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    Serpentine transmembrane antigens expressed in human cancers and uses thereof
    44.
    发明授权
    Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
    在人类癌症中表达的蛇纹石跨膜抗原及其用途

    公开(公告)号：US07455991B2

    公开(公告)日：2008-11-25

    申请号：US10752421

    申请日：2004-01-05

    申请人： Daniel E. H. Afar ,  Rene S. Hubert ,  Arthur B. Raitano ,  Douglas Saffran ,  Steven Chappell Mitchell

    发明人： Daniel E. H. Afar ,  Rene S. Hubert ,  Arthur B. Raitano ,  Douglas Saffran ,  Steven Chappell Mitchell

    IPC分类号： C07H21/02 ,  C12N15/63

    CPC分类号： C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/82 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/027 ,  G01N33/57434 ,  Y10S435/975

    摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

    摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（ Six 上皮 Prostate的抗原。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。