公开(公告)号：US07094354B2

公开(公告)日：2006-08-22

申请号：US10326156

申请日：2002-12-19

Applicant: Michael J. Pugia ,  James A. Profitt ,  Lloyd Schulman ,  Gert Blankenstein ,  Ralf-Peter Peters

Inventor： Michael J. Pugia ,  James A. Profitt ,  Lloyd Schulman ,  Gert Blankenstein ,  Ralf-Peter Peters

IPC: G01N9/30

CPC classification number: B01L3/502753 ,  B01D21/262 ,  B01D2221/10 ,  B01L3/502723 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  B01L2400/088 ,  G01N33/491 ,  Y10T436/111666

Abstract: A microfluidic device provides separation of particles in a liquid sample, particularly, separation of a sample of whole blood into its components for further analysis. Separation into red blood cells and plasma occurs within a few seconds after the blood sample has been transferred into a separation chamber with the application of centrifugal force of less than about five times gravity. With the application of greater force measurement of hematocrit is possible.

Abstract translation: 微流体装置提供液体样品中的颗粒的分离，特别是将全血样品分离成其组分用于进一步分析。 在血液样品转移到分离室中后，在几分钟内分离成红细胞和血浆，其应用的离心力小于约5倍重力。 随着应用更大的力测量血细胞比容是可能的。

公开(公告)号：US4837227A

公开(公告)日：1989-06-06

申请号：US738507

申请日：1985-05-28

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D313/14

CPC classification number: C07D313/14

Abstract: Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as analgesic, antidepressant and anticonvulsant agents. A process for selectively reducing olefins by alkaline earth metals in loweralkanols is also disclosed.

Abstract translation: 公开了新的氨基烷基硫代二氧化硫蛋白，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽医制剂以及通过施用方法进行治疗。 这些化合物可用作镇痛药，抗抑郁药和抗惊厥药。 还公开了一种通过碱金属在低级烷醇中选择性还原烯烃的方法。

公开(公告)号：US4775672A

公开(公告)日：1988-10-04

申请号：US14741

申请日：1987-02-13

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D337/14 ,  A61K31/38 ,  C07D409/12

CPC classification number: C07D337/14

Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.

公开(公告)号：US4766143A

公开(公告)日：1988-08-23

申请号：US13990

申请日：1987-02-12

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D337/14 ,  A61K31/38

CPC classification number: C07D337/14

Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.

公开(公告)号：US4668695A

公开(公告)日：1987-05-26

申请号：US546642

申请日：1983-10-28

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D337/14 ,  A61K31/38

CPC classification number: C07D337/14

Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.

公开(公告)号：US4528399A

公开(公告)日：1985-07-09

申请号：US558076

申请日：1983-12-05

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: C07C45/63 ,  C07D333/54 ,  C07D333/56 ,  C07D333/64 ,  C07D333/76 ,  C07C149/32

CPC classification number: C07D333/54 ,  C07C309/00 ,  C07C323/00 ,  C07C45/63 ,  C07D333/56 ,  C07D333/64 ,  C07D333/76

Abstract: Novel benzo[b]thiophenes, compositions containing same, process for the preparation thereof and methods of reducing blood pressure and producing diuresis by administration of the compounds and compositions are disclosed.

Abstract translation: 公开了新的苯并[b]噻吩，含有它们的组合物，其制备方法和通过施用化合物和组合物降低血压和产生利尿的方法。

公开(公告)号：US4345081A

公开(公告)日：1982-08-17

申请号：US198233

申请日：1980-10-17

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: C07D211/64 ,  C07D471/10

CPC classification number: C07D471/10 ,  C07D211/64

Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.

Abstract translation: 描述了新的螺[二氢吲哚-3,4'-哌啶]和相关化合物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药和镇定剂。 还描述了制备二氢吲哚环的新方法。

公开(公告)号：US4198419A

公开(公告)日：1980-04-15

申请号：US2349

申请日：1979-01-10

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: A61K31/443 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/451 ,  A61P25/04 ,  A61P25/08 ,  A61P25/24 ,  A61P25/26 ,  C07C67/00 ,  C07C313/00 ,  C07C323/62 ,  C07D211/32 ,  C07D211/64 ,  C07D405/06

CPC classification number: C07C323/00 ,  C07D211/32

Abstract: Novel phenylthiophenylpiperidines and methods of preparing same are described. These compounds are useful as analgetics, antidepressants, anticonvulsants and intermediates for preparing other pharmaceutically active compounds.

Abstract translation: 描述了新的苯硫基苯基哌啶及其制备方法。 这些化合物可用作止痛剂，抗抑郁药，抗惊厥药和用于制备其它药物活性化合物的中间体。

公开(公告)号：US4198417A

公开(公告)日：1980-04-15

申请号：US2346

申请日：1979-01-10

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: C07C43/29 ,  A61K31/443 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/451 ,  A61P25/04 ,  A61P25/08 ,  A61P25/24 ,  A61P25/26 ,  C07C41/00 ,  C07C43/225 ,  C07C43/23 ,  C07C43/295 ,  C07C51/00 ,  C07C65/21 ,  C07C67/00 ,  C07C253/00 ,  C07C255/37 ,  C07D211/32 ,  C07D211/64 ,  C07D405/06

CPC classification number: C07D211/64 ,  C07C43/225 ,  C07C43/23 ,  C07D211/32

Abstract: Novel phenoxyphenylpiperidines and methods of preparing same are described. These compounds are useful as analgetics, antidepressants, anticonvulsants and intermediates for preparing other pharmaceutically active compounds.

Abstract translation: 描述了新型苯氧基苯基哌啶及其制备方法。 这些化合物可用作止痛剂，抗抑郁药，抗惊厥药和用于制备其它药物活性化合物的中间体。