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公开(公告)号：US07579363B2
公开(公告)日：2009-08-25
申请号：US11769679
申请日：2007-06-27
申请人： Valentina Molteni , Xiaohui He , Yun He , Andreas Kreusch , Juliet Nabakka , Kunyong Yang
发明人： Valentina Molteni , Xiaohui He , Yun He , Andreas Kreusch , Juliet Nabakka , Kunyong Yang
IPC分类号： C07D417/12 , C07D279/16 , A61K31/5415
CPC分类号： C07D279/16 , C07D215/227 , C07D417/06 , C07D417/12
摘要： This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions comprising these compounds.
摘要翻译： 本发明涉及新颖的双环化合物，涉及这些化合物在各种医学应用中的用途，包括治疗适合于通过肽基变性酶抑制剂治疗的疾病，例如治疗细菌感染，以及包含这些化合物的药物组合物。
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公开(公告)号：US20070259852A1
公开(公告)日：2007-11-08
申请号：US11769679
申请日：2007-06-27
申请人： Valentina Molteni , Xiaohui He , Yun He , Andreas Kreusch , Juliet Nabakka , Kunyong Yang
发明人： Valentina Molteni , Xiaohui He , Yun He , Andreas Kreusch , Juliet Nabakka , Kunyong Yang
IPC分类号： A61K31/47 , A61K31/54 , A61K31/55 , C07D215/02 , C07D279/10 , C07D417/00 , C07D487/00
CPC分类号： C07D279/16 , C07D215/227 , C07D417/06 , C07D417/12
摘要： This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions comprising these compounds.
摘要翻译： 本发明涉及新颖的双环化合物，涉及这些化合物在各种药物应用中的用途，包括治疗适合于通过肽基变性酶抑制剂治疗的疾病，例如治疗细菌感染，以及包含这些化合物的药物组合物。
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公开(公告)号：US07253164B2
公开(公告)日：2007-08-07
申请号：US10903349
申请日：2004-07-30
申请人： Valentina Molteni , Xiaohui He , Yun He , Andreas Kreusch , Juliet Nabakka , Kunyong Yang
发明人： Valentina Molteni , Xiaohui He , Yun He , Andreas Kreusch , Juliet Nabakka , Kunyong Yang
IPC分类号： C07D417/12 , C07D279/16 , A61K31/5415
CPC分类号： C07D279/16 , C07D215/227 , C07D417/06 , C07D417/12
摘要： This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions comprising these compounds.
摘要翻译： 本发明涉及新颖的双环化合物，涉及这些化合物在各种药物应用中的用途，包括治疗适合于通过肽基变性酶抑制剂治疗的疾病，例如治疗细菌感染，以及包含这些化合物的药物组合物。
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公开(公告)号：US20050197326A1
公开(公告)日：2005-09-08
申请号：US10903349
申请日：2004-07-30
申请人： Valentina Molteni , Xiaohui He , Yun He , Andreas Kreusch , Juliet Nabakka , Kunyong Yang
发明人： Valentina Molteni , Xiaohui He , Yun He , Andreas Kreusch , Juliet Nabakka , Kunyong Yang
IPC分类号： A61K20060101 , A61K31/438 , A61K31/4706 , A61K31/4985 , A61K31/5415 , A61K31/55 , C07D211/00 , C07D279/00 , C07D401/00 , C07D417/00
CPC分类号： C07D279/16 , C07D215/227 , C07D417/06 , C07D417/12
摘要： This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions comprising these compounds.
摘要翻译： 本发明涉及新颖的双环化合物，涉及这些化合物在各种药物应用中的用途，包括治疗适合于通过肽基变性酶抑制剂治疗的疾病，例如治疗细菌感染，以及包含这些化合物的药物组合物。
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公开(公告)号：US20130331397A1
公开(公告)日：2013-12-12
申请号：US14000578
申请日：2012-02-23
申请人： Valentina Molteni , Yi Fan , Jon Loren , Jeffrey M. Smith , Brenton T. Flatt
发明人： Valentina Molteni , Yi Fan , Jon Loren , Jeffrey M. Smith , Brenton T. Flatt
IPC分类号： C07D471/04 , C07D207/09
CPC分类号： C07D471/04 , C07D207/09
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity. wherein: A is X1 is CH or N;
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TRK激酶活性相关的疾病或病症的方法。 其中：A是X 1是CH或N;
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公开(公告)号：US20120065184A1
公开(公告)日：2012-03-15
申请号：US13227957
申请日：2011-09-08
申请人： Yi Fan , Jon Loren , Valentina Molteni , Pamela A. Albaugh , Gregory Chopiuk , Jeffrey M. Smith , Brenton T. Flatt
发明人： Yi Fan , Jon Loren , Valentina Molteni , Pamela A. Albaugh , Gregory Chopiuk , Jeffrey M. Smith , Brenton T. Flatt
IPC分类号： A61K31/5025 , A61K31/5377 , A61P11/06 , A61P25/00 , A61P17/00 , C07D487/04 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TRK激酶活性相关的疾病或病症的方法。
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公开(公告)号：US09102671B2
公开(公告)日：2015-08-11
申请号：US14000578
申请日：2012-02-23
申请人： Valentina Molteni , Yi Fan , Jon Loren , Jeffrey M. Smith , Brenton T. Flatt
发明人： Valentina Molteni , Yi Fan , Jon Loren , Jeffrey M. Smith , Brenton T. Flatt
IPC分类号： A61K31/497 , C07D471/04 , C07D207/09
CPC分类号： C07D471/04 , C07D207/09
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity. wherein: A is X1 is CH or N;
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TRK激酶活性相关的疾病或病症的方法。 其中：A是X 1是CH或N;
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公开(公告)号：US08637516B2
公开(公告)日：2014-01-28
申请号：US13227957
申请日：2011-09-08
申请人： Yi Fan , Jon Loren , Valentina Molteni , Pamela A. Albaugh , Gregory Chopiuk , Jeffrey M. Smith , Brenton T. Flatt
发明人： Yi Fan , Jon Loren , Valentina Molteni , Pamela A. Albaugh , Gregory Chopiuk , Jeffrey M. Smith , Brenton T. Flatt
IPC分类号： A01N43/58 , A61K31/50 , C07D487/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TRK激酶活性相关的疾病或病症的方法。
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公开(公告)号：US09303034B2
公开(公告)日：2016-04-05
申请号：US14574775
申请日：2014-12-18
申请人： Agnes Biggart , Fang Liang , Casey Jacob Nelson Mathison , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Vince Yeh
发明人： Agnes Biggart , Fang Liang , Casey Jacob Nelson Mathison , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Vince Yeh
IPC分类号： A61K31/519 , C07D487/04 , C07D519/00 , C07F5/02 , C07F7/08
CPC分类号： A61K31/519 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D487/04 , C07D519/00 , C07F5/027 , C07F7/0814
摘要： The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.
摘要翻译： 本发明提供式A化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供了包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯 疾病。
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公开(公告)号：US09233961B2
公开(公告)日：2016-01-12
申请号：US14209536
申请日：2014-03-13
申请人： Arnab Kumar Chatterjee , Fang Liang , Casey Jacob Nelson Mathison , Pranab Kumar Mishra , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Liying Jocelyn Tan , Agnes Vidal , Michael Herman Gelb , Frederick Simmons Buckner , Hari Babu Tatipaka , Neil Richard Norcross , John Robert Gillespie
发明人： Arnab Kumar Chatterjee , Fang Liang , Casey Jacob Nelson Mathison , Pranab Kumar Mishra , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Liying Jocelyn Tan , Agnes Vidal , Michael Herman Gelb , Frederick Simmons Buckner , Hari Babu Tatipaka , Neil Richard Norcross , John Robert Gillespie
IPC分类号： C07D471/02 , A61K31/50 , A61K31/415 , C07D473/00 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D473/00 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.
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