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公开(公告)号：US5836976A
公开(公告)日：1998-11-17
申请号：US846747
申请日：1997-04-30
申请人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
发明人： Xiaoyi Min , Li Wang , Rahul Mehra , Paul J. DeGroot , Walter H. Olson , Luc R. Mongeon , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3925 , A61N1/3987
摘要： In an implantable pacemaker/cardioverter/defibrillator, a system for correlating the delivery of a cardioversion therapy to an optimum point or phase of the respiratory cycle of the patient to effect delivery of the therapy when the impedance between the cardioversion electrodes is minimized. In a first application for use with cardioversion electrodes located substantially in contact with the heart chamber, the optimum point or phase is at the end of inspiration. In a second application for use with at least one cardioversion electrode located remotely from the heart chamber, the optimum point or phase is at end expiration or beginning of inspiration. The cardioversion therapy is delivered in synchrony with a ventricular sense event, if present. If the optimum point or phase of the respiratory cycle cannot be determined during a therapy time, a pre-shock may be delivered to elicit a respiration cycle through a stimulated contraction of the diaphragm.
摘要翻译： 在植入式心脏起搏器/心律转复除颤器中，用于将心脏复律治疗的输送与患者呼吸周期的最佳点或阶段相关联的系统，以在心脏复律电极之间的阻抗最小化时实现治疗的传递。 在与基本上与心脏腔室接触的心脏复律电极一起使用的第一个应用中，最佳点或阶段在吸气结束时。 在与远离心脏室的位置的至少一个心脏复律电极一起使用的第二个应用中，最佳点或阶段是结束期满或开始吸气。 复发疗法与心室感觉事件（如果存在）同步传递。 如果在治疗时间内不能确定呼吸周期的最佳点或相位，则可以传送预休克以通过振膜的刺激收缩引起呼吸循环。
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公开(公告)号：US5713924A
公开(公告)日：1998-02-03
申请号：US495251
申请日：1995-06-27
申请人： Xiaoyi Min , Luc R. Mongeon , Michael R. S. Hill
发明人： Xiaoyi Min , Luc R. Mongeon , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/395
摘要： A method an apparatus for treating fibrillation, particularly atrial fibrillation. In response to detection of fibrillation, a high frequency, low energy pulse burst is delivered via pacing electrodes, accompanied by a high energy pulse delivered via defibrillation electrodes. The low energy pulse burst is preferably delivered to an area of the heart which exhibits relatively lower current density during delivery of the high energy pulse.
摘要翻译： 一种用于治疗纤维性颤动，特别是心房颤动的装置的方法。 响应于原纤维的检测，通过起搏电极输送高频，低能脉冲脉冲，伴随着通过除颤电极传送的高能量脉冲。 低能量脉冲脉冲优选地被传送到在高能量脉冲传送期间呈现相对较低的电流密度的心脏区域。
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公开(公告)号：US09656079B2
公开(公告)日：2017-05-23
申请号：US12565910
申请日：2009-09-24
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.
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44.发明授权Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure 有权在医疗过程之前和期间神经刺激和心脏感知的方法和系统公开(公告)号：US08036741B2
公开(公告)日：2011-10-11
申请号：US12557950
申请日：2009-09-11
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/36114 , A61N1/362 , A61N1/36514 , A61N1/385 , A61N1/39
摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. A sensor to sense a characteristic of a fluid or tissue, such as an impending contraction, may be also used during the medical procedure. Systems and devices for performing the medical procedure are also provided.
摘要翻译： 提供了一种执行诸如手术的医疗程序的方法。 刺激神经以将心脏的跳动调节到第一状态，例如停止或减缓的状态。 医疗程序在心脏或另一个器官上进行。 停止对神经的刺激，以便将心脏的跳动调节到第二状态，例如打浆状态。 心脏本身也可能被刺激到跳动状态，例如通过起搏。 可以继续刺激神经以允许继续医疗程序。 也可以在医疗过程中使用用于感测流体或组织的特征的传感器，例如即将收缩的收缩。 还提供用于执行医疗程序的系统和设备。
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公开(公告)号：US07650190B2
公开(公告)日：2010-01-19
申请号：US11751813
申请日：2007-05-22
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7-L2 and the associated neural fibers within a region of the T7-L2 dermatomes.
摘要翻译： 提供了一种通过激素调节进行矫正治疗的方法和装置。 通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。 本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。 电刺激部位包括但不限于在T7-L2皮层区域内的T7-L2级和相关神经纤维的脊髓。
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46.发明授权公开(公告)号：US07225019B2
公开(公告)日：2007-05-29
申请号：US10724978
申请日：2003-12-01
IPC分类号： A61N1/362
CPC分类号： A61N1/36017 , A61N1/36114 , A61N1/385
摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. A sensor to sense a characteristic of a fluid or tissue, such as an impending contraction, may be also used during the medical procedure. Systems and devices for performing the medical procedure are also provided.
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47.发明授权Method and system for nerve stimulation prior to and during a medical procedure 有权在医疗过程之前和期间神经刺激的方法和系统公开(公告)号：US07184829B2
公开(公告)日：2007-02-27
申请号：US10768999
申请日：2004-01-30
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/056 , A61N1/362 , A61N1/36514 , A61N1/37288 , A61N1/385 , A61N1/39
摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. Systems and devices for performing the medical procedure are also provided.
摘要翻译： 提供了一种执行诸如手术的医疗程序的方法。 刺激神经以将心脏的跳动调节到第一状态，例如停止或减缓的状态。 医疗程序在心脏或另一个器官上进行。 停止对神经的刺激，以便将心脏的跳动调节到第二状态，例如打浆状态。 心脏本身也可能被刺激到跳动状态，例如通过起搏。 可以继续刺激神经以允许继续医疗程序。 还提供用于执行医疗程序的系统和设备。
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48.发明授权Method and system for spinal cord stimulation prior to and during a medical procedure 有权在医疗过程之前和期间脊髓刺激的方法和系统公开(公告)号：US07184828B2
公开(公告)日：2007-02-27
申请号：US10716810
申请日：2003-11-19
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61N1/36021 , A61N1/3625 , A61N1/385
摘要： A method of performing a medical procedure, such as surgery, is provided. The spinal cord is stimulated in order to control at least one physiological function. The medical procedure is performed and stimulation of the spinal cord is stopped.
摘要翻译： 提供了一种执行诸如手术的医疗程序的方法。 刺激脊髓以控制至少一种生理功能。 执行医疗程序并停止对脊髓的刺激。
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49.发明授权公开(公告)号：US06912419B2
公开(公告)日：2005-06-28
申请号：US10387280
申请日：2003-03-12
IPC分类号： A61B17/00 , A61B17/02 , A61B17/34 , A61N1/05 , A61N1/36 , A61N1/362 , A61N1/38 , A61N1/39 , A61N1/18
CPC分类号： A61N1/36114 , A61B17/3417 , A61B2017/00243 , A61B2017/00969 , A61B2017/0243 , A61B2017/3445 , A61B2017/3449 , A61N1/056 , A61N1/362 , A61N1/385 , A61N1/3962
摘要： An electro-stimulation device includes a pair of electrodes for connection to at least one location in the body that affects or regulates the heartbeat. The electro-stimulation device both electrically arrests the heartbeat and stimulates the heartbeat. A pair of electrodes are provided for connection to at least one location in the body that affects or regulates the heartbeat. The pair of electrodes may be connected to an intravenous catheter for transvenous stimulation of the appropriate nerve. A first switch is connected between a power supply and the electrodes for selectively supplying current from the power supply to the electrodes to augment any natural stimuli to the heart and thereby stop the heart from beating. A second switch is connected between the power supply and the electrodes for selectively supplying current from the power supply to the electrodes to provide an artificial stimulus to initiate heartbeating. In another aspect, the invention is directed to a method for arresting the beat of a heart in a living body comprising the steps of connecting the pair of electrodes to at least one location in the body that affects or regulates the heartbeat and supplying an electrical current to the electrodes of sufficient amplitude and duration to arrest the heartbeat. The device may also serve to still the lungs by input to a respirator or by stimulation of the phrenic nerve during surgical procedures.
摘要翻译： 电刺激装置包括一对电极，用于连接到体内至少一个影响或调节心跳的位置。 电刺激装置既电气阻止心跳并刺激心跳。 提供一对电极用于连接到体内至少一个影响或调节心跳的位置。 该对电极可以连接到静脉导管，用于适当神经的经静脉刺激。 第一开关连接在电源和电极之间，用于选择性地从电源向电极提供电流，以增加对心脏的任何自然刺激，从而阻止心脏跳动。 第二开关连接在电源和电极之间，用于选择性地从电源向电极提供电流以提供人造刺激以启动心跳。 另一方面，本发明涉及一种用于在生物体中阻止心脏的搏动的方法，包括以下步骤：将一对电极连接到体内至少一个位置，其影响或调节心跳并提供电流 到足够的幅度和持续时间的电极以阻止心跳。 该装置还可以通过输入呼吸器或在外科手术期间刺激膈神经而服用于肺。
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50.再颁专利公开(公告)号：USRE38705E1
公开(公告)日：2005-02-22
申请号：US10004182
申请日：2001-11-15
CPC分类号： A61N1/36114 , A61N1/056 , A61N1/362 , A61N1/385 , A61N1/3956
摘要： An electro-stimulation device includes a pair of electrodes for connection to at least one location in the body that affects or regulates the heartbeat. The electro-stimulation device both electrically arrests the heartbeat and stimulates the heartbeat. A pair of electrodes are provided for connection to at least one location in the body that affects or regulates the heartbeat. The pair of electrodes may be connected to an intravenous catheter for transvenous stimulation of the appropriate nerve. A first switch is connected between a power supply and the electrodes for selectively supplying current from the power supply to the electrodes to augment any natural stimuli to the heart and thereby stop the heart from beating. A second switch is connected between the power supply and the electrodes for selectively supplying current from the power supply to the electrodes to provide an artificial stimulus to initiate heartbeating. In another aspect, the invention is directed to a method for arresting the beat of a heart in a living body comprising the steps of connecting the pair of electrodes to at least one location in the body that affects or regulates the heartbeat and supplying an electrical current to the electrodes of sufficient amplitude and duration to arrest the heartbeat. The device may also serve to still the lungs by input to a respirator or by stimulation of the phrenic nerve during surgical procedures.
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