公开(公告)号：US07329330B2

公开(公告)日：2008-02-12

申请号：US10451738

申请日：2002-01-08

Applicant: Martin Gall ,  Gerd Kaibel ,  Thomas Krug ,  Harald Rust ,  Frank Stein

Inventor： Martin Gall ,  Gerd Kaibel ,  Thomas Krug ,  Harald Rust ,  Frank Stein

IPC: B01D3/14 ,  B01D3/42 ,  C07C29/80

CPC classification number: C07D315/00 ,  B01D3/14 ,  B01D3/141 ,  C07C29/80 ,  Y10S203/20 ,  C07C31/26 ,  C07C31/20

Abstract: A process for working up by distillation the crude products obtained in the process according to DE-A 196 07 954 and containing 1,6-hexanediol (HDO), 1,5-pentanediol (PDO) or caprolactone (CLO) in order to obtain the corresponding pure products, the working-up by distillation being carried out in each case in a dividing wall column (TK) in which a dividing wall (T) is arranged in the longitudinal direction of the column with formation of an upper common column region (1), a lower common column region (6), a feed section (2, 4) having a rectification section (2) and stripping section (4), and a take-off section (3, 5) having a stripping section (3) and rectification section (5), with feeding of the respective crude product HDO, PLO or CLO in the middle region of the feed section (2, 4) and removal of the high boiler fraction (C) from the bottom of the column, of the low boiler fraction (A) via the top of the column and of the medium boiler fraction (B) from the middle region of the take-off section (3, 5), or in thermally coupled columns.

Abstract translation: 通过蒸馏处理根据DE-A 196 07954的方法获得的含有1,6-己二醇（HDO），1,5-戊二醇（PDO）或己内酯（CLO）的粗产物的方法，以获得 相应的纯产品，在各种情况下在分隔壁塔（TK）中进行蒸馏处理，其中分隔壁（T）沿塔的纵向方向排列，形成上共同区域 （1），较低的公共列区域（6），具有整流部分（2）和汽提部分（4）的进料部分（2,4）和具有汽提部分的取出部分（3,5） （3）和整流部分（5），在进料部分（2,4）的中间区域供给相应的粗产物HDO，PLO或CLO，并将高沸点馏分（C）从底部 通过塔顶和中间锅炉馏分（B）从中间排出低沸点馏分（A） 起飞段（3,5）的区域，或热耦合柱。

公开(公告)号：US06900332B2

公开(公告)日：2005-05-31

申请号：US10348961

申请日：2003-01-23

Applicant: Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Michael Becker

Inventor： Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Michael Becker

IPC: C07D213/67 ,  C07D263/42 ,  C07D263/30

CPC classification number: B01D3/141 ,  C07D213/67 ,  C07D263/42

Abstract: The present invention relates to a process for preparing 5-alkoxy-substituted oxazoles, in particular for preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives.

Abstract translation: 本发明涉及一种制备5-烷氧基取代的恶唑的方法，特别是制备4-甲基-5-烷氧基取代的恶唑，以及制备吡哆醇衍生物的方法。

公开(公告)号：US06713630B2

公开(公告)日：2004-03-30

申请号：US10300629

申请日：2002-11-21

Applicant: Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Andre Mohry

Inventor： Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Andre Mohry

IPC: C07D26330

CPC classification number: B01D3/141 ,  C07D263/42

Abstract: The present invention relates to a process for continuously preparing 5-alkoxy-substituted oxazoles, in particular for continuously preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives.

公开(公告)号：US06692616B2

公开(公告)日：2004-02-17

申请号：US10168980

申请日：2002-06-26

Applicant: Matthias Dernbach ,  Detlef Kratz ,  Achim Stammer ,  Harald Rust ,  Gerhard Schulz

Inventor： Matthias Dernbach ,  Detlef Kratz ,  Achim Stammer ,  Harald Rust ,  Gerhard Schulz

IPC: B01D314

CPC classification number: C07C29/80 ,  C07C31/225 ,  C07C31/12 ,  C07C31/245 ,  C07C31/04

Abstract: A process is disclosed for the purification, by distillation, of trimethylolpropane originating from the hydrogenation of 2,2-dimethylolbutanal, said process including the following steps: (a) reaction of n-butyraldehyde with formaldehyde in the presence of catalytic amounts of a tertiary amine, and hydrogenation of the resulting mixture to give a mixture containing trimethylolpropane; (b) separation of water, methanol, trialkylamine and/or trialkylammonium formate by distillation; (c) heating of the residue obtained in (b) under reduced pressure to a temperature at which TMP is volatile and compounds boiling above TMP are cleaved, in order to separate off, by distillation, TMP and compounds more volatile than TMP; (d) distillation of the distillate obtained in (c) in order to separate off the more volatile compounds and recover pure TMP; and (e) optional distillation of the TMP obtained in (d) in order to recover TMP with a low APHA color index. A process is also disclosed in which trialkylammonium formate is distilled under mild conditions from crude mixtures of polyhydric alcohols, predominantly trimethylolpropane.

Abstract translation: 公开了一种通过蒸馏纯化来自2,2-二羟甲基丁烷的氢化的三羟甲基丙烷的方法，所述方法包括以下步骤：（a）在催化量的叔碳酸存在下，正丁醛与甲醛的反应 胺，并氢化得到的混合物，得到含有三羟甲基丙烷的混合物;（b）通过蒸馏分离水，甲醇，三烷基胺和/或三烷基铵甲酸盐;（c）将（b）中得到的残余物在减压下加热至 TMP挥发的温度和TMP沸点高的化合物被切割，以便通过蒸馏分离TMP和比TMP更易挥发的化合物;（d）蒸馏（c）中获得的馏出物，以分离出更多的 挥发性化合物，回收纯TMP; 为了回收具有低APHA颜色指数的TMP，还可以任选地蒸馏（d）中获得的TMP。还公开了一种方法，其中在温和条件下从多元醇，主要是三羟甲基丙烷的粗混合物中蒸馏出三烷基铵甲酸盐。

公开(公告)号：US6011157A

公开(公告)日：2000-01-04

申请号：US180626

申请日：1998-11-12

Applicant: Manfred Julius ,  Harald Rust ,  Alfred Krause ,  Hardo Siegel ,  Wolfgang Siegel ,  Tom Witzel

Inventor： Manfred Julius ,  Harald Rust ,  Alfred Krause ,  Hardo Siegel ,  Wolfgang Siegel ,  Tom Witzel

IPC: C07D211/58 ,  C07D211/56 ,  C07D221/20

CPC classification number: C07D211/56

Abstract: A process for purifying crude piperidines of the formula I ##STR1## where R.sup.1 to R.sup.4 are C.sub.1 -C.sub.6 -alkyl, or R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4 together are a CH.sub.2 -chain of 2 to 5 carbons, which comprises, in a first step, removing high-boiling substances and, if present, water from the crude piperidines by distillation; in a second step, adding from 0.01 to 5% by weight, based on the product of the first step, as a reducing agent; and, in a third step, isolating the piperidines by distillation.

Abstract translation: PCT No.PCT / EP97 / 02822 Sec。 371日期：1998年11月12日 102（e）1998年11月12日日期PCT提交1997年5月30日PCT公布。 出版物WO97 / 46529 日期1997年12月11日一种用于纯化式I的粗哌啶的方法，其中R 1至R 4为C 1 -C 6烷基，或R 1和R 2和/或R 3和R 4一起为2至5个碳的CH 2链，其包含 在第一步中，通过蒸馏除去高沸点物质，如果存在，则从粗哌啶衍生出水; 在第二步中，以作为还原剂的第一步产物为基准添加0.01〜5重量％ 并且在第三步骤中，通过蒸馏分离哌啶。

公开(公告)号：US5985100A

公开(公告)日：1999-11-16

申请号：US11700

申请日：1998-02-17

Applicant: Maik Aron ,  Harald Rust

Inventor： Maik Aron ,  Harald Rust

IPC: C07C27/28 ,  C07C29/80 ,  C07C31/12 ,  C07C41/42 ,  C07C43/04 ,  B01D3/00

CPC classification number: C07C41/42 ,  C07C29/80 ,  Y10S203/20

Abstract: Butanol and dibutyl ether are separated from a mixture containing water, dibutyl ether and n-butanol, 2-butanol and/or isobutanol by a process in whicha) the mixture is introduced into a first distillation column, essentially butanol is separated off at the bottom of this distillation column and the mixture taken off at the top of the distillation columnb) is introduced into a second distillation column and essentially dibutyl ether is separated off at the bottom of this second distillation column and the mixture formed at the top of the second distillation column is removed,c) the second distillation column being operated at a higher pressure than the first distillation column and at least one of the two mixtures taken off via the top of the distillation columns being subjected to phase separation, only the organic phase separated off being fed to the second distillation column in the case of phase separation downstream of the first distillation column, and separation into an aqueous and an organic phase also being effected in the case of phase separation downstream of the second distillation column, a part stream being recycled from the top or rectification section of the second distillation column to the first distillation column.

Abstract translation: PCT No.PCT / EP96 / 03762 Sec。 371日期1998年2月17日 102（e）1998年2月17日PCT 1995年8月26日PCT PCT。 公开号WO97 / 08120 日期1997年3月6日丁醇和二丁醚由含有水，二丁醚和正丁醇，2-丁醇和/或异丁醇的混合物分离，其中a）将混合物引入第一蒸馏塔，基本上为丁醇 在该蒸馏塔的底部分离，将在蒸馏塔b）顶部排出的混合物引入第二蒸馏塔中，并且在该第二蒸馏塔的底部基本上分离出二丁基醚，并形成混合物 在第二蒸馏塔的顶部被除去，c）第二蒸馏塔在比第一蒸馏塔高的压力下操作，并且通过蒸馏塔的顶部排出的两种混合物中的至少一种经受相分离 在第一蒸馏塔下游相分离的情况下，仅分离出分离的有机相进入第二蒸馏塔，分离 在第二蒸馏塔下游的相分离的情况下也进行水和有机相的离子化，将一部分物流从第二蒸馏塔的顶部或精馏段再循环到第一蒸馏塔。

公开(公告)号：US5002639A

公开(公告)日：1991-03-26

申请号：US566677

申请日：1990-08-13

Applicant: Werner Steck ,  Harald Rust ,  Helmut Lermer ,  Fritz Naeumann

Inventor： Werner Steck ,  Harald Rust ,  Helmut Lermer ,  Fritz Naeumann

IPC: C07C253/34

CPC classification number: C07C253/34

Abstract: A process for the separation of ortho-, meta- and para-tolunitrile from ternary mixtures of isomers entails removing ortho-tolunitrile from these mixtures by distillation under pressures of from 10.sup.2 and 10.sup.5 Pa and with a reflux ratio of from 1:1 to 200:1, and distilling the remaining binary mixture of meta- and para-tolunitrile to concentrate to more than 75 mol-% para-tolunitrile, and freezing out the paratolunitrile at below 26.degree. C., and a process for the preparation of suitable ternary mixtures of isomers entails isomerization of pure ortho-, meta- or para-tolunitrile or mixtures thereof at from 380.degree. to 580.degree. C. on zeolite catalysts.

Abstract translation: 从异构体的三元混合物中分离原始，间位和对 - 仲腈的方法需要通过在102和105Pa的压力下回流，从1:1至200的回流比从这些混合物中除去邻 - ：1，并蒸馏剩余的元 - 和对 - 仲腈的二元混合物以浓缩至大于75mol％的对 - 仲腈，并在低于26℃下冷冻副产物腈，以及制备合适的三元 异构体的混合物需要在380-580℃下对沸石催化剂上的纯邻位，间位或对 - 甲苯腈或其混合物异构化。