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1.发明授权Method of intravascularly delivering stimulation leads into direct contact with tissue 失效血管内传递刺激的方法导致与组织直接接触公开(公告)号：US08060207B2
公开(公告)日：2011-11-15
申请号：US10744853
申请日：2003-12-22
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a disorder in a patient is provided. The method comprises delivering a stimulation lead within a blood vessel, intralumenally puncturing a wall of the blood vessel to create an exit point, and then introducing the stimulation lead through the exit point into direct contact with tissue the stimulation of which treats the disorder. Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead to the implanted stimulation source. Using the stimulation lead, the tissue can then be stimulated in order to treat the disorder.
摘要翻译： 提供了一种治疗患者疾病的方法。 该方法包括在血管内递送刺激引线，腔内穿刺血管的壁以产生出口点，然后将刺激引线通过出口点直接接触组织，其刺激治疗病症。 可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电耦合到植入的刺激源。 使用刺激铅，然后可以刺激组织以治疗该疾病。
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2.发明授权Method of intravascularly delivering stimulation leads into brain to stimulate the SPG 有权血管内传递刺激的方法导致大脑刺激SPG公开(公告)号：US07818063B2
公开(公告)日：2010-10-19
申请号：US11627359
申请日：2007-01-25
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a neurological disorder in a patient is provided. The method comprises intravascularly delivering a stimulation lead within the head of the patient, and placing the stimulation lead adjacent brain tissue (e.g., cortical brain tissue or deep brain tissue), the stimulation of which will treat the neurological disorder. The stimulation lead can be placed into indirect contact with the brain tissue (e.g., through a blood vessel) or indirect contact with the brain tissue (e.g., when placed within the ventricular cavity or by being introduced through an exit point within a vessel wall). Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead, which conveniently extends from the access point within the circulatory system, to the implanted stimulation source. Using the stimulation lead, the brain tissue can then be stimulated in order to treat the neurological disorder.
摘要翻译： 提供了治疗患者神经障碍的方法。 该方法包括血管内递送患者头部内的刺激引线，并将刺激引导线邻近脑组织（例如皮质脑组织或深部脑组织）放置，其刺激将治疗神经障碍。 刺激引线可以与脑组织（例如，通过血管）间接接触或与脑组织间接接触（例如当放置在心室内或通过血管壁内的出口点引入时） 。 可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电连接，其方便地从循环系统内的接入点延伸到植入的刺激源。 使用刺激引线，可以刺激脑组织以治疗神经系统疾病。
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公开(公告)号：US07608089B2
公开(公告)日：2009-10-27
申请号：US11022189
申请日：2004-12-22
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B2017/00477 , A61B2017/12054 , A61B2017/12063 , A61B2017/12095
摘要： An assembly for occluding a vascular site (e.g., an aneurysm) of a human or veterinary patient includes a vaso-occlusive member, a pusher member having a distal end and a severable junction located proximal to the distal end, and a pivotable coupling that couples the pusher member to the occlusive member. A delivery catheter can be used to deliver the vaso-occlusive member to the vascular site. A method of using the assembly to occlude an aneurysm having an aneurysmal sac and an aneurysmal neck, includes locating the catheter within the aneurysmal neck, and manipulating the pusher member to place the vaso-occlusive member within the aneurysmal sac. The method further includes severing the severable junction to detach the vaso-occlusive member from the pusher member. As a result, an axial force is applied by the vaso-occlusive member in a proximal direction, which buckles the pivotable coupling to laterally deflect the axial force. The lateral deflection of the axial force caused by the buckling of the pivotable coupling prevents the catheter from being displaced from the aneurysmal neck by the axial force.
摘要翻译： 用于闭塞人或兽医患者的血管部位（例如，动脉瘤）的组件包括血管闭塞构件，具有远端的推动器构件和位于远端附近的可分离接合部以及可枢转联接件 推动器构件到闭塞构件。 输送导管可用于将血管闭塞成员递送至血管部位。 一种使用组件闭塞具有动脉瘤囊和动脉瘤颈部的动脉瘤的方法，包括将导管定位在动脉瘤颈内，以及操纵推动器构件以将血管闭塞构件置于动脉瘤囊内。 该方法还包括切断可分开的连接处以将血管闭塞构件与推动器构件分离。 结果，轴向力由近端方向由血管闭塞构件施加，该近侧方向使可枢转联接器弯曲以横向偏转轴向力。 由可枢转联轴器的弯曲引起的轴向力的横向偏转防止导管通过轴向力从动脉瘤颈部移位。
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公开(公告)号：US20100042133A1
公开(公告)日：2010-02-18
申请号：US12605175
申请日：2009-10-23
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B2017/00477 , A61B2017/12054 , A61B2017/12063 , A61B2017/12095
摘要： An assembly for occluding a vascular site (e.g., an aneurysm) of a human or veterinary patient includes a vaso-occlusive member, a pusher member having a distal end and a severable junction located proximal to the distal end, and a pivotable coupling that couples the pusher member to the occlusive member. A delivery catheter can be used to deliver the vaso-occlusive member to the vascular site. A method of using the assembly to occlude an aneurysm having an aneurysmal sac and an aneurysmal neck, includes locating the catheter within the aneurysmal neck, and manipulating the pusher member to place the vaso-occlusive member within the aneurysmal sac. The method further includes severing the severable junction to detach the vaso-occlusive member from the pusher member. As a result, an axial force is applied by the vaso-occlusive member in a proximal direction, which buckles the pivotable coupling to laterally deflect the axial force. The lateral deflection of the axial force caused by the buckling of the pivotable coupling prevents the catheter from being displaced from the aneurysmal neck by the axial force.
摘要翻译： 用于闭塞人或兽医患者的血管部位（例如，动脉瘤）的组件包括血管闭塞构件，具有远端的推动器构件和位于远端附近的可分离接合部以及可枢转联接件 推动器构件到闭塞构件。 输送导管可用于将血管闭塞成员递送至血管部位。 一种使用组件闭塞具有动脉瘤囊和动脉瘤颈部的动脉瘤的方法，包括将导管定位在动脉瘤颈内，以及操纵推动器构件以将血管闭塞构件置于动脉瘤囊内。 该方法还包括切断可分开的连接处以将血管闭塞构件与推动器构件分离。 结果，轴向力由近端方向由血管闭塞构件施加，该近侧方向使可枢转联接器弯曲以横向偏转轴向力。 由可枢转联轴器的弯曲引起的轴向力的横向偏转防止导管通过轴向力从动脉瘤颈部移位。
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公开(公告)号：US08206346B2
公开(公告)日：2012-06-26
申请号：US12838934
申请日：2010-07-19
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M25/0141 , A61M25/0147 , A61M2025/0163 , A61M2025/105 , A61M2025/1086
摘要： A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting a region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.
摘要翻译： 提供了靶向药物递送装置。 该装置包括具有近端和远端的细长构件，与细长构件的远端相关联的多个输注端口以及用于选择性地将引导器端口与至少一个输注端口流体连通的选择器机构。 还提供了一种治疗组织的方法。 该方法包括将医疗装置引入组织中，选择组织的区域以治疗，将医疗装置定位在该区域附近，以及通过该装置引入药物以仅治疗该区域。
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公开(公告)号：US08019441B2
公开(公告)日：2011-09-13
申请号：US11459618
申请日：2006-07-24
IPC分类号： A61N1/05
CPC分类号： A61N1/0553
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative tubular membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force. In one preferred method, the stimulation lead is used to stimulate tissue, such as spinal cord tissue.
摘要翻译： 提供医疗用铅和治疗患者的方法。 医用引线包括电绝缘管状膜，与绝缘膜相关联的弹性弹簧元件以及与绝缘膜相关联的至少一个电极。 医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。 由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。 可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态 压缩力。 在一种优选的方法中，刺激引线用于刺激组织，例如脊髓组织。
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公开(公告)号：US07758541B2
公开(公告)日：2010-07-20
申请号：US10920735
申请日：2004-08-17
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M25/0141 , A61M25/0147 , A61M2025/0163 , A61M2025/105 , A61M2025/1086
摘要： A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting an region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.
摘要翻译： 提供了靶向药物递送装置。 该装置包括具有近端和远端的细长构件，与细长构件的远端相关联的多个输注端口以及用于选择性地将引导器端口与至少一个输注端口流体连通的选择器机构。 还提供了一种治疗组织的方法。 该方法包括将医疗装置引入组织中，选择组织的区域以治疗，将医疗装置定位在该区域附近，以及通过该装置引入药物以仅对该区域进行治疗。
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公开(公告)号：US08412348B2
公开(公告)日：2013-04-02
申请号：US10841069
申请日：2004-05-06
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/3787 , A61N2001/0585
摘要： An expandable intravascular medical device is provided. The medical device comprises an expandable tubular body that includes an integrated resilient support structure that forms a plurality of electrically conductive regions to which the lead(s) is coupled. The tubular body further includes at least one electrically insulative element disposed between the conductive regions. In one embodiment, the support structure is skeletal in nature, e.g., it can be formed of a mesh, braid, or coil. The conductive regions can be variously formed by the support structure. For example, the support structure may comprise electrically conductive sub-structures that form the conductive regions. In this case, the sub-structures may be mechanically linked together by the insulative element(s), or they can be directly linked together, and the insulative element(s) can take the form of insulative layer(s) disposed on one or more of the conductive sub-structures. As another example, the support structure can have a conductive core and insulative material disposed over portions of the conductive core. In this case, the exposed core portions form the conductive regions, and the unexposed core portions form the insulative element(s).
摘要翻译： 提供可扩张血管内医疗装置。 医疗装置包括可扩张的管状体，其包括形成多个导电区域的集成的弹性支撑结构，引线与该多个导电区域相连。 管状体还包括设置在导电区域之间的至少一个电绝缘元件。 在一个实施例中，支撑结构本质上是骨架的，例如，其可以由网，编织物或线圈形成。 导电区域可以由支撑结构各种形成。 例如，支撑结构可以包括形成导电区域的导电子结构。 在这种情况下，子结构可以通过绝缘元件机械地连接在一起，或者它们可以直接连接在一起，并且绝缘元件可以采取设置在一个或多个绝缘元件上的绝缘层的形式， 更多的导电子结构。 作为另一示例，支撑结构可以具有设置在导电芯的部分上方的导电芯和绝缘材料。 在这种情况下，露出的芯部形成导电区域，未曝光的芯部形成绝缘元件。
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9.发明授权Intravascular self-anchoring electrode body with arcuate springs, spring loops, or arms 有权血管内自身锚定电极主体具有弧形弹簧，弹簧环或手臂公开(公告)号：US07231260B2
公开(公告)日：2007-06-12
申请号：US10841070
申请日：2004-05-06
IPC分类号： A61N1/00
CPC分类号： A61N1/057 , A61N1/3787 , A61N2001/0585
摘要： An expandable intravascular medical device comprises an arcuate spring configured to be expanded into contact with the inner surface of a blood vessel. Another medical device comprises an electrode support structure, e.g., a non-tubular arcuate structure or a cylindrical member, and a plurality of resilient spring loops laterally extending from the support structure. The contact created between the loops and a blood vessel is sufficient to anchor the medical device within the blood vessel. In another embodiment, the medical device comprises an elongated member and two resilient spring arms extending distally from the elongated member. The arms are configured to be laterally moved towards each other to place the medical device in a collapsed geometry, and configured to be laterally moved away from each into contact with an inner surface of a blood vessel to place the medical device an expanded geometry.
摘要翻译： 可扩张血管内医疗装置包括弓形弹簧，其被构造成膨胀成与血管的内表面接触。 另一医疗装置包括电极支撑结构，例如非管状弓形结构或圆柱形构件，以及从支撑结构横向延伸的多个弹性弹簧环。 在环和血管之间产生的接触足以将医疗装置锚定在血管内。 在另一个实施例中，医疗装置包括细长构件和从细长构件向远侧延伸的两个弹性弹簧臂。 臂被配置为朝向彼此横向移动以将医疗装置放置在折叠的几何形状中，并且被构造成横向移动远离每个与血管的内表面接触，以将医疗装置放置成扩展的几何形状。
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公开(公告)号：US07177702B2
公开(公告)日：2007-02-13
申请号：US10799270
申请日：2004-03-12
IPC分类号： A61N1/00
CPC分类号： A61N1/0553 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0558
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The spring layer is configured to urge that insulative membrane into an expanded geometry. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force.
摘要翻译： 提供医疗用铅和治疗患者的方法。 医用引线包括电绝缘膜，与绝缘膜相关联的弹性弹簧元件，以及与绝缘膜相关联的至少一个电极。 弹簧层构造成将绝缘膜推动成扩展的几何形状。 医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。 可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态 压缩力。
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