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公开(公告)号：US20210319991A1
公开(公告)日：2021-10-14
申请号：US17259580
申请日：2019-07-25
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Miu TAKIMOTO , Takayuki OHMURA , Masahiro KOTANI
Abstract: A sample support is a sample support for sample ionization, including: a substrate formed with a plurality of through holes opening to a first surface and a second surface on a side opposite to the first surface; a conductive layer provided not to block the through hole in the first surface; and a frame body provided in a peripheral portion of the substrate to surround an ionization region in which a sample is ionized when viewed in a thickness direction of the substrate, in which a marker for recognizing a position in the ionization region is provided in the frame body.
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公开(公告)号：US20210257201A1
公开(公告)日：2021-08-19
申请号：US17262596
申请日：2019-06-19
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Miu TAKIMOTO , Takayuki OHMURA , Masahiro KOTANI
Abstract: A sample support is a sample support for sample ionization, including: a substrate formed with a plurality of through holes opening to a first surface and a second surface on a side opposite to the first surface; a conductive layer provided not to block the through hole in the first surface; and a reinforcement member disposed inside a part of the plurality of through holes.
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公开(公告)号：US20210043437A1
公开(公告)日：2021-02-11
申请号：US16966758
申请日：2019-01-16
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Masahiro KOTANI , Takayuki OHMURA
Abstract: Provided is a sample support body for ionization of a sample. The sample support body includes a substrate including a first surface and a second surface on sides opposite to each other, a first conductive layer provided on the first surface, and a second conductive layer provided on the second surface. A plurality of through-holes opening on the first surface and the second surface are formed in a predetermined region of the substrate, the predetermined region being for ionizing components of the sample. A width of a first opening on the first surface side is larger than a width of a second opening on the second surface side in each of the plurality of through-holes.
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公开(公告)号：US20210033564A1
公开(公告)日：2021-02-04
申请号：US16967046
申请日：2019-01-08
Applicant: Hamamatsu Photonics K.K.
Inventor： Yasuhide NAITO , Takayuki OHMURA , Masahiro KOTANI
IPC: G01N27/62
Abstract: A sample support body includes: a substrate having a first surface and a second surface opposite to each other; and a conductive layer provided on at least the first surface. A plurality of through-holes, which open to the second surface and to a third surface of the conductive layer which is locate at a side opposite to the substrate, are provided in the substrate and the conductive layer. A protective film having a higher affinity with water than the substrate is provided on the second surface, the third surface, and each inner surface of the plurality of through-holes.
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公开(公告)号：US20210027999A1
公开(公告)日：2021-01-28
申请号：US16966131
申请日：2018-11-30
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Masahiro KOTANI , Takayuki OHMURA
Abstract: A sample support body is a sample support body for ionizing a sample, including: a substrate formed with a plurality of first through holes opening to a first surface and a second surface opposite to each other; and a conductive layer provided at least on a peripheral portion of the first through hole in the first surface, in which in a partition portion provided between the adjacent first through holes, a plurality of second through holes communicating the adjacent first through holes are formed.
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Patent Agency Ranking
46.发明申请公开(公告)号：US20200279729A1
公开(公告)日：2020-09-03
申请号：US16762517
申请日：2018-10-05
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Yasuhide NAITO , Takayuki OHMURA , Masahiro KOTANI
Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, a conductive layer provided on at least the first surface, and a solvent provided in the plurality of through holes with refractoriness in a vacuum; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; and a third step of ionizing a component of the sample that is mixed with the solvent and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser beam while applying a voltage to the conductive layer.
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公开(公告)号：US20200273688A1
公开(公告)日：2020-08-27
申请号：US16647426
申请日：2018-08-03
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Takayuki OHMURA , Masahiro KOTANI
Abstract: Provided is a sample support body that includes a substrate, an ionization substrate, and a support. The ionization substrate has a plurality of measurement regions for dropping a sample on a second surface. A plurality of through-holes that open in a first surface and the second surface are formed at least in the measurement regions of the ionization substrate. A conductive layer is provided on peripheral edges of the through-holes at least on the second surface. The support has a first support provided on peripheral edges of the measurement regions on the first surface to separate the plurality of measurement regions when viewed in the direction in which the substrate and the ionization substrate face each other.
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公开(公告)号：US20200264134A1
公开(公告)日：2020-08-20
申请号：US16644743
申请日：2018-08-22
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Takayuki OHMURA , Masahiro KOTANI
Abstract: Provided is a sample support body that includes a substrate, an ionization substrate, a support, and a frame. The ionization substrate has a plurality of measurement regions for dropping a sample on second surface. A plurality of through-holes that open in a first surface and the second surface are formed at least in the measurement regions of the ionization substrate. A conductive layer is provided on peripheral edges of the through-holes at least on the second surface. The frame has a wall provided on peripheral edges of the measurement regions on the second surface to separate the plurality of measurement regions when viewed in the direction in which the substrate and the ionization substrate face each other.
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公开(公告)号：US20200219713A1
公开(公告)日：2020-07-09
申请号：US16647498
申请日：2018-07-31
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Masahiro KOTANI , Takayuki OHMURA
Abstract: A laser desorption/ionization method includes: a first process of preparing a sample support body that includes a substrate in which a plurality of through-holes are formed and a conductive layer that is provided on the first surface of the substrate; a second process of mounting a frozen sample on a mounting surface of a mount under a sub-freezing atmosphere, and fixing the sample support body to the mount in a state in which the second surface is in contact with the frozen sample; a third process of thawing the sample, and moving components of the thawed sample toward the first surface via the plurality of through-holes due to a capillary phenomenon; and a fourth process of irradiating the first surface with a laser beam while applying a voltage to the conductive layer, and ionizing the components that have moved toward the first surface.
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公开(公告)号：US20200219710A1
公开(公告)日：2020-07-09
申请号：US16647306
申请日：2018-07-31
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Masahiro KOTANI , Takayuki OHMURA
Abstract: A mass spectrometer includes: a chamber; a support that, in a state in which, in a sample support body that includes a substrate in which a plurality of through-holes open in first and second surfaces are formed and a conductive layer that is at least provided on the first surface, the second surface thereof is in contact with a sample, supports the sample and the sample support body; a laser beam irradiation part that irradiates the first surface with a laser beam; a voltage application part that applies a voltage to the conductive layer; an ion detection part that, detects the ionized components of the sample in a space inside the chamber; a first light irradiation part that irradiates the sample with a first light from a side of the substrate; and an imaging part that obtains a reflected light image of the sample by the first light.
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