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公开(公告)号：US07842663B2
公开(公告)日：2010-11-30
申请号：US12012652
申请日：2008-02-04
Applicant: John Knopf , Jasbir Seehra , Ravindra Kumar
Inventor： John Knopf , Jasbir Seehra , Ravindra Kumar
IPC: A61K38/00 , A61K38/16 , C07K14/00 , C07K14/705 , C07K14/71
CPC classification number: C07K14/71 , A61K38/00 , C07K14/705 , C07K14/72 , C07K16/18 , C07K2319/30 , C07K2319/70
Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
Abstract translation: 在某些方面，本发明提供用于调节（促进或抑制）组织如骨，软骨，肌肉，脂肪和/或神经元组织的生长的组合物和方法。 本发明还提供筛选调节ActRIIB蛋白和/或ActRIIB配体的活性的化合物的方法。 本文提供的组合物和方法可用于治疗与ActRIIB蛋白和/或ActRIIB配体的异常活性相关的疾病。
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42.发明申请METHODS, SYSTEMS AND/OR APPARATUS RELATING TO FREQUENCY-TUNED TURBINE BLADES 审中-公开与频率调节涡轮叶片相关的方法，系统和/或装置公开(公告)号：US20100166550A1
公开(公告)日：2010-07-01
申请号：US12347329
申请日：2008-12-31
Applicant: Siddaraja M. Devangada , Ravindra Kumar
Inventor： Siddaraja M. Devangada , Ravindra Kumar
CPC classification number: F01D5/16 , F01D5/26 , F01D9/041 , Y10T29/49336
Abstract: A method of tuning a compressor stator blade, having a base portion and an airfoil portion, to achieve a desired natural frequency, comprising: a) identifying the natural frequency of the compressor stator blade; b) determining a different target natural frequency for the compressor stator blade; and c) removing material from at least one of the side surfaces of the base portion of the compressor stator blade in an amount and in a configuration that achieves the target natural frequency.
Abstract translation: 一种调节压缩机定子叶片的方法，所述压缩机定子叶片具有基部和翼型部分，以实现期望的固有频率，包括：a）识别压缩机定子叶片的固有频率; b）确定压缩机定子叶片的不同目标固有频率; 以及c）以达到目标固有频率的量和配置从所述压缩机定子叶片的基部的至少一个侧表面去除材料。
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43.发明申请公开(公告)号：US20090311272A1
公开(公告)日：2009-12-17
申请号：US12434598
申请日：2009-05-01
Applicant: Asya Grinberg , John Knopf , Ravindra Kumar , Robert S. Pearsall , Jasbir Seehra , Kristian Pietras
Inventor： Asya Grinberg , John Knopf , Ravindra Kumar , Robert S. Pearsall , Jasbir Seehra , Kristian Pietras
IPC: A61K39/395 , C07K16/30 , A61P35/00
CPC classification number: C07K16/2896 , A61K2039/505 , C07K14/71 , C07K16/40 , C07K2317/76 , C07K2319/32
Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
Abstract translation: 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 此外，本公开表明ALK1的抑制剂可用于增加血管化组织（包括肿瘤和视网膜）中的周细胞覆盖。 本公开还鉴定了ALK1的配体，并证明这些配体具有促血管生成活性，并描述了抑制受体 - 配体相互作用的抗体。
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公开(公告)号：US07563760B2
公开(公告)日：2009-07-21
申请号：US09935144
申请日：2001-08-21
Applicant: Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
Inventor： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
IPC: A61K38/00 , A61K39/395
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , C07K14/4703 , C07K14/51 , C07K14/52 , C07K14/5431 , C07K14/705 , C07K16/2851 , C07K16/2854 , C07K19/00 , C07K2319/00 , C07K2319/24 , C12N9/10 , C12N9/1051 , C12N9/6454 , C12N2770/36222
Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
Abstract translation: 公开了一种新型P-选择素配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。 还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。 还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。
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公开(公告)号：US20090104180A1
公开(公告)日：2009-04-23
申请号：US12167663
申请日：2008-07-03
Applicant: Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
Inventor： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
IPC: A61K39/395 , A01N1/02 , A61K38/16 , A61K38/43 , A61K38/10
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , C07K14/4703 , C07K14/51 , C07K14/52 , C07K14/5431 , C07K14/705 , C07K16/2851 , C07K16/2854 , C07K19/00 , C07K2319/00 , C07K2319/24 , C12N9/10 , C12N9/1051 , C12N9/6454 , C12N2770/36222
Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
Abstract translation: 公开了一种新型P-选择素配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。 还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。 还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。
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Patent Agency Ranking
公开(公告)号：US20090028883A1
公开(公告)日：2009-01-29
申请号：US12167705
申请日：2008-07-03
Applicant: Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
Inventor： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
IPC: A61K39/395 , C07K14/47 , A61K38/17 , A61P29/00 , C07K16/18
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , C07K14/4703 , C07K14/51 , C07K14/52 , C07K14/5431 , C07K14/705 , C07K16/2851 , C07K16/2854 , C07K19/00 , C07K2319/00 , C07K2319/24 , C12N9/10 , C12N9/1051 , C12N9/6454 , C12N2770/36222
Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
Abstract translation: 公开了一种新型P-选择素配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。 还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。 还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。
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公开(公告)号：US20080280327A1
公开(公告)日：2008-11-13
申请号：US12167680
申请日：2008-07-03
Applicant: Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
Inventor： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , C07K14/4703 , C07K14/51 , C07K14/52 , C07K14/5431 , C07K14/705 , C07K16/2851 , C07K16/2854 , C07K19/00 , C07K2319/00 , C07K2319/24 , C12N9/10 , C12N9/1051 , C12N9/6454 , C12N2770/36222
Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
Abstract translation: 公开了一种新型P-选择素配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。 还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。 还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。
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48.发明申请Platelet glycoprotein Ib alpha variant fusion polypeptides and methods of use thereof 失效血小板糖蛋白Ibα变体融合多肽及其使用方法公开(公告)号：US20050089888A1
公开(公告)日：2005-04-28
申请号：US10868371
申请日：2004-06-14
Applicant: Gray Shaw , Dianne Sako , Ravindra Kumar , Jin Xu
Inventor： Gray Shaw , Dianne Sako , Ravindra Kumar , Jin Xu
IPC: A61K38/00 , A61K38/36 , C07K14/705 , C07K14/745 , C12N15/12 , C12Q1/68 , C07H21/04 , C12N9/22
CPC classification number: C07K14/705 , A61K38/00 , C07K2319/00
Abstract: The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
Abstract translation: 本发明提供了用于治疗或预防血管相关疾病的组合物和方法。
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公开(公告)号：US5869307A
公开(公告)日：1999-02-09
申请号：US984246
申请日：1997-12-03
Applicant: Francis Sullivan , Ronald Kriz , Ravindra Kumar
Inventor： Francis Sullivan , Ronald Kriz , Ravindra Kumar
CPC classification number: C12N9/88
Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.
Abstract translation: 本发明提供了一种新的GDP-甘露糖4,6-脱水酶。
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公开(公告)号：US5728568A
公开(公告)日：1998-03-17
申请号：US753233
申请日：1996-11-22
Applicant: Francis Sullivan , Ronald Kriz , Ravindra Kumar
Inventor： Francis Sullivan , Ronald Kriz , Ravindra Kumar
CPC classification number: C12N9/88
Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.
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