公开(公告)号：US08951964B2

公开(公告)日：2015-02-10

申请号：US13339448

申请日：2011-12-29

Applicant: Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  David J. Grampovnik ,  Brian Green ,  Timothy Middleton ,  Todd Hopkins ,  Yat Sun Or

Inventor： Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  David J. Grampovnik ,  Brian Green ,  Timothy Middleton ,  Todd Hopkins ,  Yat Sun Or

IPC: A61K38/00 ,  A01N37/18 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

Abstract translation: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。

公开(公告)号：US20130023463A1

公开(公告)日：2013-01-24

申请号：US13451370

申请日：2012-04-19

Applicant: Charles A. Flentge ,  Hui-Ju Chen ,  David A. DeGoey ,  William J. Flosi ,  David J. Grampovnik ,  Peggy P. Huang ,  Dale J. Kempf ,  Larry L. Klein ,  Allan C. Krueger ,  Darold L. Madigan ,  John T. Randolph ,  Minghua Sun ,  Ming C. Yeung ,  Chen Zhao

Inventor： Charles A. Flentge ,  Hui-Ju Chen ,  David A. DeGoey ,  William J. Flosi ,  David J. Grampovnik ,  Peggy P. Huang ,  Dale J. Kempf ,  Larry L. Klein ,  Allan C. Krueger ,  Darold L. Madigan ,  John T. Randolph ,  Minghua Sun ,  Ming C. Yeung ,  Chen Zhao

IPC: A61K31/18 ,  C07D213/53 ,  A61K31/4402 ,  C07D307/14 ,  A61K31/341 ,  A61K31/4418 ,  C07D307/52 ,  C07D277/30 ,  A61K31/426 ,  C07C275/24 ,  A61K31/197 ,  C07D213/86 ,  C07D493/04 ,  A61K31/34 ,  C07D333/20 ,  A61K31/381 ,  C07C275/16 ,  A61P31/18 ,  A61K31/513 ,  A61K31/496 ,  A61K31/7072 ,  A61K31/708 ,  A61K38/16 ,  C12N9/99 ,  C07C311/37

CPC classification number: C07D417/12 ,  C07C311/18 ,  C07C311/29 ,  C07C311/41 ,  C07C311/47 ,  C07C317/18 ,  C07D209/14 ,  C07D213/30 ,  C07D213/40 ,  C07D233/36 ,  C07D233/64 ,  C07D233/72 ,  C07D277/24 ,  C07D277/28 ,  C07D307/14 ,  C07D307/20 ,  C07D307/52 ,  C07D333/20 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/10 ,  C07D409/06 ,  C07D409/10 ,  C07D417/06 ,  C07D417/10 ,  C07D471/04 ,  C07D493/04

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。

公开(公告)号：US20120309762A1

公开(公告)日：2012-12-06

申请号：US13587516

申请日：2012-08-16

Applicant: Larry L. Klein ,  Hui-Ju Chen ,  Ming C. Yeung ,  Charles A. Flentge ,  John T. Randolph ,  Peggy P. Huang ,  Douglas K. Hutchinson ,  Dale J. Kempf

Inventor： Larry L. Klein ,  Hui-Ju Chen ,  Ming C. Yeung ,  Charles A. Flentge ,  John T. Randolph ,  Peggy P. Huang ,  Douglas K. Hutchinson ,  Dale J. Kempf

IPC: C07D277/24 ,  C07D417/12 ,  A61K31/4439 ,  A61K31/426 ,  A61K31/427 ,  A61P31/12 ,  C07D417/14 ,  A61K31/5355 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/454 ,  C12N9/99 ,  A61K31/513

CPC classification number: A61K31/5377 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  C07D213/79 ,  C07D277/24 ,  C07D277/30 ,  C07D277/593 ,  C07D417/12

Abstract: The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.

公开(公告)号：US20080161246A1

公开(公告)日：2008-07-03

申请号：US11846600

申请日：2007-08-29

Applicant: Larry L. Klein ,  Hui-Ju Chen ,  Ming C. Yeung ,  Charles A. Flentge ,  John T. Randolph ,  Peggy P. Huang ,  Douglas K. Hutchinson ,  Dale J. Kempf

Inventor： Larry L. Klein ,  Hui-Ju Chen ,  Ming C. Yeung ,  Charles A. Flentge ,  John T. Randolph ,  Peggy P. Huang ,  Douglas K. Hutchinson ,  Dale J. Kempf

IPC: A61K38/08 ,  C07K7/06 ,  A61P31/12

CPC classification number: A61K31/5377 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  C07D213/79 ,  C07D277/24 ,  C07D277/30 ,  C07D277/593 ,  C07D417/12

Abstract: The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.

Abstract translation: 本发明的特征在于式I化合物或其药学上可接受的盐，溶剂合物或前药，以及使用该化合物抑制CYP酶代谢活性的方法。 本发明还涉及使用这些化合物，盐，溶剂合物或前药来改善由CYP酶代谢的药物的药代动力学的方法。

公开(公告)号：US07042565B2

公开(公告)日：2006-05-09

申请号：US10777720

申请日：2004-02-13

Applicant: Jiann-Hua Wang ,  Hui Ju Chen ,  Tzu-Chiang Wu ,  Chien-Ho Chuang ,  Tsung-Kai Chuang

Inventor： Jiann-Hua Wang ,  Hui Ju Chen ,  Tzu-Chiang Wu ,  Chien-Ho Chuang ,  Tsung-Kai Chuang

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N2021/6417

Abstract: A fluorescent microarray analyzer includes a light source for emitting a light beam, a light processing unit for focusing the light beam on the biochip and exciting fluorescent targets on the biochip to produce fluorescence, a focusing lens for focusing the fluorescence on a spectrophotometer, a spectrophotometer for detecting signal of the fluorescence, and an output device for selectively outputting/displaying the signal detected by the spectrophotometer. The resulting signal of the output device does not need to be converted into image data for analysis. For acquiring a more accurate result of detection of signal of fluorescence from the fluorescent targets, the photomultiplier tube of the conventional biochip scanner device is replaced with the spectrophotometer of fluorescent microarray analyzer of the present invention and the filter is removed. Without converting the signal into an image, no errors arise as what happened in process of converting an electrical signal into image data in the conventional biochip. Also, a real-time analysis of the signal proceeds while scanning samples on the biochip.

Abstract translation: 荧光微阵列分析仪包括用于发射光束的光源，用于将光束聚焦在生物芯片上并激发生物芯片上的荧光靶产生荧光的光处理单元，用于将荧光聚焦在分光光度计上的聚焦透镜，分光光度计 用于检测荧光信号;以及输出装置，用于选择性地输出/显示由分光光度计检测的信号。 输出装置的结果信号不需要转换为图像数据进行分析。 为了从荧光靶获得更准确的荧光信号结果，用本发明的荧光微阵列分析仪的分光光度计代替常规生物芯片扫描器装置的光电倍增管，并除去滤光片。 在不将信号转换为图像的情况下，在传统生物芯片中将电信号转换为图像数据的过程中没有发生错误。 此外，在生物芯片上扫描样品时，信号的实时分析进行。

公开(公告)号：US06831096B2

公开(公告)日：2004-12-14

申请号：US10253152

申请日：2002-09-24

Applicant: Clarence J. Maring ,  Yu Gui Gu ,  Hui-Ju Chen ,  Yuanwei Chen ,  David A. Degoey ,  William J. Flosi ,  Vincent L. Giranda ,  David J. Grampovnik ,  Warren M. Kati ,  Dale J. Kempf ,  April Kennedy ,  Larry L. Klein ,  Allan C. Krueger ,  Zhen Lin ,  Darold L. Madigan ,  Keith F. McDaniel ,  Steven W. Muchmore ,  Hing L. Sham ,  Kent D. Stewart ,  Vincent S. Stoll ,  Minghua Sun ,  Noah P. Tu ,  Frank L. Wagenaar ,  Gary T. Wang ,  Sheldon Wang ,  Paul E. Wiedeman ,  Yibo Xu ,  Ming C. Yeung ,  Chen Zhao ,  Stephen Hanessian ,  Malken Bayrakdarian ,  Xuehong Luo

Inventor： Clarence J. Maring ,  Yu Gui Gu ,  Hui-Ju Chen ,  Yuanwei Chen ,  David A. Degoey ,  William J. Flosi ,  Vincent L. Giranda ,  David J. Grampovnik ,  Warren M. Kati ,  Dale J. Kempf ,  April Kennedy ,  Larry L. Klein ,  Allan C. Krueger ,  Zhen Lin ,  Darold L. Madigan ,  Keith F. McDaniel ,  Steven W. Muchmore ,  Hing L. Sham ,  Kent D. Stewart ,  Vincent S. Stoll ,  Minghua Sun ,  Noah P. Tu ,  Frank L. Wagenaar ,  Gary T. Wang ,  Sheldon Wang ,  Paul E. Wiedeman ,  Yibo Xu ,  Ming C. Yeung ,  Chen Zhao ,  Stephen Hanessian ,  Malken Bayrakdarian ,  Xuehong Luo

IPC: A61K3140

CPC classification number: C07D207/16 ,  C07D207/26 ,  C07D207/327 ,  C07D207/38 ,  C07D207/46 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D303/16 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/04 ,  C07D417/04 ,  C07D417/06

Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

Abstract translation: 公开了下式的化合物：其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。

公开(公告)号：US6016263A

公开(公告)日：2000-01-18

申请号：US333982

申请日：1999-06-16

Applicant: Hui-Ju Chen

Inventor： Hui-Ju Chen

IPC: G06F9/318 ,  G06F9/445 ,  H01L27/108

CPC classification number: G06F9/3017 ,  G06F9/4401

Abstract: A storage device is designed for use with a personal computer system and formed of a RAM module connected with a power unit, and a memory accessing unit which is intended to access data in the RAM module and is connected with a data accessing interface serving as a data accessing interface between the storage device and the personal computer system. The memory accessing unit and the data accessing interface are connected with a command translating unit which is intended to translate a control machine code of the hard disk of the personal computer system into a control machine code of the memory accessing unit. The booting of the personal computer system and the executing of application programs by the personal computer system are accelerated by the storage device.

Abstract translation: 存储装置被设计为与个人计算机系统一起使用并且由与功率单元连接的RAM模块形成，以及存储器访问单元，其用于访问RAM模块中的数据，并且与用作数据访问接口的数据访问接口连接 存储设备和个人计算机系统之间的数据访问接口。 存储器访问单元和数据访问接口与用于将个人计算机系统的硬盘的控制机器代码转换为存储器访问单元的控制机器代码的命令转换单元连接。 由个人计算机系统启动个人计算机系统和执行应用程序由存储装置加速。

公开(公告)号：US08653141B2

公开(公告)日：2014-02-18

申请号：US13451370

申请日：2012-04-19

Applicant: Charles A. Flentge ,  Hui-Ju Chen ,  David A. DeGoey ,  William J. Flosi ,  David J. Grampovnik ,  Peggy P. Huang ,  Dale J. Kempf ,  Larry L. Klein ,  Allan C. Krueger ,  Darold L. Madigan ,  John T. Randolph ,  Minghua Sun ,  Ming C. Yeung ,  Chen Zhao

Inventor： Charles A. Flentge ,  Hui-Ju Chen ,  David A. DeGoey ,  William J. Flosi ,  David J. Grampovnik ,  Peggy P. Huang ,  Dale J. Kempf ,  Larry L. Klein ,  Allan C. Krueger ,  Darold L. Madigan ,  John T. Randolph ,  Minghua Sun ,  Ming C. Yeung ,  Chen Zhao

IPC: A61K31/18 ,  C07D307/00

CPC classification number: C07D417/12 ,  C07C311/18 ,  C07C311/29 ,  C07C311/41 ,  C07C311/47 ,  C07C317/18 ,  C07D209/14 ,  C07D213/30 ,  C07D213/40 ,  C07D233/36 ,  C07D233/64 ,  C07D233/72 ,  C07D277/24 ,  C07D277/28 ,  C07D307/14 ,  C07D307/20 ,  C07D307/52 ,  C07D333/20 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/10 ,  C07D409/06 ,  C07D409/10 ,  C07D417/06 ,  C07D417/10 ,  C07D471/04 ,  C07D493/04

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。

公开(公告)号：US20050159469A1

公开(公告)日：2005-07-21

申请号：US11010177

申请日：2004-12-10

Applicant: John Randolph ,  Hui-Ju Chen ,  David DeGoey ,  Charles Flentge ,  William Flosi ,  David Grampovnik ,  Peggy Huang ,  Douglas Hutchinson ,  Dale Kempf ,  Larry Klein ,  Ming Yeung

Inventor： John Randolph ,  Hui-Ju Chen ,  David DeGoey ,  Charles Flentge ,  William Flosi ,  David Grampovnik ,  Peggy Huang ,  Douglas Hutchinson ,  Dale Kempf ,  Larry Klein ,  Ming Yeung

IPC: A61K31/4166 ,  A61K31/4178 ,  C07C243/24 ,  C07C271/22 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D43/02

CPC classification number: C07C271/22 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

公开(公告)号：US08642538B2

公开(公告)日：2014-02-04

申请号：US13439551

申请日：2012-04-04

Applicant: Yiyin Ku ,  Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  Dale J. Kempf ,  David J. Grampovnik

Inventor： Yiyin Ku ,  Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  Dale J. Kempf ,  David J. Grampovnik

IPC: A61K38/00 ,  A01N37/18

CPC classification number: C07K1/113 ,  C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.