DEVELOPMENT AND EVALUATION OF NOVEL CHINESE MATERIA MEDICA PREPARATIONS
    41.
    发明申请
    DEVELOPMENT AND EVALUATION OF NOVEL CHINESE MATERIA MEDICA PREPARATIONS 审中-公开
    新型中药材制剂的开发与评价

    公开(公告)号:US20120309700A1

    公开(公告)日:2012-12-06

    申请号:US13499864

    申请日:2010-08-24

    CPC分类号: G01N33/6875

    摘要: Nuclear receptor LXR is an important member of 49 nuclear receptors in human bodies and has irreplaceable regulatory effects on cholesterol and fat metabolisms. The regulation of the biological activity of LXR may have therapeutic effects to the conditions such as cardiovascular and cerebrovascular obstructions, non-insulin dependent hyperglycemia, immune function disorders, and central nerve functional degeneration. We have developed a group of novel Chinese materia medica preparations targeting nuclear receptor LXR by using a computer-simulated docking technology and a process for determining biological activities of human cells cultured ex vivo. The group of preparations are featured by simple ingredients, low costs, easy to prepare, etc. No significant adverse effects were found in initial acute toxicology analysis which was carried out using mice.

    摘要翻译: 核受体LXR是人体中49种核受体的重要成员,对胆固醇和脂肪代谢具有不可替代的调节作用。 对LXR的生物活性的调节可能对诸如心血管和脑血管障碍,非胰岛素依赖性高血糖症,免疫功能障碍和中枢神经功能退化等疾病具有治疗作用。 我们通过使用计算机模拟对接技术和用于测定离体培养的人类细胞的生物活性的方法开发了一组靶向核受体LXR的中药材制剂。 该组制剂以简单成分为特征,成本低,易于制备等。在使用小鼠进行的初始急性毒理学分析中未发现明显的不良反应。

    REQUEST CONTROLLING
    43.
    发明申请
    REQUEST CONTROLLING 有权
    请求控制

    公开(公告)号:US20120054451A1

    公开(公告)日:2012-03-01

    申请号:US13217398

    申请日:2011-08-25

    IPC分类号: G06F12/00 G06F12/14

    摘要: This invention provides a request controlling apparatus, processor and method. The request controlling apparatus is connected to a request storage unit and includes: a queue unit storing flag recording region configured to record a storing flag corresponding to a queue unit in the request storage unit, a comparing means configured to judge whether a incoming first queue unit corresponds to a same message as an already existing queue unit, where the already existing queue unit is in the request storage unit and a flag setting means is configured to set the storing flag corresponding to the already existing queue unit in the queue unit storing flag recording region, to indicate that a message state related to the already existing queue unit will not be stored if the first queue unit corresponds to the same message as in the already existing queue unit.

    摘要翻译: 本发明提供了一种请求控制装置,处理器和方法。 所述请求控制装置连接到请求存储单元,包括:队列单元,存储标记记录区域,被配置为在所述请求存储单元中记录与队列单元对应的存储标志;比较装置,被配置为判断进入的第一队列单元 对应于与现有的队列单元相同的消息,其中已经存在的队列单元在请求存储单元中,并且标志设置装置被配置为将对应于已经存在的队列单元的存储标志设置在队列单元存储标志记录中 指示如果第一队列单元对应于与已经存在的队列单元相同的消息,则与现有队列单元相关的消息状态将不被存储。

    Method for providing high performance scalable file I/O through persistent file domain and functional partitioning
    44.
    发明授权
    Method for providing high performance scalable file I/O through persistent file domain and functional partitioning 有权
    通过持久性文件域和功能分区提供高性能可扩展文件I / O的方法

    公开(公告)号:US07721009B2

    公开(公告)日:2010-05-18

    申请号:US11604162

    申请日:2006-11-22

    IPC分类号: G06F3/00

    CPC分类号: G06F17/30171 G06F17/30224

    摘要: A method for implementing large scale parallel file I/O processing includes steps of: separating processing nodes into compute nodes specializing in computation and I/O nodes (computer processors restricted to running I/O daemons); organizing the compute nodes and the I/O nodes into processing sets, the processing sets including: one dedicated I/O node corresponding to a plurality of compute nodes. I/O related system calls are received in the compute nodes then sent to the corresponding I/O nodes. The I/O related system calls are processed through a system I/O daemon residing in the I/O node. The plurality of compute nodes are evenly distributed across participating processing sets. Additionally, for collective I/O operations, compute nodes from each processing set are assigned as I/O aggregators to issue I/O requests to their corresponding I/O node, wherein the I/O aggregators are evenly distributed across the processing set. Additionally, a file domain is partitioned using a collective buffering technique wherein data is aggregated in memory prior to writing to a file; portions of the partitioned file domain are assigned to the processing sets.

    摘要翻译: 实现大规模并行文件I / O处理的方法包括以下步骤:将处理节点分为专用于计算和I / O节点的计算节点(限于运行I / O守护程序的计算机处理器); 将所述计算节点和所述I / O节点组织成处理集合,所述处理集包括:与多个计算节点对应的一个专用I / O节点。 在计算节点中接收到I / O相关的系统调用,然后发送到相应的I / O节点。 通过驻留在I / O节点中的系统I / O守护进程处理与I / O相关的系统调用。 多个计算节点在参与处理集合之间均匀分布。 此外,对于集体I / O操作,将来自每个处理集合的计算节点分配为I / O聚合器,以向其相应的I / O节点发出I / O请求,其中I / O聚合器均匀分布在整个处理集中。 此外,使用集体缓冲技术对文件域进行分区,其中在写入文件之前将数据聚集在存储器中; 分区文件域的一部分被分配给处理集。

    Method for providing high performance scalable file I/O through persistent file domain and functional partitioning
    46.
    发明申请
    Method for providing high performance scalable file I/O through persistent file domain and functional partitioning 有权
    通过持久性文件域和功能分区提供高性能可扩展文件I / O的方法

    公开(公告)号:US20080120435A1

    公开(公告)日:2008-05-22

    申请号:US11604162

    申请日:2006-11-22

    IPC分类号: G06F3/00

    CPC分类号: G06F17/30171 G06F17/30224

    摘要: A method for implementing large scale parallel file I/O processing includes steps of: separating processing nodes into compute nodes specializing in computation and I/O nodes (computer processors restricted to running I/O daemons); organizing the compute nodes and the I/O nodes into processing sets, the processing sets including: one dedicated I/O node corresponding to a plurality of compute nodes. I/O related system calls are received in the compute nodes then sent to the corresponding I/O nodes. The I/O related system calls are processed through a system I/O daemon residing in the I/O node. The plurality of compute nodes are evenly distributed across participating processing sets. Additionally, for collective I/O operations, compute nodes from each processing set are assigned as I/O aggregators to issue I/O requests to their corresponding I/O node, wherein the I/O aggregators are evenly distributed across the processing set. Additionally, a file domain is partitioned using a collective buffering technique wherein data is aggregated in memory prior to writing to a file; portions of the partitioned file domain are assigned to the processing sets.

    摘要翻译: 实现大规模并行文件I / O处理的方法包括以下步骤:将处理节点分为专用于计算和I / O节点的计算节点(限于运行I / O守护程序的计算机处理器); 将所述计算节点和所述I / O节点组织成处理集合,所述处理集包括:与多个计算节点对应的一个专用I / O节点。 在计算节点中接收到I / O相关的系统调用,然后发送到相应的I / O节点。 通过驻留在I / O节点中的系统I / O守护进程处理与I / O相关的系统调用。 多个计算节点在参与处理集合之间均匀分布。 此外,对于集体I / O操作,将来自每个处理集合的计算节点分配为I / O聚合器,以向其相应的I / O节点发出I / O请求,其中I / O聚合器均匀分布在整个处理集中。 此外,使用集体缓冲技术对文件域进行分区,其中在写入文件之前将数据聚集在存储器中; 分区文件域的一部分被分配给处理集。