公开(公告)号：US20070292357A1

公开(公告)日：2007-12-20

申请号：US11880007

申请日：2007-07-19

申请人： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

发明人： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

IPC分类号： A61K31/445 ,  A61K31/56 ,  A61K9/12 ,  A61P11/00 ,  A61P11/08

CPC分类号： C07D211/62 ,  A61K9/124 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/12

摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：US20070292356A1

公开(公告)日：2007-12-20

申请号：US11880002

申请日：2007-07-19

申请人： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

发明人： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

IPC分类号： A61K31/445 ,  A61K31/56 ,  A61K9/12 ,  A61P11/00

CPC分类号： C07D211/62 ,  A61K9/124 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/12

摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：US20070265305A1

公开(公告)日：2007-11-15

申请号：US11879996

申请日：2007-07-19

申请人： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

发明人： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

IPC分类号： A61K31/445 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08

CPC分类号： C07D211/62 ,  A61K9/124 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/12

摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：US07262205B2

公开(公告)日：2007-08-28

申请号：US11077345

申请日：2005-03-10

申请人： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Eric L. Stangeland ,  Aaron Kushner ,  Craig Husfeld

发明人： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Eric L. Stangeland ,  Aaron Kushner ,  Craig Husfeld

IPC分类号： A61K31/445 ,  C07D211/04 ,  C07D401/12

CPC分类号： C07D211/62 ,  C07D211/60

摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：US20060205775A1

公开(公告)日：2006-09-14

申请号：US11371512

申请日：2006-03-09

申请人： Yu-Hua Ji ,  Craig Husfeld ,  Li Li ,  Mathai Mammen ,  YongQi Mu ,  Eric Stangeland

发明人： Yu-Hua Ji ,  Craig Husfeld ,  Li Li ,  Mathai Mammen ,  YongQi Mu ,  Eric Stangeland

IPC分类号： A61K31/4545 ,  A61K31/454 ,  C07D401/02 ,  C07D403/02

CPC分类号： C07D405/14 ,  C07D211/62 ,  C07D401/12 ,  C07D409/14

摘要： The invention provides compounds of formula I: wherein a, b, c, d, n, R1, R2, R3, R6, R7, W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

摘要翻译： 本发明提供式I化合物：其中a，b，c，d，n，R 1，R 2，R 3，R 7，R 7，W和A如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US20050026954A1

公开(公告)日：2005-02-03

申请号：US10888855

申请日：2004-07-09

申请人： Mathai Mammen ,  Richard Wilson ,  Sarah Dunham ,  Adam Hughes ,  Craig Husfeld ,  Yu-Hua Ji ,  Li Li ,  Trevor Mischki ,  Ioanna Stergiades ,  David Oare

发明人： Mathai Mammen ,  Richard Wilson ,  Sarah Dunham ,  Adam Hughes ,  Craig Husfeld ,  Yu-Hua Ji ,  Li Li ,  Trevor Mischki ,  Ioanna Stergiades ,  David Oare

IPC分类号： A61P13/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07 ,  A61K31/454 ,  A61K31/4545

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14

摘要： This invention provides 4-amino-1-benzylpiperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome, asthma and chronic obstructive pulmonary disease, using such compounds.

摘要翻译： 本发明提供了可用作毒蕈碱受体拮抗剂的4-氨基-1-苄基哌啶及其相关化合物及其药学上可接受的盐。 本发明还提供含有这些化合物的药物组合物; 用于制备这些化合物的方法和中间体; 以及使用这些化合物治疗由毒蕈碱受体介导的疾病状态如膀胱过度活动症，肠易激综合征，哮喘和慢性阻塞性肺病的方法。

公开(公告)号：US07858797B2

公开(公告)日：2010-12-28

申请号：US12272070

申请日：2008-11-17

申请人： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu

发明人： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu

IPC分类号： C07D401/02 ,  A61K31/4439

CPC分类号： C07D211/62

摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，r，R1，R2，R3，R4，R5，R6，R7和W如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US20100125079A1

公开(公告)日：2010-05-20

申请号：US12693105

申请日：2010-01-25

申请人： YongQi Mu ,  Yu-Hua Ji ,  Mathai Mammen ,  Viengkham Malathong

发明人： YongQi Mu ,  Yu-Hua Ji ,  Mathai Mammen ,  Viengkham Malathong

IPC分类号： A61K31/496 ,  C07D211/94 ,  A61K31/445 ,  C07D409/12 ,  A61K31/4535 ,  A61P11/00 ,  A61P21/00 ,  A61P25/00 ,  C07D405/12 ,  C07D401/12 ,  C07D401/14 ,  A61K31/4545

CPC分类号： C07D401/12 ,  C07D211/46 ,  C07D211/62 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12

摘要： The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

摘要翻译： 本发明提供式I化合物：其中a，b，c，m，n，q，r，w，Z1，Ar1，Z2，Y，R1，R2和R3如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US07569586B2

公开(公告)日：2009-08-04

申请号：US11204263

申请日：2005-08-15

申请人： Mathai Mammen ,  Trevor Mischki ,  Adam Hughes ,  Yu-Hua Ji

发明人： Mathai Mammen ,  Trevor Mischki ,  Adam Hughes ,  Yu-Hua Ji

IPC分类号： A61K31/445

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14

摘要： This invention provides compounds of formula I: wherein R1, R2, R3, R4,R5, R6, R7, R8a, R8b, W, a, b, c and m are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity. Accordingly, such compounds are expected to be useful as therapeutic agents for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

摘要翻译： 本发明提供了式I的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8a，R 8b，W，a，b，c和m如本说明书中所定义，或其药学上可接受的盐或溶剂合物 或其立体异构体。 本发明的化合物具有β2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性。 因此，预期这些化合物可用作治疗肺部疾病如慢性阻塞性肺疾病和哮喘的治疗剂。

公开(公告)号：US07151115B2

公开(公告)日：2006-12-19

申请号：US11337451

申请日：2006-01-23

申请人： Mathai Mammen ,  Yu-Hua Ji ,  Sarah Dunham ,  Li Li

发明人： Mathai Mammen ,  Yu-Hua Ji ,  Sarah Dunham ,  Li Li

IPC分类号： A61K31/40 ,  A61K31/445

CPC分类号： C07D403/12 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K31/40 ,  A61K31/445 ,  C07D207/09

摘要： This invention provides compounds of formula I: wherein a, b, c, e, m, R1, R2, R3, R4a, R4b, R5, R6, R7 and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.