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    Single sheet joining method and apparatus using the same
    1.
    发明申请
    Single sheet joining method and apparatus using the same 审中-公开
    单片接合方法及使用其的装置

    公开(公告)号：US20050199337A1

    公开(公告)日：2005-09-15

    申请号：US11071243

    申请日：2005-03-04

    申请人： Toshirou Nishikubo ,  Kazuo Kitada ,  Hiroshi Aizawa ,  Kazuhiro Higashio

    发明人： Toshirou Nishikubo ,  Kazuo Kitada ,  Hiroshi Aizawa ,  Kazuhiro Higashio

    IPC分类号： G02B5/30 ,  B65H37/04 ,  G02F1/1335 ,  G02F1/13363 ,  B32B31/00

    CPC分类号： G02F1/133528 ,  B32B37/02 ,  B32B37/226 ,  B32B38/0004 ,  B32B38/1858 ,  B32B2457/202 ,  G02F1/1303 ,  Y10T156/12 ,  Y10T156/1707

    摘要： A continuous band-shaped film is guided to a predetermined transport path by a guide roller while separating a protective film, and a single polarizer is supplied to a space between the guide roller and a liftable joining roller disposed above the guide roller so as to face the guide roller while separating a separator. In a state where the joining roller is lifted to create the space between the rollers, the polarizer is supplied to the space between the rollers. When the tip end of the polarizer reaches a predetermined position in the created space between the upper and lower rollers, the joining roller is lowered and the polarizer supplied synchronously with transportation of the film is pressed against the film and joined.

    摘要翻译： 连续的带状膜通过引导辊被引导到预定的传送路径，同时分离保护膜，并且单个偏振器被供应到引导辊和设置在引导辊上方的可升降接合辊之间的空间，以便面对 引导辊，同时分离分离器。 在连接辊被提升以产生辊之间的空间的状态下，偏振器被供应到辊之间的空间。 当偏光镜的末端到达上下辊之间的创建空间中的预定位置时，接合辊降低，并且与膜的输送同步地提供的偏振片被压靠在膜上并接合。

    Package structure of drug-containing pressure-sensitive adhesive sheet
    2.
    发明授权
    Package structure of drug-containing pressure-sensitive adhesive sheet 失效
    含药物压敏胶片的包装结构

    公开(公告)号：US5505306A

    公开(公告)日：1996-04-09

    申请号：US274162

    申请日：1994-07-14

    申请人： Hitoshi Akemi ,  Takashi Kinoshita ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Saburo Otsuka

    发明人： Hitoshi Akemi ,  Takashi Kinoshita ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Saburo Otsuka

    IPC分类号： A61B19/02 ,  A61F13/00 ,  A61F15/00 ,  A61K9/70 ,  A61B17/06

    CPC分类号： A61F15/001 ,  A61K9/703 ,  A61K9/7038 ,  A61B2050/002 ,  A61B2050/314 ,  A61F2013/00646 ,  A61F2013/00897

    摘要： A package structure, in which a drug-containing pressure-sensitive adhesive sheet comprising a support, a drug-containing pressure-sensitive adhesive layer, and a separator in this order is packaged and sealed in a packaging material, is disclosed, wherein unevenness is provided on at least one of the surface of the support on the side in contact with the inside of the packaging material, the surface of the separator on the side in contact with the inside of the packaging material, and the inside surface of the packaging material. The unevenness reduces the contact area between the packaging material and the sheet so that an adhesive, a plasticizer or any liquid component of the adhesive layer is prevented from adhering to the inside of the packaging material. Therefore, the sheet can easily be taken out of unit package on use.

    摘要翻译： 公开了一种封装结构，其中将包含载体，含药物的粘合剂层和隔膜的药物含压敏粘合片按包装材料包装和密封，其中不均匀性为 设置在与包装材料的内侧接触的一侧的支撑体的表面中的至少一个上，隔板的与包装材料的内部接触的一侧的表面和包装材料的内表面 。 不均匀性降低了包装材料和片材之间的接触面积，从而防止粘合剂，增塑剂或粘合剂层的任何液体成分粘附到包装材料的内部。 因此，在使用时，可以容易地将纸张从单元包装中取出。

    Adhering member and method for producing adhering member
    4.
    发明授权
    Adhering member and method for producing adhering member 有权
    附着构件及其制造方法

    公开(公告)号：US07749586B2

    公开(公告)日：2010-07-06

    申请号：US10140053

    申请日：2002-05-08

    申请人： Hitoshi Akemi ,  Kazuhiro Higashio

    发明人： Hitoshi Akemi ,  Kazuhiro Higashio

    IPC分类号： B32B9/00 ,  B32B33/00 ,  B65D65/28

    CPC分类号： C09J7/403 ,  C09J7/20 ,  C09J2205/31 ,  Y10T156/1064 ,  Y10T156/1082 ,  Y10T428/14 ,  Y10T428/1476 ,  Y10T428/149 ,  Y10T428/1495 ,  Y10T428/15

    摘要： An adhering member comprises an adhesive layer 2 of a thickness R formed on one surface of a backing 1, and a liner 3 of a thickness T laminated on the adhesive layer, and has a half-cut formed in the liner for making handleability satisfactory while preventing seepage of contents. The adhering member excellent in handleability and stability is obtained by providing, for example, the half-cut 4 having a rectangular or inverted triangular sectional shape, a groove width of 200 μm or less, and a groove depth of more than 14T/15 but less than (T+R).

    摘要翻译： 粘合部件包括形成在背衬1的一个表面上的厚度R的粘合剂层2和层压在粘合剂层上的厚度为T的衬垫3，并且具有形成在衬里中的半切口，以使操作性令人满意，而 防止内容物渗透。 通过提供例如具有矩形或倒三角形截面形状，槽宽度为200μm以下，槽深度大于14T / 15的半切割4，可以获得可操作性和稳定性优异的粘合部件，但是 小于（T + R）。

    Percutaneous absorption preparation
    7.
    发明授权
    Percutaneous absorption preparation 失效
    经皮吸收制剂

    公开(公告)号：US5683710A

    公开(公告)日：1997-11-04

    申请号：US527535

    申请日：1995-09-13

    申请人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Saburo Otsuka ,  Takashi Kinoshita

    发明人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Saburo Otsuka ,  Takashi Kinoshita

    IPC分类号： A61K9/70 ,  A61K31/34 ,  A61K47/14 ,  A61P9/08 ,  A61P9/10 ,  A61F13/02

    CPC分类号： A61K9/7061 ,  A61K31/34

    摘要： A percutaneous absorption preparation for use in the administration of isosorbide dinitrate (ISDN) as a coronary vasodilator into the living body by percutaneous absorption, which has excellent adhesion to the skin and does not cause pain and damage to stratum corneum when peeled off, is disclosed. The pressure-sensitive adhesive layer comprises an acrylic copolymer prepared by copolymerization of a monomer mixture comprising a (meth)acrylic acid alkyl ester and a functional monomer as the essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms, and ISDN, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of ISDN is improved and the area of the preparation can be decreased.

    摘要翻译： 公开了一种用于通过经皮吸收将硝酸异山梨酯（ISDN）作为冠状血管扩张剂施用于生物体的经皮吸收制剂，其对皮肤具有优异的粘附性，并且在剥离时不引起疼痛和对角质层的损伤 。 压敏粘合剂层包含通过将包含（甲基）丙烯酸烷基酯和官能单体作为主要组分的单体混合物，具有特定碳原子数的脂肪酸酯，具有特定碳原子数的单酸酯酯， 特定数量的碳原子和ISDN，并且压敏粘合剂层交联。 由于通过包含单酸甘油酯改善其皮肤粘合性，因此改善了ISDN的释放，并且可以减少制剂的面积。

    Percutaneous absorption preparation
    8.
    发明授权
    Percutaneous absorption preparation 失效
    经皮吸收制剂

    公开(公告)号：US5650165A

    公开(公告)日：1997-07-22

    申请号：US551786

    申请日：1995-11-07

    申请人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Yutaka Suzuki ,  Saburo Otsuka

    发明人： Hitoshi Akemi ,  Takateru Muraoka ,  Kazuhiro Higashio ,  Yutaka Suzuki ,  Saburo Otsuka

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/14 ,  A61K47/32 ,  A01N29/02 ,  A61F13/02 ,  A61K31/035 ,  A61L15/16

    CPC分类号： A61K9/7061 ,  A61K47/14 ,  A61K9/0014

    摘要： This invention provides a percutaneous absorption preparation for use in the percutaneous administration of drugs for percutaneous absorption into the living body for the purpose of preventing or treating various diseases, which has excellent adhesion to the skin and does not cause pain and damage to corneum when peeled off. Its pressure-sensitive adhesive layer contains an acrylic copolymer comprising a (meth)acrylic acid alkyl ester and a functional monomer as essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms and a drug for percutaneous absorption, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of the drug from the preparation is improved and the area of the preparation can be miniaturized.

    摘要翻译： 本发明提供一种经皮吸收制剂，用于经皮给药的药物，用于预防或治疗各种疾病，其对皮肤的粘附性优异，并且在剥离时不会引起疼痛和对角质的损伤 关闭 其压敏粘合剂层含有包含（甲基）丙烯酸烷基酯和官能单体作为必要组分的丙烯酸共聚物，具有特定碳原子数的脂肪酸酯，具有特定碳原子数的单酸甘油酯和 用于经皮吸收的药物，并且压敏粘合剂层交联。 由于通过包含单酸甘油酯改善其皮肤粘合性，因此药物从制剂中的释放得到改善，制剂的面积可以小型化。