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    Synthetic compounds which bind to H. pylori, and uses thereof
    43.
    发明授权
    Synthetic compounds which bind to H. pylori, and uses thereof 失效
    与幽门螺杆菌结合的合成化合物及其用途

    公开(公告)号：US5543505A

    公开(公告)日：1996-08-06

    申请号：US213053

    申请日：1993-03-15

    申请人： Samuel J. Danishefsky ,  John T. Randolph

    发明人： Samuel J. Danishefsky ,  John T. Randolph

    IPC分类号： A61K38/00 ,  C07H3/06 ,  C07H17/04 ,  C07K9/00 ,  C07K14/765 ,  C07H15/00 ,  C07H15/06 ,  C07H17/00 ,  C07K1/00

    CPC分类号： C07K14/765 ,  C07H17/04 ,  C07H3/06 ,  C07K9/00 ,  A61K38/00

    摘要： The present invention provides a compound having the structure: ##STR1## wherein A is selected from the group consisting of (i) an amino acid bearing an .omega.-amino group or an .omega.--(C.dbd.O)-- group, (ii) an amino acid residue of a peptide, which residue bears an .omega.-amino group or an .omega.-(C.dbd.O)-- group, and (iii) an amino acid residue of a protein, which residue bears an .omega.-amino group or an .omega.-(C.dbd.O)-- group; wherein R.sub.1 is H, OH, NH.sub.2 or NHR.sub.4, where R.sub.4 is SO.sub.2 Ph, a linear or branched chain alkyl or acyl group, or an aryl group; wherein M is a saccharide wherein n is an integer from 0 to 18, and where n is greater than 1, each M is independently the same or different; wherein p is either 0 or 1; wherein R.sub.2, R.sub.3, R.sub.5 and R.sub.6 are independently the same or different and are H or OH, with the proviso that R.sub.2 and R.sub.3 are not both OH, and R.sub.5 and R.sub.6 are not both OH; wherein X and Y are independently the same or different and are H.sub.2 or O; and wherein k is an integer greater than or equal to 1, with the proviso that when A is an amino acid bearing an .omega.-amino group or an .omega.-(C.dbd.O)-- group, k is equal to 1.

    摘要翻译： 本发明提供具有以下结构的化合物：其中A选自（i）具有ω-氨基或ω-（C = O） - 基团的氨基酸 ，（ii）肽的氨基酸残基，该残基具有ω-氨基或ω-（C = O） - 基团，和（iii）蛋白质的氨基酸残基，该残基具有ω- 氨基或ω-（C = O） - 基团; 其中R 1是H，OH，NH 2或NHR 4，其中R 4是SO 2 Ph，直链或支链烷基或酰基或芳基; 其中M是糖，其中n是0至18的整数，并且其中n大于1，每个M独立地相同或不同; 其中p是0或1; 其中R2，R3，R5和R6独立地相同或不同，为H或OH，条件是R2和R3不同时为OH，R5和R6不同时为OH; 其中X和Y独立地相同或不同，为H 2或O; 并且其中k是大于或等于1的整数，条件是当A是具有ω-氨基或ω-（C = O） - 基团的氨基酸时，k等于1。