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49 条记录 (耗时 0.032 秒)

    Novel azacyclic ethynyl derivatives
    42.
    发明申请
    Novel azacyclic ethynyl derivatives 失效
    新型氮杂环乙炔衍生物

    公开(公告)号：US20080188519A1

    公开(公告)日：2008-08-07

    申请号：US12076929

    申请日：2008-03-25

    申请人： Dan Peters ,  Gurmar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Philip K. Ahring

    发明人： Dan Peters ,  Gurmar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Philip K. Ahring

    IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P3/00 ,  A61P25/00

    CPC分类号： C07D451/02 ,  C07D211/70 ,  C07D453/02

    摘要： Azacyclic ethynyl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 在烟碱乙酰胆碱受体和单胺受体和转运蛋白的调节剂中发现其是胆碱能配体的偶氮环乙炔衍生物。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    2,5-diazabicyclo[2.2.1]heptane derivatives
    46.
    发明授权
    2,5-diazabicyclo[2.2.1]heptane derivatives 失效
    2,5-二氮杂双环[2.2.1]庚烷衍生物

    公开(公告)号：US07329754B2

    公开(公告)日：2008-02-12

    申请号：US10250765

    申请日：2002-02-28

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Philip K. Ahring ,  Tino Dyhring Jorgensen

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Philip K. Ahring ,  Tino Dyhring Jorgensen

    IPC分类号： C07D215/38 ,  C07D265/30

    CPC分类号： C07D487/08 ,  A61K31/4995

    摘要： The present invention relates to novel 2,5-diazabicyclo[2.2.1]heptane derivatives, which are found to be potent modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的2,5-二氮杂双环[2.2.1]庚烷衍生物，其被发现是单胺受体和转运蛋白的有效调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Cation conducting GABAA receptors and their use
    47.
    发明授权
    Cation conducting GABAA receptors and their use 有权
    阳离子进行GABA A受体及其用途

    公开(公告)号：US07282344B2

    公开(公告)日：2007-10-16

    申请号：US10479251

    申请日：2002-06-04

    申请人： Marianne Lerbech Jensen ,  Philip K. Ahring ,  Thomas Varming

    发明人： Marianne Lerbech Jensen ,  Philip K. Ahring ,  Thomas Varming

    IPC分类号： C07K14/705 ,  G01N33/53 ,  G01N33/60

    CPC分类号： C07K14/70571

    摘要： This invention relates to cation conducting GABAA receptors, mutated GABAA receptor subunits, polynucleotide sequences encoding mutated subunits, expression vectors comprising the mutated subunits, host cells capable of expressing the mutated subunits, drug screening methods, and chemical substances identified by the drug screening methods of the invention.

    摘要翻译： 本发明涉及阳离子导电GABA A A受体，突变GABA A受体亚基，编码突变亚基的多核苷酸序列，包含突变亚基的表达载体，能够表达突变的亚基的宿主细胞 亚单位，药物筛选方法和通过本发明的药物筛选方法鉴定的化学物质。

    Diazabicyclic biaryl derivatives
    48.
    发明授权
    Diazabicyclic biaryl derivatives 失效
    二氮杂双环联芳基衍生物

    公开(公告)号：US07223753B2

    公开(公告)日：2007-05-29

    申请号：US10703556

    申请日：2003-11-10

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Oestergaard Nielsen ,  Tino Dyhring Joergensen ,  Philip K. Ahring

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Oestergaard Nielsen ,  Tino Dyhring Joergensen ,  Philip K. Ahring

    IPC分类号： A61P25/00 ,  A61K31/551 ,  A61K31/495 ,  C07D471/00 ,  C07D243/00

    CPC分类号： C07D471/08 ,  A61K31/551 ,  C07D487/08

    摘要： This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的二氮杂双环联芳基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Heteroaryl-diazabicycloalkanes
    49.
    发明授权
    Heteroaryl-diazabicycloalkanes 失效
    杂芳基 - 二氮杂双环烷烃

    公开(公告)号：US06815438B2

    公开(公告)日：2004-11-09

    申请号：US10130099

    申请日：2002-05-14

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Philip K. Ahring ,  Simon Feldbaek Nielsen ,  Tino Dyhring Jorgensen

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Philip K. Ahring ,  Simon Feldbaek Nielsen ,  Tino Dyhring Jorgensen

    IPC分类号： A61K3133

    CPC分类号： C07D471/08 ,  C07D487/04 ,  C07D487/08

    摘要： The present invention relates to novel heteroaryl-diazabicycloalkanes which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及在烟碱乙酰胆碱受体中被发现是胆碱能配体的新型杂芳基 - 二氮杂双环烷烃。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS）的胆碱能系统有关的疾病或病症，与平滑肌收缩相关的疾病或病症，内分泌疾病或 与神经变性相关的疾病，疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。