公开(公告)号：US08067021B2

公开(公告)日：2011-11-29

申请号：US12204731

申请日：2008-09-04

申请人： Benjamin Marcus Buehrer ,  Paul Hamilton ,  Dalia Juzumiene ,  Shrikumar Nair ,  Yuchen Chen

发明人： Benjamin Marcus Buehrer ,  Paul Hamilton ,  Dalia Juzumiene ,  Shrikumar Nair ,  Yuchen Chen

IPC分类号： A61F13/00 ,  A61K38/00 ,  A61K38/18 ,  A61K38/10 ,  A61K38/16 ,  C07K14/475

CPC分类号： C07K14/71 ,  A61K9/0024 ,  A61K38/00 ,  A61L27/227 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/414 ,  A61L2300/606 ,  C07K2319/20

摘要： The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.

摘要翻译： 目前公开的主题涉及用于非共价定位的纤维结缔组织诱导生长因子到植入物表面的肽组合物，该组合物包含与对具有结合的肽偶联的植入物的表面材料具有结合亲和力的肽 对纤维结缔组织诱导生长因子的亲和力。 提供用于递送有效促进纤维结缔组织修复和纤维结缔组织形成的纤维结缔组织诱导生长因子GDF-7的方法。 还提供了通过使组合物与植入物的表面接触来将肽组合物施用于植入物的方法; 和包含该组合物的试剂盒。

公开(公告)号：US20110124827A1

公开(公告)日：2011-05-26

申请号：US12518023

申请日：2009-06-05

申请人： John Stephen Godsmark ,  Georges Marie Karel Mathys ,  Paul Hamilton ,  Stephen Harold Brown ,  Yeo-Meng Lim

发明人： John Stephen Godsmark ,  Georges Marie Karel Mathys ,  Paul Hamilton ,  Stephen Harold Brown ,  Yeo-Meng Lim

IPC分类号： C08F2/01

CPC分类号： C10G50/00 ,  C07C2/12 ,  C10G2300/1088 ,  C10G2300/1092 ,  C10G2400/20 ,  C10G2400/22

摘要： In the oligomerisation of olefins in a tubular reactor employing a molecular sieve catalyst, the temperature of the reaction is monitored and the space velocity of the olefin feed to the reactor is reduced as the temperature increases. This has been found to increase catalyst life and lead to extended production runs. Further extensions of the production run are achieved by improving reactor operating stability as the end of the production run approaches.

摘要翻译： 在使用分子筛催化剂的管式反应器中烯烃的低聚反应中，监测反应的温度，并且随着温度的升高，进入反应器的烯烃进料的空速降低。 已经发现这可以增加催化剂寿命并导致生产延长。 生产运行的进一步扩展是通过在生产运行结束时改进反应堆运行稳定性来实现的。

公开(公告)号：US07930235B2

公开(公告)日：2011-04-19

申请号：US11333789

申请日：2006-01-17

申请人： J. Scott Perry ,  Wallace C. Turbeville ,  Paul Hamilton

发明人： J. Scott Perry ,  Wallace C. Turbeville ,  Paul Hamilton

IPC分类号： G06Q40/00

CPC分类号： G06Q40/00 ,  G06Q40/04

摘要： An agency payment system for transactions covered by a virtual market control entity between participants. The system determines all payments required to be made by each virtual market control entity participant on a given day. It nets all of each of the participant's required payments to be made with the payments received by the virtual market control entity on the previous day due to each participant to obtain a net cash movement, either from the virtual market control entity to the participant's account or from the participant's account to the virtual market control entity. It transfers between the participant's account and the virtual market control entity's account and each participant's account the net cash movements to the virtual market control entity's account. It then transfers between the virtual market control entity's account and each participant's account the net cash movements to the participant's account.

摘要翻译： 参与者之间由虚拟市场控制实体涵盖的交易的代理支付系统。 该系统确定每个虚拟市场控制实体参与者在给定日期所需的所有付款。 由于每个参与者由虚拟市场控制实体获得净现金流动，从虚拟市场控制实体到参与者的帐户，将虚拟市场控制实体收到的付款全部纳入参与者所需的付款， 从参与者账户到虚拟市场控制实体。 它在参与者的帐户和虚拟市场控制实体的帐户和每个参与者的账户之间转移到虚拟市场控制实体的账户的净现金流动。 然后，它在虚拟市场控制实体的账户和每个参与者的账户之间转移到参与者账户的净现金流动。

公开(公告)号：US20080015138A1

公开(公告)日：2008-01-17

申请号：US11776677

申请日：2007-07-12

申请人： Paul Hamilton ,  Wayne F. Beyer

发明人： Paul Hamilton ,  Wayne F. Beyer

IPC分类号： A61K38/00 ,  C07H19/04 ,  C07K2/00 ,  C07K4/00

CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K7/08 ,  Y10T428/31681

摘要： Compositions are provided comprising a family of peptides having binding specificity for metal, and their use to produce coating compositions. The coating compositions are used to deliver a pharmaceutically active agent to metal, and are used in methods related to metal implants, metal repair, and metal-related diseases.

摘要翻译： 提供了包含对金属具有结合特异性的肽家族及其用于生产涂料组合物的组合物。 涂料组合物用于将药物活性剂递送到金属中，并且用于与金属植入物，金属修复和金属相关疾病相关的方法。

公开(公告)号：US20060178974A1

公开(公告)日：2006-08-10

申请号：US11333789

申请日：2006-01-17

申请人： J. Perry ,  Wallace Turbeville ,  Paul Hamilton

发明人： J. Perry ,  Wallace Turbeville ,  Paul Hamilton

IPC分类号： G06Q40/00

CPC分类号： G06Q40/00 ,  G06Q40/04

摘要： An agency payment system for transactions covered by a virtual market control entity between participants. The system determines all payments required to be made by each virtual market control entity participant on a given day. It nets all of each of the participant's required payments to be made with the payments received by the virtual market control entity on the previous day due to each participant to obtain a net cash movement, either from the virtual market control entity to the participant's account or from the participant's account to the virtual market control entity. It transfers between the participant's account and the virtual market control entity's account and each participant's account the net cash movements to the virtual market control entity's account. It then transfers between the virtual market control entity's account and each participant's account the net cash movements to the participant's account.

摘要翻译： 参与者之间由虚拟市场控制实体涵盖的交易的代理支付系统。 该系统确定每个虚拟市场控制实体参与者在给定日期所需的所有付款。 由于每个参与者由虚拟市场控制实体获得净现金流动，从虚拟市场控制实体到参与者的帐户，将虚拟市场控制实体收到的付款全部纳入参与者所需的付款， 从参与者账户到虚拟市场控制实体。 它在参与者的帐户和虚拟市场控制实体的帐户和每个参与者的账户之间转移到虚拟市场控制实体的账户的净现金流动。 然后，它在虚拟市场控制实体的账户和每个参与者的账户之间转移到参与者账户的净现金流动。

公开(公告)号：US20050044034A1

公开(公告)日：2005-02-24

申请号：US10764126

申请日：2004-01-23

申请人： J. Perry ,  Wallace Turbeville ,  Paul Hamilton

发明人： J. Perry ,  Wallace Turbeville ,  Paul Hamilton

IPC分类号： G06F20060101 ,  G06Q40/00 ,  G06F17/60

CPC分类号： G06Q40/06 ,  G06Q20/102 ,  G06Q40/02 ,  G06Q40/04

摘要： A paired basis swap risk and credit mitigation system and collateral minimization system. In swaps used to hedge forward contracts a system authority interposes itself and forms paired basis swaps with each of the paired swap participants and itself together with a Swaption to allow it to maintain a level book in the event of a default by any counterparty. In the event of a default the system authority has the ability to either terminate a swap and pay the non-defaulting counterparty an agreed upon termination payment, terminate the non-defaulting counterparty's swap and exercise the swaption to substitute a correlated swap with appropriate correlated termination payment; or substitute a new counterparty with an identical swap as the paired swap participant. Paired basis swap control through delivery can be enabled to continue the risk and credit mitigation benefits of the system.

摘要翻译： 配对的基础互换风险和信贷减免系统和抵押最小化系统。 在用于对冲远期合约的互换中，系统管理机构将其自身置换并与每个配对掉期参与者及其自身一起进行配对的基本互换以及交换，以允许其在任何交易对手违约的情况下维护一个级别的账簿。 在违约的情况下，系统管理机构有能力终止互换并向未违约交易对手方支付约定的终止支付，终止非违约交易对手的掉期，并行使交换以适当的相关终止替代相关掉期 付款; 或用与配对互换参与者相同的交换替代新交易对手。 可以通过交付配对的基础互换控制来继续系统的风险和信贷减免优势。

公开(公告)号：US5092228A

公开(公告)日：1992-03-03

申请号：US608412

申请日：1990-11-02

申请人： Edward A. Pfeiffer, Jr. ,  Paul Hamilton

发明人： Edward A. Pfeiffer, Jr. ,  Paul Hamilton

IPC分类号： B08B15/00

CPC分类号： B08B15/00

摘要： An exhaust distribution system for a building to automatically attach/detach to a vertical exhaust stack of a vehicle located within the building. The system includes an elongate track for guiding movement of a trolley therealong from a first position adjacent the entrance of the building to a second remote position at which the vehicle is to be parked. The trolley supports one end, e.g., a mouth, of a flexible hose and includes a guiding device to orient the hose's mouth with respect to the exhaust stack to receive the exhaust fumes therefrom. An assembly automatically biases the trolley to the first position on the track. The system also includes a blower, a pressure responsive sensor, and a solenoid controlled damper to automatically vent the exhaust fumes out of the building whenever the pressure in the hose exceeds a predetermined level, e.g., a pressure level which would exist if the vehicle's motor was running.

摘要翻译： 一种用于建筑物的排气分配系统，其自动地附接/拆卸到位于建筑物内的车辆的垂直排气叠层。 该系统包括细长轨道，用于将邻近建筑物入口的第一位置的手推车的运动引导到待停放车辆的第二远程位置。 手推车支撑柔性软管的一端（例如嘴），并且包括引导装置，用于相对于排气叠层定位软管的口，以从其中接收废气。 组件自动将手推车偏置到轨道上的第一位置。 该系统还包括鼓风机，压力响应传感器和电磁控制的阻尼器，以便当软管中的压力超过预定水平时，例如，如果车辆的电动机 正在运行。