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公开(公告)号：US07851631B2
公开(公告)日：2010-12-14
申请号：US11879829
申请日：2007-07-19
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Eric L. Stangeland , Aaron Kushner , Craig Husfeld
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Eric L. Stangeland , Aaron Kushner , Craig Husfeld
IPC分类号： C07D401/12 , A61K31/454
CPC分类号： C07D211/62 , C07D211/60
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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公开(公告)号：US07262205B2
公开(公告)日：2007-08-28
申请号：US11077345
申请日：2005-03-10
申请人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Eric L. Stangeland , Aaron Kushner , Craig Husfeld
发明人： Mathai Mammen , Yu-Hua Ji , YongQi Mu , Eric L. Stangeland , Aaron Kushner , Craig Husfeld
IPC分类号： A61K31/445 , C07D211/04 , C07D401/12
CPC分类号： C07D211/62 , C07D211/60
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
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公开(公告)号：US20100137325A1
公开(公告)日：2010-06-03
申请号：US12699539
申请日：2010-02-03
申请人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
发明人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
IPC分类号： A61K31/498 , C07D401/06 , A61K31/454 , C07D401/14 , A61P9/00
CPC分类号： C07D211/58 , C07D211/46 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D487/08 , C07D487/10
摘要： The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，f，W，Q，Y，R 1，R 2和R 3如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US07479562B2
公开(公告)日：2009-01-20
申请号：US11372251
申请日：2006-03-09
申请人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
发明人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
IPC分类号： C07D211/00 , C07D409/00 , C07D405/00
CPC分类号： C07D211/58 , C07D211/46 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D487/08 , C07D487/10
摘要： The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，f，W，Q，Y，R 1，R 2和R 3如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US07683173B2
公开(公告)日：2010-03-23
申请号：US12265091
申请日：2008-11-05
申请人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
发明人： Yu-Hua Ji , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
IPC分类号： C07D211/02 , C07D409/00 , C07D405/00
CPC分类号： C07D211/58 , C07D211/46 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D487/08 , C07D487/10
摘要： The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，f，W，Q，Y，R 1，R 2和R 3如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20100041701A1
公开(公告)日：2010-02-18
申请号：US12582865
申请日：2009-10-21
申请人： Yu-Hua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric L. Stangeland
发明人： Yu-Hua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric L. Stangeland
IPC分类号： A61K31/4545 , C07D211/94 , C07D401/14 , A61K31/454 , A61P9/10
CPC分类号： C07D405/14 , C07D211/62 , C07D401/12 , C07D409/14
摘要： The invention provides compounds of formula I: wherein a, b, c, d, n, R1, R2, R3, R6, R7, W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，n，R 1，R 2，R 3，R 6，R 7，W和A如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US07629336B2
公开(公告)日：2009-12-08
申请号：US11371512
申请日：2006-03-09
申请人： Yu-Hua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric L. Stangeland
发明人： Yu-Hua Ji , Craig Husfeld , Li Li , Mathai Mammen , YongQi Mu , Eric L. Stangeland
IPC分类号： C07D211/44 , C07D401/10 , C07D401/12 , A61K31/435
CPC分类号： C07D405/14 , C07D211/62 , C07D401/12 , C07D409/14
摘要： The invention provides compounds of formula I: wherein a, b, c, d, n, R1, R2, R3, R6, R7, W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，n，R 1，R 2，R 3，R 6，R 7，W和A如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20090076026A1
公开(公告)日：2009-03-19
申请号：US12265091
申请日：2008-11-05
申请人： Yu-Hua JI , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
发明人： Yu-Hua JI , Craig Husfeld , Mathai Mammen , YongQi Mu , Eric L. Stangeland
IPC分类号： A61K31/496 , C07D401/02 , C07D211/32 , A61K31/4545 , A61K31/445 , A61P9/00 , A61P11/06 , A61K31/454 , C07D211/36 , C07D211/56
CPC分类号： C07D211/58 , C07D211/46 , C07D211/62 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D487/08 , C07D487/10
摘要： The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，f，W，Q，Y，R 1，R 2和R 3如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US08067439B2
公开(公告)日：2011-11-29
申请号：US12938539
申请日：2010-11-03
申请人： Mathai Mammen , YuHua Ji , YongQi Mu , Eric L. Stangeland , Aaron Kushner , Craig Husfeld
发明人： Mathai Mammen , YuHua Ji , YongQi Mu , Eric L. Stangeland , Aaron Kushner , Craig Husfeld
IPC分类号： C07D401/12 , A61K31/4465 , A61K31/4523
CPC分类号： C07D211/62 , C07D211/60
摘要： This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，d，m，n，p，r，R1，R2，R3，R4，R5，R6，R7和W如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号：US20060281740A1
公开(公告)日：2006-12-14
申请号：US11451179
申请日：2006-06-12
申请人： Yu-Hua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
发明人： Yu-Hua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
IPC分类号： C07D417/02 , C07D413/02 , C07D401/02 , C07D403/02 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/454
CPC分类号： C07D211/46 , C07D405/12 , C07D409/12 , C07D487/08
摘要： The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译： 本发明提供式I化合物：其中a，b，c，m，s，t，w，Z，Ar，R 1，R 2， > 3 ，R 6和R 7如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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