公开(公告)号：US20070255376A1

公开(公告)日：2007-11-01

申请号：US11380234

申请日：2006-04-26

申请人： Koen Michels ,  Jean-Luc Jansens ,  Victor Duysens ,  Paulus Adams ,  Paulus Van Venrooij ,  Markus Lazeroms ,  Fredric Lindemans

发明人： Koen Michels ,  Jean-Luc Jansens ,  Victor Duysens ,  Paulus Adams ,  Paulus Van Venrooij ,  Markus Lazeroms ,  Fredric Lindemans

IPC分类号： A61N1/00

CPC分类号： A61N1/0587

摘要： Certain aspects of the disclosure pertain to methods and apparatus for providing positive fixation of medical components to a portion of incised pericardial tissue. Accordingly, a resilient member protrudes through an incision in the pericardium and produces a positive biasing force to adjacent pericardial tissue against a side surface of an attached body structure. The resilient member can optionally be compressed during implantation and then relaxed to thereafter provide the positive biasing force. Diverse medical components can thus be safely and reliably chronically deployed into the pericardial space, including without limitation, cardiac sensing/pacing, defibrillation and/or cardioversion electrodes, mechanical and/or metabolic sensors and the like. More than one body structure can be linked to a single medical electrical lead and the medical components can couple within and/or upon a portion of the body structure, the resilient member, and the lead in myriad configurations.

摘要翻译： 本公开的某些方面涉及用于向切开的心包组织的一部分提供医疗部件的正面固定的方法和装置。 因此，弹性构件通过心包中的切口突出，并且相对于附接体结构的侧表面产生相邻心包组织的正偏置力。 弹性构件可以可选地在植入期间被压缩，然后松弛，之后提供正的偏压力。 因此，不同的医疗部件可以安全可靠地长期地部署到心包空间中，包括但不限于心脏感测/起搏，除颤和/或心脏复律电极，机械和/或代谢传感器等。 多个主体结构可以连接到单个医疗电引线，并且医疗部件可以在各种构造中联接在身体结构，弹性构件和引线的一部分内和/或之内。

公开(公告)号：US20070255375A1

公开(公告)日：2007-11-01

申请号：US11380228

申请日：2006-04-26

申请人： Koen Michels ,  Fredric Lindemans ,  Jean-Luc Jansens

发明人： Koen Michels ,  Fredric Lindemans ,  Jean-Luc Jansens

IPC分类号： A61N1/00

CPC分类号： A61N1/0587

摘要： The present disclosure pertains to methods and apparatus for providing positive fixation of medical components to a portion of pericardial tissue via both vacuum- and/or mechanically-assisted means. According to the invention, a source of vacuum couples via a lumen to a recessed portion of a body structure deployed into the pericardial space. The recessed portion is adapted to form a seal around its periphery with adjacent pericardial tissue so that when the recessed portion is evacuated, the tissue is drawn into the recessed portion. Then, a sharpened instrument, such as a stylet, is deployed through the lumen and pierces the tissue, thus anchoring the body structure. Other embodiment involve coupling a source fluid for delivery to the pericardial space (e.g., contrast media; saline solution; biological, genetic and pharmaceutical substances and the like).

摘要翻译： 本公开涉及用于通过真空和/或机械辅助手段将医疗部件正向固定到心包组织的一部分的方法和装置。 根据本发明，真空源经由内腔耦合到部署到心包空间的身体结构的凹陷部分。 凹部适于围绕其周边与相邻的心包组织形成密封，使得当凹部被抽真空时，组织被拉入凹部。 然后，诸如探针之类的尖锐的器械通过内腔部署并刺穿组织，从而锚固身体结构。 其他实施方案涉及将源流体偶联用于递送至心包空间（例如，造影剂;盐溶液;生物，遗传和药物物质等）。

公开(公告)号：US07664550B2

公开(公告)日：2010-02-16

申请号：US10999334

申请日：2004-11-30

申请人： Olaf J. Eick ,  Koen Michels

发明人： Olaf J. Eick ,  Koen Michels

IPC分类号： A61N1/372

CPC分类号： A61N1/08 ,  A61N1/056 ,  A61N1/3704 ,  A61N2001/0585

摘要： Displacement or migration of a left ventricular lead located within the coronary sinus or coronary veins of the heart is detected by comparing an electrogram (EGM) waveform pattern from the lead with a stored baseline EGM waveform pattern. Based upon the extent of lead migration, if any, a lead displacement may produce an annunciating response. The patient may be alerted, an electrical stimulus applied through the lead may be adjusted to compensate for lead migration, or an alternative electrode on the lead may be used for EGM sensing and pacing.

摘要翻译： 通过将来自引线的电描记图（EGM）波形图案与存储的基线EGM波形图案进行比较来检测位于冠状窦或心脏冠状静脉内的左心室引导位移或迁移。 基于铅迁移的程度，如果有的话，铅排量可能会产生通知回应。 可以警告患者，可以调整通过引线施加的电刺激以补偿引线迁移，或者引线上的替代电极可用于EGM感测和起搏。

公开(公告)号：US20090270962A1

公开(公告)日：2009-10-29

申请号：US12414384

申请日：2009-03-30

申请人： Zhongping Yang ,  Amy Elizabeth Thompson ,  Paulus G. Adams ,  Koen Michels

发明人： Zhongping Yang ,  Amy Elizabeth Thompson ,  Paulus G. Adams ,  Koen Michels

IPC分类号： A61N1/05 ,  B23P25/00

CPC分类号： A61N1/05

摘要： An implantable passive fixation lead is disclosed. The passive fixation lead comprises an elongate lead body having at least one elongate conductive element. The lead body includes a proximal end and a distal end. A support member has a first surface and a second surface. The second surface is coupled to the distal end of the lead body. A linking material is coupled to the first surface of the support member. A bioadhesive material is coupled to the linking material. A removable cover is placed over the bioadhesive material.

摘要翻译： 公开了可植入的被动固定引线。 被动固定引线包括具有至少一个细长导电元件的细长引线体。 引线体包括近端和远端。 支撑构件具有第一表面和第二表面。 第二表面联接到引线主体的远端。 连接材料联接到支撑构件的第一表面。 生物粘附材料与连接材料连接。 可移除的盖子放置在生物粘附材料上。

公开(公告)号：US20050273129A1

公开(公告)日：2005-12-08

申请号：US11111466

申请日：2005-04-21

申请人： Koen Michels ,  Nicolaas Lokhoff ,  Matthew Bonner

发明人： Koen Michels ,  Nicolaas Lokhoff ,  Matthew Bonner

IPC分类号： A61B17/00 ,  A61B17/30 ,  A61B17/34

CPC分类号： A61B17/3423 ,  A61B17/3415 ,  A61B2017/00247 ,  A61B2017/00561 ,  A61B2017/306 ,  A61B2017/3486 ,  A61B2017/3488 ,  A61B2018/00392

摘要： Medical devices and methods for accessing an anatomical space of the body and particularly for penetrating the epicardium to access pericardial space and the epicardial surface of the heart in a minimally invasive manner employing suction are disclosed. The distal end of a tubular access sleeve having a sleeve wall surrounding a sleeve access lumen and extending between a sleeve proximal end and a sleeve distal end having a plurality of suction ports arrayed around the sleeve access lumen distal end opening is applied against an outer tissue layer. Suction is applied through the plurality of suction ports to a plurality of portions of the outer tissue layer. A perforation instrument is introduced through the sleeve access lumen to perforate the outer tissue layer to form an access perforation into the anatomic space while the applied suction stabilizes the outer tissue layer, whereby further treatment drugs and devices can be introduced into the anatomic space.

摘要翻译： 公开了用于访问身体的解剖空间，特别是用于穿透心外膜以采用抽吸的微创方式进入心包空间和心外膜表面的医疗装置和方法。 管状进入套管的远端具有围绕套管进入腔并且在套筒近端和套筒远端之间延伸的套筒壁，其具有围绕套筒入口腔远端开口排列的多个吸入口，抵靠外部组织 层。 通过多个抽吸端口将吸力施加到外部组织层的多个部分。 通过套管进入腔引入穿孔器械以使外部组织层穿孔，以在被施加的吸力稳定外部组织层时形成进入解剖空间的通路穿孔，从而可以将进一步的治疗药物和装置引入解剖空间。