公开(公告)号：US5683710A

公开(公告)日：1997-11-04

申请号：US527535

申请日：1995-09-13

申请人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Saburo Otsuka ,  Takashi Kinoshita

发明人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Saburo Otsuka ,  Takashi Kinoshita

IPC分类号： A61K9/70 ,  A61K31/34 ,  A61K47/14 ,  A61P9/08 ,  A61P9/10 ,  A61F13/02

CPC分类号： A61K9/7061 ,  A61K31/34

摘要： A percutaneous absorption preparation for use in the administration of isosorbide dinitrate (ISDN) as a coronary vasodilator into the living body by percutaneous absorption, which has excellent adhesion to the skin and does not cause pain and damage to stratum corneum when peeled off, is disclosed. The pressure-sensitive adhesive layer comprises an acrylic copolymer prepared by copolymerization of a monomer mixture comprising a (meth)acrylic acid alkyl ester and a functional monomer as the essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms, and ISDN, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of ISDN is improved and the area of the preparation can be decreased.

摘要翻译： 公开了一种用于通过经皮吸收将硝酸异山梨酯（ISDN）作为冠状血管扩张剂施用于生物体的经皮吸收制剂，其对皮肤具有优异的粘附性，并且在剥离时不引起疼痛和对角质层的损伤 。 压敏粘合剂层包含通过将包含（甲基）丙烯酸烷基酯和官能单体作为主要组分的单体混合物，具有特定碳原子数的脂肪酸酯，具有特定碳原子数的单酸酯酯， 特定数量的碳原子和ISDN，并且压敏粘合剂层交联。 由于通过包含单酸甘油酯改善其皮肤粘合性，因此改善了ISDN的释放，并且可以减少制剂的面积。

公开(公告)号：US5650165A

公开(公告)日：1997-07-22

申请号：US551786

申请日：1995-11-07

申请人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Yutaka Suzuki ,  Saburo Otsuka

发明人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Yutaka Suzuki ,  Saburo Otsuka

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/14 ,  A61K47/32 ,  A01N29/02 ,  A61F13/02 ,  A61K31/035 ,  A61L15/16

CPC分类号： A61K9/7061 ,  A61K47/14 ,  A61K9/0014

摘要： This invention provides a percutaneous absorption preparation for use in the percutaneous administration of drugs for percutaneous absorption into the living body for the purpose of preventing or treating various diseases, which has excellent adhesion to the skin and does not cause pain and damage to corneum when peeled off. Its pressure-sensitive adhesive layer contains an acrylic copolymer comprising a (meth)acrylic acid alkyl ester and a functional monomer as essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms and a drug for percutaneous absorption, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of the drug from the preparation is improved and the area of the preparation can be miniaturized.

摘要翻译： 本发明提供一种经皮吸收制剂，用于经皮给药的药物，用于预防或治疗各种疾病，其对皮肤的粘附性优异，并且在剥离时不会引起疼痛和对角质的损伤 关闭 其压敏粘合剂层含有包含（甲基）丙烯酸烷基酯和官能单体作为必要组分的丙烯酸共聚物，具有特定碳原子数的脂肪酸酯，具有特定碳原子数的单酸甘油酯和 用于经皮吸收的药物，并且压敏粘合剂层交联。 由于通过包含单酸甘油酯改善其皮肤粘合性，因此药物从制剂中的释放得到改善，制剂的面积可以小型化。