公开(公告)号：US20100063412A1

公开(公告)日：2010-03-11

申请号：US12621984

申请日：2009-11-19

申请人： Andres Belalcazar

发明人： Andres Belalcazar

IPC分类号： A61B5/053

CPC分类号： A61B5/0537 ,  A61B5/4869

摘要： An amount of fluid in a thoracic or other region of a subject may be monitored by internally injecting an electrical energy stimulus (e.g., constant voltage source) through the region, detecting voltage resulting from the electrical energy stimulus, and calculating a fluid volume indicative signal. The injected energy stimulus creates a first lead field. The responsive voltage is detected using an electrode configuration that defines a second lead field, which is arranged in a negative sensitivity configuration with respect to the first lead field at the region being monitored.

摘要翻译： 可以通过在该区域内部注入电能刺激（例如，恒定电压源）来检测受试者的胸部或其他区域中的流体的量，检测由电能刺激产生的电压，以及计算流体体积指示信号 。 注入能量刺激产生了第一个引线场。 使用限定第二引线场的电极配置来检测响应电压，该引线场在被监视的区域处相对于第一引线场布置成负的灵敏度配置。

公开(公告)号：US20090012416A1

公开(公告)日：2009-01-08

申请号：US11772352

申请日：2007-07-02

申请人： Andres Belalcazar ,  Aaron Lewicke

发明人： Andres Belalcazar ,  Aaron Lewicke

IPC分类号： A61B5/085

CPC分类号： A61N1/3702 ,  A61B5/0031 ,  A61B5/0402 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/087 ,  A61B5/1116 ,  A61B5/416 ,  A61B5/4839 ,  A61B5/4878 ,  A61B5/686 ,  A61B5/7285 ,  A61B2560/0468 ,  A61N1/3627 ,  A61N1/36521 ,  G06F19/00

摘要： This patent document describes, among other things, systems and methods for monitoring lung fluid status, such as monitoring the presence or absence of pulmonary edema, in a subject using information about the cardiac impedance-indicating component of a measured impedance-indicating signal. In various examples, an amplitude or contribution change over multiple cardiac cycles of the cardiac impedance-indicating component is used to compute and provide a lung status indication. In various examples, a decreasing amplitude or contribution trend of the cardiac impedance-indicating component signifies an increasing amount of fluid in the subject's lungs, as a greater portion of an injected thoracic impedance measurement current formerly traversing the heart is rerouted through the lung due to the less resistance path created by the fluid accumulation therein. In another example, measurements of the impedance-indicating signal, and thus the cardiac impedance-indicating component, are taken at one or a combination of end-inspiration or end-expiration.

摘要翻译： 该专利文献尤其描述了使用关于所测量的阻抗指示信号的心脏阻抗指示部件的信息来监测受试者肺部流体状况的系统和方法，例如监测受试者是否存在肺水肿。 在各种示例中，使用心脏阻抗指示组件的多个心动周期的幅度或贡献变化来计算并提供肺状态指示。 在各种示例中，心脏阻抗指示组件的幅度或贡献趋势的减小表示受试者的肺中流体的量增加，因为原先穿过心脏的注射的胸部阻抗测量电流的较大部分通过肺被重新路由，因为 由其中积聚的液体产生的阻力路径越小。 在另一个示例中，阻抗指示信号的测量以及因此的心脏阻抗指示组件的测量以一个或结束吸气或终止呼气的组合进行。

公开(公告)号：US20080114407A1

公开(公告)日：2008-05-15

申请号：US11615383

申请日：2006-12-22

申请人： Joseph M. Pastore ,  Rodney W. Salo ,  Julio C. Spinelli ,  Allan C. Shuros ,  Andres Belalcazar

发明人： Joseph M. Pastore ,  Rodney W. Salo ,  Julio C. Spinelli ,  Allan C. Shuros ,  Andres Belalcazar

IPC分类号： A61N1/05

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/3688

摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.

摘要翻译： 用于输送心室起搏的可植入起搏装置可以被配置为间歇地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。 通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式 。 取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。