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公开(公告)号：US08304254B2
公开(公告)日：2012-11-06
申请号：US12598150
申请日：2008-03-14
Applicant: Michael J. Pugia , James A. Profitt
Inventor： Michael J. Pugia , James A. Profitt
IPC: G01N1/38
CPC classification number: G01N35/1016 , G01N2035/1034 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
Abstract: Assays in which samples of biological fluids are dispensed onto reagent-containing porous substrates are improved in the accuracy and repeatability by dispensing the biological fluids in two or more fractions thereof, separated by intervals in which the biological fluid is not dispensed. Reagents and other fluids may be dispensed during the intervals when the biological fluid is not dispensed. Alternatively, reagents and other fluids may be dispensed in a similar manner onto substrates already containing biological fluids.
Abstract translation: 生物流体样品分配到含有试剂的多孔基材上的测定通过将生物流体分配在两个或更多个部分中，通过分配生物流体不分配的间隔而提高了精度和重复性。 在不分配生物流体的间隔期间，可以分配试剂和其它流体。 或者，可以以类似的方式将试剂和其它流体分配到已经含有生物流体的基底上。
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公开(公告)号：US20100255592A1
公开(公告)日：2010-10-07
申请号：US12598150
申请日：2008-03-14
Applicant: Michael J. Pugia , James A. Profitt
Inventor： Michael J. Pugia , James A. Profitt
CPC classification number: G01N35/1016 , G01N2035/1034 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
Abstract: Assays in which samples of biological fluids are dispensed onto reagent-containing porous substrates are improved in the accuracy and repeatability by dispensing the biological fluids in two or more fractions thereof, separated by intervals in which the biological fluid is not dispensed. Reagents and other fluids may be dispensed during the intervals when the biological fluid is not dispensed. Alternatively, reagents and other fluids may be dispensed in a similar manner onto substrates already containing biological fluids.
Abstract translation: 生物流体样品分配到含有试剂的多孔基材上的测定通过将生物流体分配在两个或更多个部分中，通过分配生物流体不分配的间隔而提高了精度和重复性。 在不分配生物流体的间隔期间，可以分配试剂和其它流体。 或者，可以以类似的方式将试剂和其它流体分配到已经含有生物流体的基底上。
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3.发明申请公开(公告)号：US20100172801A1
公开(公告)日：2010-07-08
申请号：US12688346
申请日：2010-01-15
Applicant: Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
Inventor： Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
IPC: G01N30/00 , G01N33/487
CPC classification number: B01L3/502746 , B01L3/502723 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2400/0406 , B01L2400/0409 , B01L2400/0418 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , Y10T436/2575
Abstract: Analytical results obtained with microfluidic devices are improved by providing structural features in areas containing dry supported reagents, the structural features directing the flow of a sample over the area in a predetermined uniform manner and facilitating the purging of air.
Abstract translation: 通过在含有干支持试剂的区域中提供结构特征来改进用微流体装置获得的分析结果，其结构特征以预定均匀的方式引导样品流过该区域并促进空气吹扫。
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4.发明授权
公开(公告)号：US5290703A
公开(公告)日：1994-03-01
申请号：US990592
申请日：1992-12-14
Applicant: Chen-Jung Hsu , Robert C. Payne , James A. Profitt
Inventor： Chen-Jung Hsu , Robert C. Payne , James A. Profitt
CPC classification number: G01N1/405 , G01N33/491 , G01N33/92 , G01N2800/044 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
Abstract: A method for separating high density lipoproteins from blood serum or plasma. The method involves contacting the blood sample with an absorbant material comprising porous silica or silicate to adsorb the high density lipoprotein in preference to other lipoproteins in the blood sample. When combined with means for removing very low density lipoproteins and chylomicrons from the blood sample, the remaining low density lipoproteins can be measured directly.
Abstract translation: 从血清或血浆中分离高密度脂蛋白的方法。 该方法包括使血液样品与包含多孔二氧化硅或硅酸盐的吸收剂材料接触，以优先于血液样品中的其它脂蛋白吸附高密度脂蛋白。 当结合用于从血液样品中除去非常低密度脂蛋白和乳糜微粒的方法时，可以直接测量剩余的低密度脂蛋白。
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公开(公告)号：US4771069A
公开(公告)日：1988-09-13
申请号：US13519
申请日：1987-02-11
Applicant: Helen H. Ong , Vernon B. Anderson , James A. Profitt
Inventor： Helen H. Ong , Vernon B. Anderson , James A. Profitt
IPC: C07D337/14 , A61K31/38 , C07D409/12
CPC classification number: C07D337/14
Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.
Abstract translation: 公开了新型氨基烷基硫代二苯并硫蛋白及其相关化合物，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽用制剂以及通过施用方法进行治疗。 这些化合物可用作抗抑郁药，止痛剂和抗惊厥剂。
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Patent Agency Ranking
公开(公告)号：US4408050A
公开(公告)日：1983-10-04
申请号：US332178
申请日：1981-12-18
Applicant: Helen H. Ong , James A. Profitt
Inventor： Helen H. Ong , James A. Profitt
IPC: C07D211/64 , C07D471/10
CPC classification number: C07D471/10 , C07D211/64
Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.
Abstract translation: 描述了新的螺[二氢吲哚-3,4'-哌啶]和相关化合物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药和镇定剂。 还描述了制备二氢吲哚环的新方法。
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公开(公告)号：US4379933A
公开(公告)日：1983-04-12
申请号：US332175
申请日：1981-12-18
Applicant: Helen H. Ong , James A. Profitt
Inventor： Helen H. Ong , James A. Profitt
IPC: C07D211/64 , C07D471/10
CPC classification number: C07D471/10 , C07D211/64
Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.
Abstract translation: 描述了新的螺[二氢吲哚-3,4'-哌啶]和相关化合物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药和镇定剂。 还描述了制备二氢吲哚环的新方法。
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公开(公告)号：US4379932A
公开(公告)日：1983-04-12
申请号：US332174
申请日：1981-12-18
Applicant: Helen H. Ong , James A. Profitt
Inventor： Helen H. Ong , James A. Profitt
IPC: C07D211/64 , C07D471/10
CPC classification number: C07D471/10 , C07D211/64
Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.
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公开(公告)号：US09439630B2
公开(公告)日：2016-09-13
申请号：US12674944
申请日：2008-08-27
Applicant: Chris T. Zimmerle , Michael J. Pugia , James A. Profitt
Inventor： Chris T. Zimmerle , Michael J. Pugia , James A. Profitt
IPC: G01N33/543 , A61B10/00 , G01N33/558 , G01N35/00
CPC classification number: A61B10/007 , A61B90/90 , A61B90/96 , G01N33/558 , G01N35/00732 , G01N2035/00752 , G01N2035/00772
Abstract: Sample media for the analysis of analytes in a fluid test sample includes a carrier, at least one test field on the surface of the carrier including at least one reagent reactive with the analytes and capable of providing a detectable response. A non-visible bar code formed by at least two distinct non-visible marker fields is located on the carrier. The marker fields are configured to reflect electro-magnetic (EM) radiation within one or more ranges of non-visible wavelengths to form a coded sequence of reflectances correlated to identification of the sample media.
Abstract translation: 用于分析流体测试样品中的分析物的样品介质包括载体，载体表面上的至少一个测试场包括至少一种与分析物反应的试剂并且能够提供可检测的反应。 由至少两个不同的不可见标记字段形成的不可视条形码位于载体上。 标记场被配置为在不可见波长的一个或多个范围内反映电磁（EM）辐射，以形成与样本介质的识别相关的反射的编码序列。
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公开(公告)号：US08361782B2
公开(公告)日：2013-01-29
申请号：US12598141
申请日：2008-03-14
Applicant: Michael J. Pugia , James A. Profitt
Inventor： Michael J. Pugia , James A. Profitt
IPC: C12M1/36
CPC classification number: B01L3/502738 , B01L3/0268 , B01L3/50273 , B01L2200/0621 , B01L2300/0636 , B01L2300/0825 , B01L2400/0406 , B01L2400/0688 , B01L2400/086 , Y10T436/118339
Abstract: Assays in which samples of biological fluids are dispensed into the inlet port of a microfluidic device are improved in the accuracy and repeatability by dispensing the biological sample and/or associated liquids in small droplets and at timed intervals to control the operation of the microfluidic device.
Abstract translation: 通过以小液滴和定时的间隔分配生物样品和/或相关液体来控制微流体装置的操作，通过将生物流体的样品分配到微流体装置的入口端口的分析物的精度和重复性得到改善。
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