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41.发明授权Process for producing peptides with side chains containing imidazolinylamino, tetrahydropyrimidinylamino, or alkylguanidinyl groups 失效用于产生含有咪唑啉基氨基，四氢嘧啶基氨基或烷基胍基的侧链的肽的方法
公开(公告)号：US5432263A
公开(公告)日：1995-07-11
申请号：US188293
申请日：1994-01-28
CPC分类号： C07K1/1075
摘要： The present invention provides a process for the preparation of peptides which have or side-chains containing an alkyl- or dialkyl-substituted guanidinyl group or a imidazinylamino or tetrahydropyrimidinylamino group. The process provides higher overall yields of peptide product by permitting the synthesis of the entire peptide chain prior to modification of the side-chain to introduce the groups.
摘要翻译： 本发明提供了制备具有或含有烷基或二烷基取代的胍基基或咪唑啉基氨基或四氢嘧啶基氨基的侧链的肽的方法。 该方法通过允许在侧链修饰之前合成整个肽链以引入基团来提供更高的肽产物总产率。
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公开(公告)号：US5140009A
公开(公告)日：1992-08-18
申请号：US548511
申请日：1990-07-10
摘要： The present invention relates to novel LHRH analogs. The LHRH analogs include "pseudo" hexapeptide, heptapeptide, octapeptide and nonapeptide analogs of LHRH, wherein all or some of the amino acids, 1, 2 and 3 have been eliminated and the remaining (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) peptide is linked to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH.
摘要翻译： 本发明涉及新的LHRH类似物。 LHRH类似物包括LHRH的“假”六肽，七肽，八肽和非肽类似物，其中所有或一些氨基酸1,2和3已被消除，剩余的（2-9），（2-10）， （3-9），（3-10），（4-9）或（4-10）肽与代替LHRH中的氨基酸1,2或3的各种羧酸连接。
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公开(公告)号：US5110904A
公开(公告)日：1992-05-05
申请号：US548512
申请日：1990-07-10
申请人： Fortuna Haviv , Jonathan Greer
发明人： Fortuna Haviv , Jonathan Greer
摘要： The present invention relates to novel "pseudo" nonapeptide and decapeptide derivatives of LHRH. More particularly the present invention relates to derivatives of LHRH wherein the nitrogen atom of at least one of the amide bonds has been alkylated.
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公开(公告)号：US4226806A
公开(公告)日：1980-10-07
申请号：US1559
申请日：1979-01-08
申请人： Fortuna Haviv , Abraham Patchornik
发明人： Fortuna Haviv , Abraham Patchornik
IPC分类号： C07C309/24 , C07D501/20 , C07C143/52 , C07C143/525
CPC分类号： C07C309/24
摘要： Novel cephalosporin compounds of the following formula are useful as antibiotic agents: ##STR1##
摘要翻译： 下列配方的新型头孢菌素化合物可用作抗生素：
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公开(公告)号：US4093802A
公开(公告)日：1978-06-06
申请号：US759276
申请日：1977-01-14
申请人： Fortuna Haviv , Abraham Patchornik , Janina Altman
发明人： Fortuna Haviv , Abraham Patchornik , Janina Altman
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07C57/58 , C07C57/76 , C07D295/21 , C07D333/24 , C07D501/20 , C07D501/36 , C07D501/57
CPC分类号： C07D295/21 , C07C57/58 , C07C57/76 , C07D333/24
摘要： Novel cephalosporin antibiotic derivatives.
摘要翻译： 新型头孢菌素类抗生素衍生物。
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公开(公告)号：US07592466B2
公开(公告)日：2009-09-22
申请号：US10961362
申请日：2004-10-08
IPC分类号： C07D295/00 , C07D207/00
CPC分类号： C07D401/06 , C07D401/14 , C07D409/14 , C07D471/08 , C07D491/113
摘要： Compounds having the formula are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.
摘要翻译： 具有下式的化合物是血管发生抑制剂。 还公开了含有化合物的组合物，制备化合物的方法和使用该化合物的治疗方法。
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公开(公告)号：US20070032527A1
公开(公告)日：2007-02-08
申请号：US11537714
申请日：2006-10-02
申请人： Fortuna Haviv , Michael Bradley , Jurgen Dinges , Daryl Sauer , Jack Henkin
发明人： Fortuna Haviv , Michael Bradley , Jurgen Dinges , Daryl Sauer , Jack Henkin
IPC分类号： A61K31/455
CPC分类号： A61K31/455
摘要： Compounds having the formula are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.
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公开(公告)号：US20060194737A1
公开(公告)日：2006-08-31
申请号：US11418667
申请日：2006-05-05
申请人： Fortuna Haviv , Michael Bradley
发明人： Fortuna Haviv , Michael Bradley
CPC分类号： C07K7/06 , A61K38/00 , C07K14/515
摘要： Compounds of formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.
摘要翻译： 描述了可用于治疗由血管生成引起或加剧的病症的式（SEQ ID NO：1）的化合物。 还公开了包含这些化合物的药物组合物，使用这些化合物的治疗方法，以及抑制血管发生的方法。
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公开(公告)号：US07037897B2
公开(公告)日：2006-05-02
申请号：US10283813
申请日：2002-10-30
申请人： Fortuna Haviv , Michael F. Bradley
发明人： Fortuna Haviv , Michael F. Bradley
IPC分类号： A61K38/00
CPC分类号： C07K5/0821 , A61K38/06 , A61K38/07 , A61K38/08 , C07K5/0808 , C07K5/081 , C07K5/0815 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K7/02
摘要： Compounds of formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.
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50.发明授权3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists 失效3'，3'-N-bis-desmethyl-3'-N-环烷基红霉素衍生物作为LHRH拮抗剂公开(公告)号：US06387885B1
公开(公告)日：2002-05-14
申请号：US09140157
申请日：1998-08-26
申请人： Christopher R. Dalton , Milan Bruncko , Michele A. Kaminski , Lisa M. Frey , Daryl R. Sauer , Fortuna Haviv
发明人： Christopher R. Dalton , Milan Bruncko , Michele A. Kaminski , Lisa M. Frey , Daryl R. Sauer , Fortuna Haviv
IPC分类号： A61K3170
CPC分类号： A61K31/7048 , C07H17/08
摘要： Disclosed are 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.
摘要翻译： 公开了3'，3'-N-双 - 脱甲基-3'-N-环烷基-6-O-甲基-11-脱氧-11,12-环状氨基甲酸酯红霉素A衍生物，其是促黄体激素释放激素的拮抗剂 LHRH）。 还公开了包含该化合物的药物组合物，使用该化合物的方法及其制备方法。
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