公开(公告)号：US08128614B2

公开(公告)日：2012-03-06

申请号：US12353112

申请日：2009-01-13

申请人： Robert M. Abrams ,  Michael P. Wallace

发明人： Robert M. Abrams ,  Michael P. Wallace

IPC分类号： A61M25/01

CPC分类号： A61M25/0662 ,  A61M25/10 ,  A61M2025/0006 ,  A61M2025/0293 ,  A61M2025/0681 ,  A61M2025/09125 ,  A61M2025/1063

摘要： An apparatus for accessing a site within a body includes a cannula and an elongate member. The cannula has a proximal end, a distal end, and a lumen extending therebetween. The elongate member has a distal end configured for insertion into the lumen, wherein the distal end of the elongate member is attachable to and releasable from the distal end of the cannula. A method for accessing a site within a body includes inserting a distal end of an elongate member into a lumen of a cannula, detachably attaching the distal end of the elongate member to the cannula, and steering a distal end of the cannula to a desired site using the elongate member.

摘要翻译： 用于进入体内部位的装置包括套管和细长构件。 套管具有近端，远端和在其间延伸的内腔。 细长构件具有构造成用于插入内腔的远端，其中细长构件的远端可附接到插管的远端并且可从插管的远端释放。 用于访问体内部位的方法包括将细长构件的远端插入套管的内腔，将细长构件的远端可拆卸地连接到套管上，并将套管的远端转向所需位置 使用细长构件。

公开(公告)号：US08060207B2

公开(公告)日：2011-11-15

申请号：US10744853

申请日：2003-12-22

申请人： Michael P. Wallace ,  Kamal Ramzipoor ,  Robert J. Garabedian ,  Robert M. Abrams

发明人： Michael P. Wallace ,  Kamal Ramzipoor ,  Robert J. Garabedian ,  Robert M. Abrams

IPC分类号： A61N1/00

CPC分类号： A61N1/0529 ,  A61N1/0531 ,  A61N1/0534

摘要： A method of treating a disorder in a patient is provided. The method comprises delivering a stimulation lead within a blood vessel, intralumenally puncturing a wall of the blood vessel to create an exit point, and then introducing the stimulation lead through the exit point into direct contact with tissue the stimulation of which treats the disorder. Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead to the implanted stimulation source. Using the stimulation lead, the tissue can then be stimulated in order to treat the disorder.

摘要翻译： 提供了一种治疗患者疾病的方法。 该方法包括在血管内递送刺激引线，腔内穿刺血管的壁以产生出口点，然后将刺激引线通过出口点直接接触组织，其刺激治疗病症。 可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电耦合到植入的刺激源。 使用刺激铅，然后可以刺激组织以治疗该疾病。

公开(公告)号：US20110237982A1

公开(公告)日：2011-09-29

申请号：US13134470

申请日：2011-06-08

申请人： Michael P. Wallace

发明人： Michael P. Wallace

IPC分类号： A61N7/00

CPC分类号： A61B17/22012 ,  A61B17/2202 ,  A61B2017/22014 ,  A61B2017/22082 ,  A61B2017/22088 ,  A61B2018/00029

摘要： Apparatus and methods are disclosed for vein and arterial-venous fistulas stenosis and occlusion therapies, including enhancing permeability of the vessel wall using ultrasound energy and delivering a therapeutic agent into the vessel wall. Ultrasound energy may be delivered at frequencies less than 10 MHz and power less than 20 watts using transcutaneous techniques and endovascular methods. Therapeutic agents may be delivered to the treatment area via intravenous and endovascular methods. In some embodiments, ultrasound energy and therapeutic agent application may be combined with angioplasty techniques and with blood flow protection devices. In some other embodiments, a therapeutic agent may be removed from the body after exposure to the vessel wall to minimize a systemic effect of the therapeutic drug.

摘要翻译： 公开了用于静脉和动脉 - 静脉瘘狭窄和闭塞治疗的装置和方法，包括使用超声能量增强血管壁的渗透性并将治疗剂递送到血管壁中。 超声能量可以使用经皮技术和血管内方法在小于10MHz的频率和功率小于20瓦的情况下递送。 治疗剂可通过静脉内和血管内途径递送至治疗区域。 在一些实施例中，超声能量和治疗剂应用可以与血管成形术技术和血液流动保护装置组合。 在一些其它实施方案中，治疗剂可以在暴露于血管壁之后从体内除去，以使治疗药物的全身效应最小化。

公开(公告)号：US08019441B2

公开(公告)日：2011-09-13

申请号：US11459618

申请日：2006-07-24

申请人： Michael P. Wallace ,  Robert J. Garabedian

发明人： Michael P. Wallace ,  Robert J. Garabedian

IPC分类号： A61N1/05

CPC分类号： A61N1/0553

摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative tubular membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force. In one preferred method, the stimulation lead is used to stimulate tissue, such as spinal cord tissue.

摘要翻译： 提供医疗用铅和治疗患者的方法。 医用引线包括电绝缘管状膜，与绝缘膜相关联的弹性弹簧元件以及与绝缘膜相关联的至少一个电极。 医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。 由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。 可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态 压缩力。 在一种优选的方法中，刺激引线用于刺激组织，例如脊髓组织。

公开(公告)号：US20110118768A1

公开(公告)日：2011-05-19

申请号：US13013044

申请日：2011-01-25

申请人： Tri Tran ,  Kim Nguyen ,  Hanh Ho ,  My Doan ,  Richard Murphy ,  Michael P. Wallace ,  Clifford Teoh

发明人： Tri Tran ,  Kim Nguyen ,  Hanh Ho ,  My Doan ,  Richard Murphy ,  Michael P. Wallace ,  Clifford Teoh

IPC分类号： A61B17/00

CPC分类号： A61B17/12113 ,  A61B17/12022 ,  A61B17/12172 ,  A61B17/12186 ,  A61B17/1219 ,  A61B2017/1205 ,  A61B2017/12063

摘要： Methods and devices for blocking orifices and occluding cavities within a patient are provided. The device in one variation comprises first and second tubular members attached to a collapsible sealing element. The device can be placed through an orifice and the collapsible sealing element can be collapsed to seal the orifice. An embolic may be introduced distal to the sealing element to occlude a cavity. The device may incorporate a locking mechanism which can be engaged to lock the sealing element into the collapsed position. The device may incorporate a valve to prevent flow through the tubular members, for example to prevent egress of the embolic from a cavity. The device can be detached to provide a permanent seal of the orifice, and can retain the embolic within the cavity. The device may be used in conjunction with a stent or other retention device to assist the sealing element in maintaining the seal.

摘要翻译： 提供了用于阻断患者内的孔和闭塞腔的方法和装置。 一个变型中的装置包括附接到可折叠密封元件的第一和第二管状构件。 该装置可以通过孔口放置，并且可折叠密封元件可以折叠以密封孔口。 可以在密封元件的远侧引入栓塞以封闭空腔。 该装置可以包括可以接合以将密封元件锁定到折叠位置的锁定机构。 该装置可以包括阀以防止流过管状构件，例如以防止栓塞从空腔排出。 该装置可以被拆卸以提供孔口的永久性密封，并且可以将栓塞保持在空腔内。 该装置可以与支架或其它保持装置结合使用以帮助密封元件保持密封。

公开(公告)号：US20110082414A1

公开(公告)日：2011-04-07

申请号：US12661853

申请日：2010-03-25

申请人： Michael P. Wallace

发明人： Michael P. Wallace

IPC分类号： A61N7/00 ,  A61M25/00

CPC分类号： A61M37/0092 ,  A61B17/22004 ,  A61M25/104 ,  A61N2007/0043

摘要： Apparatus and methods for enhancing vascular stenosis therapy involve applying ultrasound energy to delivery of a therapeutic agent to enhance vessel wall penetration of the agent in an area of stenosis. In some embodiments, ultrasound energy and therapeutic agent application may be combined with angioplasty techniques and/or with blood flow protection devices to prevent dissipation of the therapeutic agent from the treatment site.

摘要翻译： 用于增强血管狭窄治疗的装置和方法包括将超声能量应用于递送治疗剂以增强药剂在狭窄区域中的渗透性。 在一些实施例中，超声能量和治疗剂应用可以与血管成形术技术和/或与血液流动保护装置组合以防止治疗剂从治疗部位的耗散。

公开(公告)号：US07758541B2

公开(公告)日：2010-07-20

申请号：US10920735

申请日：2004-08-17

申请人： Michael P. Wallace ,  Robert J. Garabedian

发明人： Michael P. Wallace ,  Robert J. Garabedian

IPC分类号： A61M31/00

CPC分类号： A61M25/10 ,  A61M25/0141 ,  A61M25/0147 ,  A61M2025/0163 ,  A61M2025/105 ,  A61M2025/1086

摘要： A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting an region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.

摘要翻译： 提供了靶向药物递送装置。 该装置包括具有近端和远端的细长构件，与细长构件的远端相关联的多个输注端口以及用于选择性地将引导器端口与至少一个输注端口流体连通的选择器机构。 还提供了一种治疗组织的方法。 该方法包括将医疗装置引入组织中，选择组织的区域以治疗，将医疗装置定位在该区域附近，以及通过该装置引入药物以仅对该区域进行治疗。

公开(公告)号：US20090012518A1

公开(公告)日：2009-01-08

申请号：US12168042

申请日：2008-07-03

申请人： David S. Utley ,  Michael P. Wallace

发明人： David S. Utley ,  Michael P. Wallace

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B18/02 ,  A61B18/18 ,  A61B2018/0016 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00482 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/044 ,  A61B2018/1467 ,  A61B2018/1497 ,  A61B2090/064 ,  A61B2218/007

摘要： Devices and methods are provided for ablating areas of the gastrointestinal tract affected with certain benign, pre-cancerous, or early cancerous lesions that originate within the epithelium and are limited to the mucosal layer of the gastrointestinal tract wall. Examples of such lesions include benign conditions such as cervical inlet patch (ectopic gastric mucosa in the upper esophagus), as well as pre-cancerous and cancerous conditions such as intestinal metaplasia/intra-epithelial neoplasia/early cancer of the stomach, squamous intra-epithelial neoplasia and early cancer of the esophagus, oral and pharyngeal leukoplakia, flat colonic polyps, anal intra-epithelial neoplasia (AIN), and early cancers of the anal canal. Ablation, as provided the invention, commences at the epithelial layer of the gastrointestinal wall and penetrates deeper into the gastrointestinal wall in a controlled manner to achieve a successful patient outcome, the latter of which is defined generally as eradication of the targeted lesion, and/or a change in the targeted lesion to prevent or forestall patient morbidity. Embodiments of the device include an ablational electrode array that spans 360 degrees and an array that spans an arc of less than 360 degrees.

摘要翻译： 提供了装置和方法，用于消融受到某些良性，癌前或早期癌性病变影响的胃肠道区域，这些病变起源于上皮内，并限于胃肠道壁的粘膜层。 这种病变的实例包括诸如宫颈入口贴片（上食管中的异位胃粘膜）的良性病症，以及癌前和癌症状况如肠化生/上皮内瘤变/胃癌早期癌，鳞状内膜炎， 食道上皮性肿瘤和早期癌症，口腔和咽部白斑，扁平结肠息肉，肛门上皮内瘤变（AIN）和肛管早期癌症。 根据本发明，消融在胃肠壁的上皮层开始，并以受控的方式深入胃肠壁以实现成功的患者结果，后者通常定义为根除靶向病变，和/ 或改变目标病变以预防或预防患者发病。 该装置的实施例包括跨越360度的消融电极阵列和跨越小于360度的弧的阵列。

公开(公告)号：US07410482B2

公开(公告)日：2008-08-12

申请号：US10319379

申请日：2002-12-13

申请人： Richard Murphy ,  Michael P. Wallace ,  Tri Tran ,  Kim Nguyen ,  Hanh Ho ,  My Doan ,  Robert M. Abrams ,  Harold F. Carrison

发明人： Richard Murphy ,  Michael P. Wallace ,  Tri Tran ,  Kim Nguyen ,  Hanh Ho ,  My Doan ,  Robert M. Abrams ,  Harold F. Carrison

IPC分类号： A61B17/00

CPC分类号： A61B17/12113 ,  A61B17/12022 ,  A61B17/1214 ,  A61B17/12168 ,  A61B17/12172 ,  A61B90/39 ,  A61B2017/1205 ,  A61B2017/12063

摘要： In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.

摘要翻译： 在一个实施例中，用于桥接动脉瘤颈部的颈桥包括连接区域，连接到接合区域的多个径向延伸的阵列元件以及附接到接合区域和阵列元件中的一个或两者的盖。 阵列元件构造成在颈桥从输送装置部署之后定位在动脉瘤内。 在第二实施例中，颈桥包括固定到接合区域的连接区域和编织或网状结构。 编织或网状结构由弹性材料制成。

公开(公告)号：US06533801B2

公开(公告)日：2003-03-18

申请号：US09997276

申请日：2001-11-27

申请人： Michael P. Wallace ,  Chad C. Roue

发明人： Michael P. Wallace ,  Chad C. Roue

IPC分类号： A61M2900

CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12163 ,  A61B2017/1205 ,  A61B2017/12063

摘要： This device is an apparatus for endovascular occlusion through the formation of thrombi in arteries, veins, aneurysms, vascular malformations, and arteriovenous fistulas. In particular, the device includes multiple vaso-occlusive members connected by electrolytically disintegratible links. Each link connects to the vaso-occlusive member by electrically insulative and conductive joints on opposite ends of the link. The vaso-occlusive members are delivered through a delivery catheter having on its distal end an electrode for electrical contact with the vaso-occlusive member. Upon application of an electrical current through the electrode to the vaso-occlusive member and its conductive joint to the electrolytically disintegratible link, the link disintegrates, selectively detaching the desired number of vaso-occlusive members into the target thrombus formation site.