公开(公告)号：US20050256154A1

公开(公告)日：2005-11-17

申请号：US11110614

申请日：2005-04-20

申请人： Kin-Chun Luk ,  Lee McDermott ,  Pamela Rossman ,  Peter Wovkulich ,  Zhuming Zhang

发明人： Kin-Chun Luk ,  Lee McDermott ,  Pamela Rossman ,  Peter Wovkulich ,  Zhuming Zhang

IPC分类号： A61K31/4743 ,  C07D498/02

CPC分类号： C07D495/04

摘要： Disclosed are novel 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid amides, and their pharmaceutically acceptable salts and esters, that are selective inhibitors of KDR and/or FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular solid cancerous tumors of the breast, colon, lung and prostate. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer using these compounds.

摘要翻译： 公开了新的4-氨基 - 噻吩并[3,2-c]吡啶-7-羧酸酰胺及其药学上可接受的盐和酯，其是KDR和/或FGFR激酶的选择性抑制剂。 这些化合物及其药学上可接受的盐是可用于治疗或控制实体瘤，特别是乳腺，结肠，肺和前列腺的固体癌性肿瘤的抗增殖剂。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗癌症的方法。

公开(公告)号：US20050075272A1

公开(公告)日：2005-04-07

申请号：US10689235

申请日：2003-10-20

申请人： Apostolos Dermatakis ,  Marek Kabat ,  Kin-Chun Luk ,  Pamela Rossman ,  Sung-Sau So

发明人： Apostolos Dermatakis ,  Marek Kabat ,  Kin-Chun Luk ,  Pamela Rossman ,  Sung-Sau So

IPC分类号： A61P35/00 ,  C07D487/04 ,  A61K31/00

CPC分类号： C07D487/04 ,  G01N2800/52

摘要： Disclosed are novel pyrimido compounds that are selective inhibitors of both KDR and FGFR kinases and are selective against LCK. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer.

摘要翻译： 公开了作为KDR和FGFR激酶的选择性抑制剂的新的嘧啶化合物，并且对LCK具有选择性。 这些化合物及其药学上可接受的盐是可用于治疗或控制实体瘤，特别是乳腺癌，结肠癌，肺癌和前列腺肿瘤的抗增殖剂。 还公开了含有这些化合物的药物组合物和治疗癌症的方法。

公开(公告)号：US06307056B1

公开(公告)日：2001-10-23

申请号：US09464466

申请日：1999-12-15

申请人： Wendy Lea Corbett ,  Kin-Chun Luk ,  Paige E. Mahaney

发明人： Wendy Lea Corbett ,  Kin-Chun Luk ,  Paige E. Mahaney

IPC分类号： C07D40302

CPC分类号： C07D409/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14

摘要： Disclosed are 4-aryloxindoles that inhibit or modulate protein kinases, in particular JNK protein kinases. These compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are useful as anti-inflammatory agents, particularly useful in the treatment of rheumatoid arthritis. Also disclosed are pharmaceutical compositions containing the foregoing compounds, as well as methods for the treatment and/or control of inflammation, particularly in the treatment or control of rheumatoid arthritis, using said compounds.

摘要翻译： 公开了抑制或调节蛋白激酶，特别是JNK蛋白激酶的4-芳氧基吲哚。 这些化合物及其药学上可接受的盐和所述化合物的前药可用作抗炎剂，特别可用于治疗类风湿性关节炎。 还公开了含有前述化合物的药物组合物，以及使用所述化合物治疗和/或控制炎症，特别是治疗或控制类风湿性关节炎的方法。