-Christophe Harmange , Christopher G. Nasveschuk
IPC: C07D213/64 , C07D213/81 , C07D401/12 , C07D405/12
CPC classification number: C07D213/64 , C07D213/81 , C07D401/12 , C07D405/12
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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