公开(公告)号：US20220034748A1

公开(公告)日：2022-02-03

申请号：US17276981

申请日：2019-09-09

Applicant: Cytiva Sweden AB

Inventor： Sameera Simha Hindupur ,  Manoj Kumar Ramakrishna ,  Andreas Castan ,  Swapnil Puranik ,  Klaus Gebauer

IPC: G01M3/28 ,  B29C65/82 ,  B29C65/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34

Abstract: The present invention relates to a computer implemented method for determining a weld integrity test result performed by a system configured to aseptically transferring cells to a container (BR), the method comprising welding (710) a vial to a connector to obtain a fluid-tight seal between the vial (V) and a connector (C), the connector being provided with a pair of conduits each having one end protruding through the connector and into the vial, sealing (720) an opposite end of one of the conduits, generating (730) a fluid pressure different to an ambient fluid pressure at an opposite end of the other conduit, measuring (740) a fluid pressure within at least one of the conduits, determining (750) a fluid pressure change based on the ambient pressure and the measured fluid pressure, determining (760) the weld integrity test result as pass or as fail based on the fluid pressure change.

公开(公告)号：US20210387189A1

公开(公告)日：2021-12-16

申请号：US17281727

申请日：2019-10-16

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer

IPC: B01L3/00

Abstract: The present invention relates to a bioprocessing fluid sensor arrangement (100) for sensing fluidic properties in a process fluid path with a sensor (S), configured for aseptically connecting the sensor with at least one conditioning fluid while separating said sensor from the process fluid to at least one conditioning fluid e.g. for calibration, cleaning, regenerating and/or storing the sensor, the arrangement comprising a process fluid path (PF) having a process fluid inlet (PI) and a process fluid outlet (PO); a sensor (S) arranged in the process fluid path (PF); a bypass fluid path (BF) in the process fluid path (PF), for bypassing the sensor (S); a conditioning or cleaning fluid path (CF) having an inlet (CI) and an outlet (CO) each aseptically and fluidically connected to the process fluid path (PF), one on each side of the sensor (S); and flow controls (FC) for controlling the flow of fluids, whereby fluids can be controlled to flow either in the process fluid path (PF) via the sensor (S), or in the bypass fluid path (BF) omitting the sensor from the fluid path (PF), or in the conditioning or cleaning fluid path (CF) including the sensor in said flow but omitting the remaining process fluid path (PF) and bypass fluid path (BF).

公开(公告)号：US20210215286A1

公开(公告)日：2021-07-15

申请号：US17056510

申请日：2019-05-29

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer

IPC: F16L35/00 ,  A61M39/16

Abstract: The present invention relates to a connector for substantially aseptic connection, said connector comprising a connector member (1) having a connection end (13) and a coupling end (12), wherein the coupling end (12) comprises a coupling element (15) for engaging a similar coupling element (15′) on a similar connector (100) to form a first seal (B), and a cover (2) arranged to enclose the coupling end (12) for providing an aseptic seal that separates the coupling end (12) from a surrounding, the cover (2) comprising at least two cover portions (21A, 22A), each cover portion (21A, 22A) being configured to be successively-positioned on or adjacent the coupling end (12) of the connector member (1), wherein each cover portion (21A, 22A) comprises a seal member (21, 22) for engaging a similar seal member on a similar connector thereby to form a second seal (A) when so positioned on or adjacent the coupling end (12) of the connector member (1). The invention also relates to a method for connecting and disconnecting two such connectors.

公开(公告)号：US20210162317A1

公开(公告)日：2021-06-03

申请号：US17268497

申请日：2019-08-20

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer ,  Andreas Lundin ,  Fredrik Lundström

IPC: B01D15/18 ,  G01N30/20 ,  G01N30/38 ,  G01N30/46

Abstract: A connection device (1; 101) configured for connecting a separation system (3) with a separation device (5), wherein a fluid can be flowed from a separation system outlet connection (19), through a bypass fluid path (27) of the connection device to the separation system inlet connection (15) while a connected separation device (5) is by passed. For achieving this at least one of an inlet and an outlet valve (31, 33) provided in the connection device is provided in a closed state and at least one bypass valve (35, 35a, 35b) provided in the connection device is provided in an open state.

公开(公告)号：US20210162192A1

公开(公告)日：2021-06-03

申请号：US17174533

申请日：2021-02-12

Applicant: Cytiva Sweden AB

Inventor： Eric Faldt ,  Klaus Gebauer

IPC: A61M39/10 ,  A61M39/16 ,  F16L39/00 ,  A61M39/18

Abstract: Aseptic connectors are described. An aseptic connector includes a first connection unit and a second connection unit provided with at least one first and second openings orientated to substantially coincide when said first and second connection units are connected to each other. The first and second openings are sealed by at least one film, so that the contact between the film and each connection unit is aseptic. The at least one film is adapted to be mated with a corresponding film on the other connection unit; and the mated films are adapted to be pulled out together two and two after mating such that corresponding first and second openings are mated aseptically.