公开(公告)号：US09669200B2

公开(公告)日：2017-06-06

申请号：US13205039

申请日：2011-08-08

申请人： Natalie Ann Borgos ,  Tania M. Schroeder ,  David J. Yonce ,  Robert E. Lund ,  Suranajan Roychowdhury

发明人： Natalie Ann Borgos ,  Tania M. Schroeder ,  David J. Yonce ,  Robert E. Lund ,  Suranajan Roychowdhury

IPC分类号： A61F5/41 ,  A61M35/00

CPC分类号： A61M35/003 ,  A61F5/41 ,  A61F2005/411 ,  A61F2005/418

摘要： Systems and methods of localizing or delivery cells, biologics and/or drugs to a specific target area to treat pelvic health disorders are provided. A treatment composition including cells, biologics and/or drugs are associated with magnetic particulates, and the positioning of these materials is facilitated through use of a magnetic field-generating device that is configured to be placed on or into a pelvic anatomical structure. Certain embodiments directed to the treatment of ED in male patients can include a cell based therapy system.

公开(公告)号：US08364265B2

公开(公告)日：2013-01-29

申请号：US11620901

申请日：2007-01-08

申请人： David Ternes ,  David J. Yonce

发明人： David Ternes ,  David J. Yonce

IPC分类号： A61N1/368

CPC分类号： A61N1/3712 ,  A61N1/3627 ,  A61N1/3684

摘要： An apparatus and method for verifying capture by a pacing pulse in which a test depolarization waveform recorded during a pacing event is compared with a template waveform representing capture by the pacing pulse. Capture verification in this manner may be used in pacemakers having multiple pacing channels for the atrial and/or ventricles where the multiple paces can interfere with conventional sensing of evoked responses in order to verify capture.

公开(公告)号：US07751890B2

公开(公告)日：2010-07-06

申请号：US10890810

申请日：2004-07-14

申请人： Aaron McCabe ,  David J. Yonce

发明人： Aaron McCabe ,  David J. Yonce

IPC分类号： A61N1/00 ,  A61B5/04

CPC分类号： A61N1/3706 ,  A61N1/0504 ,  A61N1/3756

摘要： A self-diagnostic system for an implantable cardiac device such as a pacemaker, cardioverter, or resynchronization device which utilizes a subcutaneous ECG channel is described. The subcutaneous ECG channel allows the device to, in real time and independent of the standard pacing and sensing circuitry, verify the presence of pacing spikes, chamber senses, and other device outputs and hence establish and verify device integrity.

摘要翻译： 描述了一种用于可植入心脏装置的自我诊断系统，例如采用皮下ECG通道的起搏器，心律转复器或再同步装置。 皮下ECG通道允许器件实时且独立于标准起搏和感测电路，验证起搏尖峰，腔室感测和其他器件输出的存在，从而建立和验证器件的完整性。

公开(公告)号：US07583998B2

公开(公告)日：2009-09-01

申请号：US11157426

申请日：2005-06-21

申请人： Scott A. Meyer ,  David J. Yonce ,  David J. Ternes

发明人： Scott A. Meyer ,  David J. Yonce ,  David J. Ternes

IPC分类号： A61N1/37

CPC分类号： A61N1/368 ,  A61N1/3684 ,  A61N1/3712

摘要： Methods and systems involve multi-chamber cardiac capture detection utilizing sensing during a cross-chamber refractory period. First and second pacing pulses are delivered to first and second heart chamber. Capture or non-capture of the second heart chamber is determined. Sensing in the first heart chamber is performed to sense for cross-chamber propagation initiated by the second pacing pulse. Capture of the first chamber is detected if capture of the second heart chamber is detected and if the cross-chamber propagation is not detected.

摘要翻译： 方法和系统涉及在跨室不应期期间利用感测的多室心脏捕获检测。 第一和第二起搏脉冲被输送到第一和第二心室。 确定第二心室的捕获或非捕获。 执行在第一心室中的感测以感测由第二起搏脉冲发起的交叉腔传播。 如果检测到第二心室的捕获并且未检测到横隔室传播，则检测到第一腔室的捕获。

公开(公告)号：US07336998B2

公开(公告)日：2008-02-26

申请号：US10608825

申请日：2003-06-24

申请人： David J. Yonce

发明人： David J. Yonce

IPC分类号： A61N1/08 ,  A61B5/04

CPC分类号： A61B5/7264 ,  A61B5/0402 ,  A61N1/362

摘要： This document discusses, among other things, an external device capable of independently distinguishing between pace pulses delivered by an implantable cardiac rhythm management device to different locations of a subject's heart. In one example, polarity of the pace pulses is detected along two different electrocardiograph (ECG) vectors defined by three external skin electrodes. In a further example, the detection of a ventricular depolarization is also used to assign location information to pace pulses. In another example, characterizing information (e.g., polarity, amplitude, pulsewidth, time difference between a pace pulse and a corresponding heart depolarization) is used to classify pace pulses into distinct classes to which location information can be assigned. An ECG display/recorder of the external device is capable of annotating pace pulses or markers using the location information.

摘要翻译： 本文件尤其讨论了能够独立地区分由可植入心律管理装置传送的步速脉冲与被检者心脏的不同位置的外部装置。 在一个示例中，通过由三个外部皮肤电极限定的两个不同的心电图（ECG）矢量来检测起搏脉冲的极性。 在另一个例子中，心室去极化的检测也用于将位置信息分配给起搏脉冲。 在另一示例中，使用表征信息（例如，极性，幅度，脉冲宽度，步速脉冲和对应的心脏去极化之间的时间差）将步调脉冲分类为可以分配位置信息的不同类别。 外部设备的ECG显示/记录器能够使用位置信息注释步调脉冲或标记。

公开(公告)号：US07286876B2

公开(公告)日：2007-10-23

申请号：US10251629

申请日：2002-09-19

申请人： David J. Yonce ,  David Ternes

发明人： David J. Yonce ,  David Ternes

IPC分类号： A61N1/368

CPC分类号： A61B5/7264 ,  A61B5/04525 ,  A61B5/7203 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3712

摘要： An apparatus and method for verifying capture by first and second pacing pulses in which an evoked response waveform recorded during a pacing event is compared with template waveforms representing capture by the first, second, and both pacing pulses. The evoked response is then classified as representing a type of capture represented by a template waveform if the evoked response waveform highly correlates with one template waveform and has correlation values with the other template waveforms within specified bounds.

摘要翻译： 用于通过第一和第二起搏脉冲来验证捕获的装置和方法，其中在起搏事件期间记录的诱发响应波形与表示由第一，第二和两个起搏脉冲捕获的模板波形进行比较。 如果诱发响应波形与一个模板波形高度相关，并将诱发响应分类为表示由模板波形表示的捕获类型，并且与指定范围内的其他模板波形具有相关值。

公开(公告)号：US06950694B2

公开(公告)日：2005-09-27

申请号：US10321131

申请日：2002-12-17

申请人： David J. Yonce

发明人： David J. Yonce

IPC分类号： A61B5/0428 ,  A61B5/04

CPC分类号： A61B5/0428

摘要： A voltage sensing system includes input impedance balancing for electrocardiogram (ECG) sensing or other applications, providing immunity to common-mode noise signals while capable of use with two electrodes. Signals are received at first and second electrodes having associated impedances. An impedance circuit includes a feedback controller that adjusts an effective impedance associated with the second electrode based on a difference signal, a common mode signal, a phase-shifted (e.g., quadrature common mode) signal, and an impedance associated with the first electrode. As a result, signals associated with each electrode undergo a similar degree of gain/attenuation and/or phase-shift. This reduces common mode noise and enhances the signal-to-noise characteristics of a desired ECG or other output signal, without requiring the use of more than two electrodes.

摘要翻译： 电压感测系统包括用于心电图（ECG）感测或其他应用的输入阻抗平衡，为共模噪声信号提供抗扰性，同时能够与两个电极一起使用。 在具有相关阻抗的第一和第二电极处接收信号。 阻抗电路包括反馈控制器，其基于差分信号，共模信号，相移（例如，正交共模）信号和与第一电极相关联的阻抗来调节与第二电极相关联的有效阻抗。 结果，与每个电极相关联的信号经历相似程度的增益/衰减和/或相移。 这降低了共模噪声，并且增强了期望的ECG或其它输出信号的信噪比特性，而不需要使用两个以上的电极。

公开(公告)号：US06819953B2

公开(公告)日：2004-11-16

申请号：US10251310

申请日：2002-09-19

申请人： David J. Yonce ,  Peter John Ormsby

发明人： David J. Yonce ,  Peter John Ormsby

IPC分类号： A61B504

CPC分类号： A61B5/0428 ,  A61B5/7217

摘要： A system and method for detecting pacing pulses generated by a cardiac pacemaker within an ECG signal. The method involves decomposing the ECG signal into high and low-frequency components that represent the energy of the input signal in high and low-frequency bands. The timing of energy pulses detected within the high and low-frequency bands are then used to determine whether the pulses may represent a pacing pulse.

摘要翻译： 一种用于检测ECG信号内由心脏起搏器产生的起搏脉冲的系统和方法。 该方法包括将ECG信号分解成表示高频段和低频带中输入信号能量的高频和低频分量。 然后，使用在高频和低频带内检测到的能量脉冲的定时来确定脉冲是否可以表示起搏脉冲。

公开(公告)号：US06760624B2

公开(公告)日：2004-07-06

申请号：US10006457

申请日：2001-12-03

申请人： Russell E. Anderson ,  David J. Yonce

发明人： Russell E. Anderson ,  David J. Yonce

IPC分类号： A61N1375

CPC分类号： A61N1/36521 ,  A61N1/368

摘要： A method and apparatus for measuring the lead impedance of a medical lead used with an implantable medical stimulator which relies upon a count of the number of switching cycles of a switching converter power supply to replenish the energy delivered from an pacing capacitor in delivering a stimulating pulse to tissue.

摘要翻译： 一种用于测量与可植入医疗刺激器一起使用的医疗引线的引线阻抗的方法和装置，其依赖于开关转换器电源的开关周期数量的计数，以补充从起搏电容器输送的能量，以递送刺激脉冲 到组织。

公开(公告)号：US06208888B1

公开(公告)日：2001-03-27

申请号：US09243265

申请日：1999-02-03

申请人： David J. Yonce

发明人： David J. Yonce

IPC分类号： A61B504

CPC分类号： H03F3/45475 ,  A61B5/0428 ,  H03F3/45932 ,  H03F2200/261 ,  Y10S128/901 ,  Y10S128/902

摘要： A voltage sensing system includes input impedance balancing for electrocardiogram (ECG) sensing or other applications, providing immunity to common-mode noise signals while capable of use with two electrodes. Signals are received at first and second electrodes having associated impedances. An impedance circuit includes a feedback controller that adjusts an effective impedance associated with the second electrode based on a difference signal, a common mode signal, a phase-shifted (e.g., quadrature common mode) signal, and an impedance associated with the first electrode. As a result, signals associated with each electrode undergo a similar degree of gain/attenuation and/or phase-shift. This reduces common mode noise and enhances the signal-to-noise characteristics of a desired ECG or other output signal, without requiring the use of more than two electrodes.

摘要翻译： 电压感测系统包括用于心电图（ECG）感测或其他应用的输入阻抗平衡，为共模噪声信号提供抗扰性，同时能够与两个电极一起使用。 在具有相关阻抗的第一和第二电极处接收信号。 阻抗电路包括反馈控制器，其基于差分信号，共模信号，相移（例如，正交共模）信号和与第一电极相关联的阻抗来调节与第二电极相关联的有效阻抗。 结果，与每个电极相关联的信号经历相似程度的增益/衰减和/或相移。 这降低了共模噪声，并且增强了期望的ECG或其它输出信号的信噪比特性，而不需要使用两个以上的电极。