Method for the production of 2=-keto-l-gulonic acid C4C10 alkyl esters
    2.
    发明授权
    Method for the production of 2=-keto-l-gulonic acid C4C10 alkyl esters 失效
    制备2 =酮-1-古洛糖酸C 4 C 10烷基酯的方法

    公开(公告)号:US07091375B2

    公开(公告)日:2006-08-15

    申请号:US10534334

    申请日:2003-11-07

    CPC classification number: C07H7/027 Y02P20/127

    Abstract: The invention relates to a method for producing 2-keto-L-gulonic acid-C4–C10 alkyl ester by esterifying 2-keto-L-gulonic acid (KGS) with an unsaturated, branched or unbranched C4–C10 alcohol. The inventive method is characterized by the fact that an aqueous KGS solution is reacted with a C4–C10 alcohol up to an esterification degree of 20 to 70 percent in a pre-esterification process carried out under acidic catalysis conditions; and the obtained product is dehydrogenated with an unsaturated, branched or unbranched C4–C10 alcohol in a continuous rectification device, whereby the esterification reaction continues, n-butanol preferably being used as the alkyl alcohol. In a preferred embodiment, the aqueous KGS solution is concentrated up to or beyond the limit of solubility prior to the esterification process, preferably by catalyzing a homogeneous or heterogeneous catalyst, especially sulfonic acid, at temperatures of 50 to 120° C. In another embodiment, the produced KGS ester is reacted in one or several additional steps so as to obtain L-ascorbic acid.

    Abstract translation: 本发明涉及通过酯化2-酮-L-古洛糖酸(KGS)制备2-酮-L-古洛糖酸-C 4 -C 10烷基酯的方法 )与不饱和,支链或非支链C 4 -C 10醇。 本发明的方法的特征在于,将KGS水溶液与C 4 -C 10 - 醇反应,直到酯化程度为20至70% 在酸性催化条件下进行酯化过程; 并将得到的产物用连续精馏装置中的不饱和支链或非支链C 4 -C 10醇脱氢,由此继续进行酯化反应,正丁醇优选为 用作烷基醇。 在优选的实施方案中,在酯化过程之前,优选通过在50至120℃的温度下催化均相或多相催化剂,特别是磺酸,将KGS水溶液浓缩至或超过溶解度的极限。在另一个实施方案中 ,所制备的KGS酯在一个或几个附加步骤中反应,以获得L-抗坏血酸。

    Method for the production of 2 =-keto-l-gulonic acid c4-c10 alkyl esters
    4.
    发明申请
    Method for the production of 2 =-keto-l-gulonic acid c4-c10 alkyl esters 失效
    制备2 =酮-1-古洛糖酸c4-c10烷基酯的方法

    公开(公告)号:US20060058550A1

    公开(公告)日:2006-03-16

    申请号:US10534334

    申请日:2003-11-07

    CPC classification number: C07H7/027 Y02P20/127

    Abstract: The invention relates to a method for producing 2-keto-L-gulonic acid-C4-C10 alkyl ester by esterifying 2-keto-L-gulonic acid (KGS) with an unsaturated, branched or unbranched C4-C10 alcohol. The inventive method is characterized by the fact that an aqueous KGS solution is reacted with a C4-C10 alcohol up to an esterification degree of 20 to 70 percent in a pre-esterification process carried out under acidic catalysis conditions; and the obtained product is dehydrogenated with an unsaturated, branched or unbranched C4-C10 alcohol in a continuous rectification device, whereby the esterification reaction continues, n-butanol preferably being used as the alkyl alcohol. In a preferred embodiment, the aqueous KGS solution is concentrated up to or beyond the limit of solubility prior to the esterification process, preferably by catalyzing a homogeneous or heterogeneous catalyst, especially sulfonic acid, at temperatures of 50 to 120 ° C. In another embodiment, the produced KGS ester is reacted in one or several additional steps so as to obtain L-ascorbic acid.

    Abstract translation: 本发明涉及通过酯化2-酮-L-古洛糖酸(KGS)制备2-酮-L-古洛糖酸-C 4 -C 10烷基酯的方法 )与不饱和,支链或非支链C 4 -C 10醇。 本发明的方法的特征在于,将KGS水溶液与C 4 -C 10 - 醇反应,直到酯化程度为20至70% 在酸性催化条件下进行酯化过程; 并将得到的产物用连续精馏装置中的不饱和支链或非支链C 4 -C 10醇脱氢,由此继续进行酯化反应,正丁醇优选为 用作烷基醇。 在优选的实施方案中,在酯化过程之前,优选通过在50至120℃的温度下催化均相或多相催化剂,特别是磺酸,将KGS水溶液浓缩至或超过溶解度的极限。在另一个实施方案中 ,所制备的KGS酯在一个或几个附加步骤中反应,以获得L-抗坏血酸。

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