摘要:
The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, A, Q, W and X are as defined in the description.These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.
摘要:
The present invention is concerned with substituted azole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. In particular, several of these compounds are potent and selective Flt-3 inhibitors or/and syk inhibitors.
摘要:
Methods are provided for detecting and optionally quantitating multiple analytes, including nucleic acid and/or polypeptide analytes, in particle-based assays that can be highly multiplexed. Compositions, systems, and kits related to the methods are also featured.
摘要:
The present application is directed to devices and methods for removing toner from a belt within an image forming apparatus. In one embodiment, the device includes a housing that forms an enclosed interior space. The housing may include an inlet that leads into the interior space. A blade may be positioned in proximity to the inlet to remove the toner from the belt and direct it into the inlet. An auger may be rotationally positioned within the interior space to move the toner along a longitudinal width of the device. An agitating member may be rotationally positioned within the interior space to move the toner from the inlet towards the auger. The agitating member may include a flexible arm that contacts against at least one of the blade and the auger during rotation.
摘要:
Methods are provided for detecting and optionally quantitating multiple analytes, including nucleic acid and/or polypeptide analytes, in particle-based assays that can be highly multiplexed. Compositions, systems, and kits related to the methods are also featured.
摘要:
In accordance with the invention a configurable electrical distribution system is provided for selectively connecting an electrical power source to load devices. The system comprises a panel and a plurality of switching devices mounted in the panel, each switching device for connection in a branch circuit to a load device for selectively delivering electrical power to the load device. A panel controller is mounted in the panel and is operatively connected to each of the switching devices. The panel controller comprises a programmed controller for controlling operation of the switching devices and a panel memory connected to the programmed controller storing configuration data relating to operation of the switching devices. A port is provided for operatively connecting an external memory device to the programmed controller. A user interface is operatively associated with the programmed controller to transfer configuration data between the external memory device and the panel memory.
摘要:
Embodiments of the invention may be used to generate an analysis model of a building for use in thermal modeling and other analyses. A method for generating a model for use in determining environmental requirements includes the steps of receiving a computer-aided design (CAD) model of a building design, parsing the CAD model to identify one or more rooms in the building design, and generating a description for each of the one or more rooms. The description of a given room specifies a set of geometric properties describing the given room. The method also includes the steps of determining an environmental requirement of the building design based on the descriptions generated for the one or more rooms and storing the results of the analysis and the determined environmental requirement for review.
摘要:
Methods and apparatus, including computer program products, for providing a physical computer aided design (CAD) model comprising a plurality of physical objects in a flow system. Each of the plurality of physical objects are joined at one or more physical linkages. An analytical model of the flow system is generated based on the one or more physical linkages. And one of the analytical model or the physical CAD model is automatically updated to reflect a change to the other.