公开(公告)号：US08791086B2

公开(公告)日：2014-07-29

申请号：US13386154

申请日：2010-07-22

申请人： Kazunori Kataoka ,  Shourong Wu ,  Nobuhiro Nishiyama ,  Keiji Itaka ,  Hiroyuki Koyama ,  Takuya Hashimoto ,  Yuichi Tei

发明人： Kazunori Kataoka ,  Shourong Wu ,  Nobuhiro Nishiyama ,  Keiji Itaka ,  Hiroyuki Koyama ,  Takuya Hashimoto ,  Yuichi Tei

IPC分类号： A01N43/04 ,  C07H21/04 ,  C12N15/87

CPC分类号： A61K48/0025 ,  A61K31/7008 ,  A61K31/7088 ,  A61K38/18 ,  A61K45/06 ,  A61K47/595 ,  A61K47/60 ,  A61K47/6455 ,  C12N15/87 ,  A61K2300/00

摘要： The present invention aims to provide a gene delivery system with higher safety and higher sustainability, which is effective for the treatment of ischemic diseases and the like, and the like. The present invention provides a pharmaceutical composition containing, as an active ingredient, a polyanionic substance that suppresses expression of PHD2, and containing a polyion complex of the polyanionic substance and a polycation chargeable polymer.

摘要翻译： 本发明旨在提供一种具有更高安全性和更高可持续性的基因递送系统，其对于治疗缺血性疾病等是有效的。 本发明提供含有抑制PHD2的表达的聚阴离子物质作为活性成分的药物组合物，并含有聚阴离子物质和聚阳离子带电性聚合物的聚离子络合物。

公开(公告)号：US08480165B2

公开(公告)日：2013-07-09

申请号：US12586384

申请日：2009-09-21

申请人： Hiroyuki Koyama ,  Koji Uchida

发明人： Hiroyuki Koyama ,  Koji Uchida

IPC分类号： B62D21/00

CPC分类号： B62D25/2027 ,  B62D25/087

摘要： A vehicle (1) includes first and second rear-floor cross members (4, 5) provided between right and left rear-floor side members (2, 2) in a vehicle body rear part and a pair of right and left rear-floor cross member braces (6, 6) provided therebetween. The second rear-floor cross member is formed by a three-member connected body consisting of right and left extension parts (52, 52) connected to the right and left rear-floor side members and a body part (51) arranged therebetween. The rear-floor cross member braces are connected to the body part (51) of the second rear-floor cross member. Shock energy of a shock load applied to the vehicle body rear part from the rear can be absorbed efficiently while the deformation of a rectangular region surrounded by the first and second rear-floor cross members and the right and left rear-floor cross member braces is restrained.

摘要翻译： 车辆（1）包括设置在车体后部的左右后地板侧构件（2,2）之间的第一和第二后地板横梁（4,5），以及一对左右后底板 横向构件支架（6,6）设置在它们之间。 第二后方横梁由三部件连接体形成，该三体连接体由连接于左右后底侧侧部件的左右延伸部52和52组成，并配置在其间的主体部51。 后地板横梁构件连接到第二后底板横梁的主体部分（51）。 能够有效地吸收从后方施加到车体后部的冲击载荷的冲击能量，而由第一和第二后部地板横向构件以及左右后方横向构件支架包围的矩形区域的变形是 束缚

公开(公告)号：US08276926B2

公开(公告)日：2012-10-02

申请号：US12818323

申请日：2010-06-18

申请人： Hiroyuki Koyama

发明人： Hiroyuki Koyama

IPC分类号： B62D21/11

CPC分类号： B62D25/088

摘要： A rear suspension spring support structure enables a rear side member to have an improved rigidity, and thus driving stability is improved. The rear suspension spring support structure has a rear cross member connected to a rear side member with a rear cross member extension being interposed therebetween. An extending portion, on a vehicle lateral side, of the rear cross member extension passes under the rear side member and extends to the vehicle lateral side of the rear side member. The extending portion is welded to a lower surface of the rear side member and a side surface of the vehicle lateral side. A coil spring bracket for receiving an upper end portion of the coil spring is joined to a lower surface of the rear cross member extension.

摘要翻译： 后悬架弹簧支撑结构使得后侧构件具有改善的刚性，从而提高了驾驶稳定性。 后悬架弹簧支撑结构具有连接到后侧构件的后横向构件，其间插入有后横向构件延伸部。 后横向构件延伸部的车辆横向侧的延伸部在后侧构件的下方延伸到后侧构件的车辆侧面侧。 延伸部分焊接到后侧构件的下表面和车辆横向侧的侧表面。 用于容纳螺旋弹簧的上端部的螺旋弹簧支架接合到后横向构件延伸部的下表面。

公开(公告)号：US20100013591A1

公开(公告)日：2010-01-21

申请号：US12227335

申请日：2007-05-14

申请人： Hiroyuki Koyama

发明人： Hiroyuki Koyama

IPC分类号： H01H71/00

CPC分类号： H01C7/027 ,  C22C14/00 ,  H01C1/1406 ,  H01C7/126 ,  H01H37/323 ,  H01H37/761 ,  H01H2037/768

摘要： It is provided a new protection device with a large current capacity, which can sense a relatively low abnormal temperature, and further has a simple construction and is not large in size. The protection device comprises (1) a polymer PTC device (18) having metal electrodes (14, 16) on the both main surfaces, and (2) a shape memory alloy lead (20), wherein the shape memory alloy lead is connected to the polymer PTC device by an electrically conductive adhesive (22) containing a thermoplastic resin and an electrically conductive filler.

摘要翻译： 提供了一种具有大电流容量的新型保护装置，其可以感测到相对较低的异常温度，并且还具有简单的结构并且尺寸不大。 保护装置包括（1）在两个主表面上具有金属电极（14,16）的聚合物PTC装置（18），和（2）形状记忆合金引线（20），其中形状记忆合金引线连接到 所述聚合物PTC装置通过包含热塑性树脂和导电填料的导电粘合剂（22）。

公开(公告)号：US07515032B2

公开(公告)日：2009-04-07

申请号：US10562279

申请日：2004-07-01

申请人： Hiroyuki Koyama ,  Arata Tanaka

发明人： Hiroyuki Koyama ,  Arata Tanaka

IPC分类号： H01C7/10

CPC分类号： H01C7/02

摘要： A PTC device is provided which is capable of surely functioning as the PTC device even in a wiring through which a large current flows. A combined PTC device (10, 10′) is composed of two PTC devices each containing a lamellar PTC element (12, 12′) which is composed of a polymeric PTC material and a pair of electrodes (14, 16; and 14′, 16′) which are arranged apart from each other on one side of the PTC element. The electrodes (14, 16) of one PTC device are respectively opposite to the electrodes (14′, 16′) of the other PTC device, and terminals (20, 21) are arranged between the respective opposite electrodes. The respective opposite electrodes and the terminal between them are electrically connected with each other.

摘要翻译： 提供一种PTC装置，即使在大电流流过的布线中也能够确实地用作PTC装置。 组合的PTC器件（10,10'）由两个PTC器件组成，每个PTC器件包含由聚合物PTC材料和一对电极（14,16;和14'）组成的片状PTC元件（12,12'）， 16'），其在PTC元件的一侧彼此分开布置。 一个PTC器件的电极（14,16）分别与另一个PTC器件的电极（14'，16'）相对，并且端子（20,21）布置在相应的相对电极之间。 相应的相对电极和它们之间的端子彼此电连接。

公开(公告)号：US20070170831A1

公开(公告)日：2007-07-26

申请号：US10576629

申请日：2004-10-20

申请人： Takashi Sato ,  Hiroyuki Koyama ,  Arata Tanaka

发明人： Takashi Sato ,  Hiroyuki Koyama ,  Arata Tanaka

IPC分类号： H01J61/52

CPC分类号： H01C7/02 ,  H01C1/1406

摘要： The present invention provides a PTC element having a novel structure and suitable for use in a starter circuit for a fluorescent lamp. The polymer PTC element (10) comprises a sheet-like body (1) made of a polymer PTC material, and the first and the second electrodes which are, for example, formed distant from each other on the same sheet surface of the sheet-like body (1) (the first electrodes 3a, 3b and the second electrodes 4a, 4b), wherein a clearance is formed between an inner wall of a through hole (7a, 7b) and a terminal (5a, 5b) as a space which at least partially traverses the sheet-like body (1) in its thickness direction.

摘要翻译： 本发明提供一种具有新颖结构并适用于荧光灯起动电路的PTC元件。 聚合物PTC元件（10）包括由聚合物PTC材料制成的片状体（1），并且第一和第二电极例如在片状体的同一片材表面上彼此远离地形成， 其特征在于，在贯通孔（7a，7b）的内壁与端子（5）之间形成有间隙（第一电极3a，3b和第二电极4a，4b） a，5b）作为在其厚度方向上至少部分地穿过片状体（1）的空间。

公开(公告)号：US20060244563A1

公开(公告)日：2006-11-02

申请号：US10562279

申请日：2004-07-01

申请人： Hiroyuki Koyama ,  Arata Tanaka

发明人： Hiroyuki Koyama ,  Arata Tanaka

IPC分类号： H01C10/12

CPC分类号： H01C7/02

摘要： A PTC device is provided which is capable of surely functioning as the PTC device even in a wiring through which a large current flows. A combined PTC device (10, 10′) is composed of two PTC devices respectively comprising a lamellar PTC element (12, 12′) which is composed of a polymeric PTC material and a pair of electrodes (14,16; and 14′,16′) which are arranged apart from each other on one side of the PTC element. The electrodes (14, 16) of one PTC device are respectively opposite to the electrodes (14′, 16′) of the other PTC device, and terminals (20, 21) are arranged between the respective opposite electrodes. The respective opposite electrodes and the terminal between them are electrically connected with each other.

摘要翻译： 提供一种PTC装置，即使在大电流流过的布线中也能够确实地用作PTC装置。 组合的PTC器件（10,10'）由两个PTC器件组成，分别包括由聚合物PTC材料和一对电极（14,16;和14'）组成的片状PTC元件（12,12'）， 16'），其在PTC元件的一侧彼此分开布置。 一个PTC器件的电极（14,16）分别与另一个PTC器件的电极（14'，16'）相对，并且端子（20,21）布置在相应的相对电极之间。 相应的相对电极和它们之间的端子彼此电连接。

公开(公告)号：US20060083755A1

公开(公告)日：2006-04-20

申请号：US10520333

申请日：2003-07-04

申请人： Kenji Motokawa ,  Hajime Kusuhara ,  Hiroyuki Koyama ,  Tsutomu Hohdatsu ,  Setsuo Arai

发明人： Kenji Motokawa ,  Hajime Kusuhara ,  Hiroyuki Koyama ,  Tsutomu Hohdatsu ,  Setsuo Arai

IPC分类号： A61K48/00 ,  C12Q1/70 ,  C12Q1/68 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/215 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/55588 ,  C12N2710/14143 ,  C12N2770/20022 ,  C12N2770/20034 ,  G01N33/56983

摘要： FIP vaccines were provided that use an N protein with a specific structure, or a fragment thereof, as an antigen. Preferred antigens of this invention are N proteins derived from a specific type I virus strain (KU-2). Vaccines comprising such an N protein confer preventive effects against a wide range of FIPVs. In addition, the N proteins are very safe because they do not comprise epitopes that enhance infection. Furthermore, preventive effects can be accomplished against type I viruses, which actually cause 70% or more of FIP.

摘要翻译： 提供使用具有特定结构的N蛋白或其片段作为抗原的FIP疫苗。 本发明优选的抗原是来源于特异性I型病毒株（KU-2）的N蛋白。 包含这样的N蛋白质的疫苗赋予针对各种FIPV的预防效果。 此外，N蛋白是非常安全的，因为它们不包含增强感染的表位。 此外，可以针对实际引起70％或更多FIP的I型病毒实现预防效果。

公开(公告)号：US06899479B2

公开(公告)日：2005-05-31

申请号：US10660028

申请日：2003-09-11

申请人： Katsumune Hayashi ,  Hiroyuki Koyama ,  Kouichi Yamada

发明人： Katsumune Hayashi ,  Hiroyuki Koyama ,  Kouichi Yamada

IPC分类号： B41J11/08 ,  B26D1/38 ,  B26D7/26 ,  B41J3/46 ,  B41J11/70 ,  B41J15/04 ,  B41J29/00 ,  B65H5/38 ,  G07G1/06 ,  B41F11/26 ,  B41F11/27 ,  B41F11/30

CPC分类号： B41J3/46 ,  B26D1/385 ,  B26D7/2614 ,  B41J11/70 ,  B41J15/042

摘要： A printer comprising a printing section that has a platen, a cutter section with a stationary blade and a movable blade and a printhead located oppositely on both sides of the guide path. A first unit is located on one side of the guide path arranged inside the casing which can be separated into a first casing member and a second casing member, holding either one of the stationary blade and the movable blade in the cutter section and a second unit located on the other side of the guide path that has either one of the other platen and the other printhead and either one of the other stationary blade and the other movable blade.

摘要翻译： 一种打印机，包括具有压板的打印部分，具有固定刀片的切割器部分和可动刀片以及位于引导路径两侧相对的打印头。 第一单元位于引导路径的一侧，布置在壳体内部，可以分离成第一壳体构件和第二壳体构件，将固定叶片和可动叶片中的任一个保持在切割器部分中，第二单元 位于引导路径的另一侧，其具有另一个压板和另一个打印头中的任一个，另一个固定刀片和另一个可动刀片中的任一个。