公开(公告)号：US07940966B2

公开(公告)日：2011-05-10

申请号：US10530447

申请日：2003-11-25

申请人： Zengpin Yu ,  Shih-Ping Wang

发明人： Zengpin Yu ,  Shih-Ping Wang

IPC分类号： G06K9/00

CPC分类号： G06K9/00 ,  A61B6/502 ,  A61B6/5235 ,  A61B6/5247 ,  A61B8/0825 ,  A61B8/4405 ,  A61B8/5238 ,  G06F19/00 ,  G06Q10/06311 ,  G06Q10/063116 ,  G06Q50/22 ,  G06Q50/24

摘要： A system, computer program product, and related methods are described for obtaining, processing, and/or and archiving full-field breast image data, such as full-field breast ultrasound (FFBU) data, in a manner that promotes ready integration with current x-ray mammogram-based breast cancer screening methodologies, and which can alternatively be used to support a full-field-only environment. Two-dimensional thick-slice images computed from a three-dimensional data volume are used to facilitate efficient archiving for a breast imaging session, the two-dimensional thick-slice images corresponding to slab-like subvolumes of the breast. Clinician data overload problems that can arise from the existence of large amounts of three-dimensional full-field breast image data are reduced. Archive space is also preserved while still providing sufficient information data for future reference purposes. Related adjunctive full-field workflow methods are also described. The described embodiments are applicable to FFBU imaging and other full-field breast imaging modalities such as MRI, CT, PET, and others.

摘要翻译： 描述了用于获得，处理和/或归档全场乳房图像数据（例如全场乳房超声（FFBU）数据）的系统，计算机程序产品和相关方法，以促进与当前的现场集成的方式 基于X射线乳腺X线摄影的乳腺癌筛查方法，可替代地可用于支持全场仅有的环境。 使用从三维数据体积计算的二维厚片图像来促进乳房成像会话的有效归档，对应于乳房的板状子体积的二维厚片图像。 减少了由存在大量三维全场乳房图像数据引起的临床医生数据过载问题。 存档空间也得到保留，同时仍然提供足够的信息数据以备将来参考。 还描述了相关的辅助全字段工作流程方法。 所描述的实施例可应用于FFBU成像和其他全场乳房成像模式，例如MRI，CT，PET等。

公开(公告)号：US20100331699A1

公开(公告)日：2010-12-30

申请号：US10560200

申请日：2004-06-18

申请人： Zengpin Yu ,  Danhua Zhao ,  Thomas P. Neff ,  Wei Zhang ,  Shih-Ping Wang

发明人： Zengpin Yu ,  Danhua Zhao ,  Thomas P. Neff ,  Wei Zhang ,  Shih-Ping Wang

IPC分类号： A61B8/14

CPC分类号： A61B8/4477 ,  A61B8/0825 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/5238 ,  Y10T29/49005

摘要： A modular, flexible architecture for offering full-field breast ultrasound (FFBU) functionality and general-purpose ultrasound functionality in a single system is described. A conventional, general-purpose ultrasound system (202) is modified with an FFBU toolkit to create a dual-capability ultrasound system (200), the dual-capability ultrasound system (200) being able to accommodate both general-purpose ultrasound functionality and FFBU functionality, using a single ultrasound engine (112). Among other advantages, real-world clinical environments may enjoy cost savings for initial system procurement, space savings on clinic floors, easier and less expensive system upgrades, and the ability to use a single system and user interface for both FFBU screening and for follow-up diagnosis, biopsy, etc. Among other advantages from an ultrasound manufacturer's perspective are the ability to quickly and/or more easily come to market with an FFBU-related offering by modifying their existing general-purpose ultrasound systems (202) with FFBU toolkits to quickly create dual-capability ultrasound systems (200).

摘要翻译： 描述了在单个系统中提供全场乳房超声（FFBU）功能和通用超声功能的模块化，灵活的架构。 传统的通用超声系统（202）用FFBU工具包修改以创建双能力超声系统（200），双能力超声系统（200）能够容纳通用超声功能和FFBU 功能，使用单个超声引擎（112）。 除了其他优点之外，现实世界的临床环境可以节省初始系统采购成本，临床楼层节省空间，更便宜和更便宜的系统升级，以及使用单个系统和用户界面进行FFBU筛选和跟踪的功能， 诊断，活检等。超声波制造商的观点还有其他优点，即通过使用FFBU工具包修改现有的通用超声波系统（202），通过与FFBU相关的产品快速和/或更容易上市。 快速创建双功能超声系统（200）。

公开(公告)号：US07828732B2

公开(公告)日：2010-11-09

申请号：US12479468

申请日：2009-06-05

申请人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao

发明人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao

IPC分类号： A61B8/00

CPC分类号： A61B6/463 ,  A61B6/4423 ,  A61B6/502 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/0825 ,  A61B8/406 ,  A61B8/462 ,  A61B8/463 ,  A61B8/464 ,  A61B8/465 ,  A61B8/467 ,  A61B8/469 ,  A61B8/5238 ,  A61B8/565 ,  G06F19/00

摘要： An adjunctive ultrasound mammography system and associated methods are described, comprising a scanning apparatus for facilitating standardized, repeatable breast ultrasound scans, and further comprising an adjunctive ultrasound display apparatus configured for fast, intuitive viewing of adjunctive ultrasound data concurrently with x-ray mammogram information. In one preferred embodiment, thick-slice ultrasound images are displayed near an x-ray mammogram such that a screening radiologist can quickly view the thick-slice images for assistance in interpreting the x-ray mammogram. Methods for concurrently acquiring and displaying vibrational resonance image (VDI) data are described. Computer-aided diagnosis (CAD) algorithms that incorporate acoustically-based feature vectors are described, the feature vectors including lateral shadow metrics, vertical shadow metrics, posterior enhancement metrics, and VDI-based metrics. Algorithms are also described that combine x-ray mammogram CAD results with adjunctive ultrasound CAD results without requiring complex image registrations therebetween. Many of the practical, economic, and political barriers to acceptance and integration of ultrasound mammography into existing mass breast cancer screening environments are mitigated.

摘要翻译： 描述了辅助超声乳腺摄影系统和相关方法，其包括用于促进标准化，可重复的乳房超声扫描的扫描装置，并且还包括辅助超声显示装置，其配置为与X射线乳腺X线照相信息同时快速，直观地观看辅助超声数据。 在一个优选实施例中，在x射线乳房X线照片附近显示厚片超声图像，使得筛选放射科医师可以快速查看厚切片图像以辅助解释X射线乳腺X线照片。 描述了同时获取和显示振动共振图像（VDI）数据的方法。 描述了包含声学特征向量的计算机辅助诊断（CAD）算法，其特征向量包括横向阴影度量，垂直阴影度量，后验增强度量和基于VDI的度量。 还描述了将x射线乳房X线照片CAD结果与辅助超声CAD结果相结合的算法，而不需要它们之间的复杂图像注册。 超声乳房X线照相术在现有的大规模乳腺癌筛查环境中接受和整合的许多实际，经济和政治障碍得到缓解。

公开(公告)号：US20100076311A1

公开(公告)日：2010-03-25

申请号：US12441975

申请日：2007-09-21

申请人： Laszlo Tabar ,  Shih-Ping Wang ,  Tor C. Anderson ,  Jiayu Chen

发明人： Laszlo Tabar ,  Shih-Ping Wang ,  Tor C. Anderson ,  Jiayu Chen

IPC分类号： A61B8/14 ,  G06K9/00

CPC分类号： A61B8/0825 ,  A61B8/523

摘要： Systems, methods, and related computer program products for acquiring, processing, and displaying breast ultrasound information are described. In one preferred embodiment, a three-dimensional data volume of a sonographic property of a chestwardly compressed breast is acquired, and the data volume is processed to generate a plurality of two-dimensional coronal thick-slice images. Each coronal thick-slice image is representative of the sonographic property within a thick-slice subvolume of the breast substantially parallel to a coronal plane. The thick-slice subvolume has a thickness selected for optimal viewing of terminal ductal lobular unit (TDLU) patterns in a display of the thick-slice images.

摘要翻译： 描述了用于获取，处理和显示乳房超声信息的系统，方法和相关的计算机程序产品。 在一个优选实施例中，获取胸部压缩乳房的超声波特性的三维数据体积，并处理数据体积以产生多个二维冠状厚片图像。 每个冠状厚片图像代表基本上平行于冠状面的乳房的厚切片子体积内的超声波特性。 厚片子体积具有选择用于在厚片图像的显示器中最佳观看末端导管小叶单元（TDLU）图案的厚度。

公开(公告)号：US07597663B2

公开(公告)日：2009-10-06

申请号：US10305936

申请日：2002-11-27

申请人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao ,  Nico Karssemeijier

发明人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao ,  Nico Karssemeijier

IPC分类号： A61B8/00

CPC分类号： A61B8/5215 ,  A61B6/463 ,  A61B6/502 ,  A61B6/5241 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/0825 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/463 ,  A61B8/464 ,  A61B8/465 ,  A61B8/466 ,  A61B8/467 ,  A61B8/5238 ,  A61B8/565 ,  G06F19/00

摘要： An adjunctive ultrasound mammography system and associated methods are described comprising an adjunctive ultrasound display configured for quick, intuitive, interactive viewing of data derived from volumetric ultrasound scans, the data being displayed near a conventional x-ray mammogram display. Preferred embodiments for navigating among a thick-slice image array, a selected enlarged thick-slice image, and planar ultrasound views are described, including a preferred embodiment in which the planar ultrasound views are updated in real time as a cursor is moved across an active thick-slice image. In one preferred embodiment the thick-slice images are inverted prior to display, with non-breast areas of the image preferably segmented out and reset to dark. The inverted thick-slice images are of more familiar significance to radiologists having years of expertise in analyzing conventional x-ray mammograms. For example, the inverted thick-slice images allow benign features to be more easily dismissed as compared to non-inverted thick-slice images. Preferred embodiments for computing thick-slice image values from the volumetric scan data are also described that emphasize larger mass lesions in the resulting thick-slice images, and that compensate for mass lesions that straddle thick-slice region borders.

摘要翻译： 描述了一种辅助超声乳腺摄影系统和相关方法，其包括辅助性超声显示器，其配置用于快速，直观，互动地观看从体积超声扫描获得的数据，该数据显示在常规x射线乳房X线照片显示附近。 描述了用于在厚片图像阵列，选定的放大的厚片图像和平面超声波视图之间导航的优选实施例，包括优选实施例，其中当光标移动到活动的时候，平面超声波视图被实时地更新 厚片图像。 在一个优选实施例中，厚片图像在显示之前被反转，其中图像的非乳房区域优选地被分割出并且重新设置为暗。 倒置的厚片图像对于在分析常规x射线乳房X线照片方面具有多年专业知识的放射科医师更为重要。 例如，与非倒置厚片图像相比，反向厚片图像允许更容易地解除良性特征。 还描述了用于从体积扫描数据计算厚片图像值的优选实施例，其强调所得厚片图像中的较大质量损伤，并补偿跨越厚片区域边界的质量损伤。

公开(公告)号：US20060173303A1

公开(公告)日：2006-08-03

申请号：US10530447

申请日：2003-11-25

申请人： Zengpin Yu ,  Shih-Ping Wang

发明人： Zengpin Yu ,  Shih-Ping Wang

IPC分类号： A61B8/00

CPC分类号： G06K9/00 ,  A61B6/502 ,  A61B6/5235 ,  A61B6/5247 ,  A61B8/0825 ,  A61B8/4405 ,  A61B8/5238 ,  G06F19/00 ,  G06Q10/06311 ,  G06Q10/063116 ,  G06Q50/22 ,  G06Q50/24

摘要： A system, computer program product, and related methods are described for obtaining, processing, and/or and archiving full-field breast image data, such as full-field breast ultrasound (FFBU) data, in a manner that promotes ready integration with current x-ray mammogram-based breast cancer screening methodologies, and which can alternatively be used to support a full-field-only environment, Two-dimensional thick-slice images computed from a three-dimensional data volume are used to facilitate efficient archiving for a breast imaging session, the two-dimensional thick-slice images corresponding to slab-like subvolumes of the breast. Clinician data overload problems that can arise from the existence of large amounts of three-dimensional full-field breast image data are reduced. Archive space is also preserved while still providing sufficient information data for future reference purposes. Related adjunctive full-field workflow methods are also described. The described embodiments are applicable to FFBU imaging and other full-field breast imaging modalities such as MRI, CT, PET, and others.

摘要翻译： 描述了用于获得，处理和/或归档全场乳房图像数据（例如全场乳房超声（FFBU）数据）的系统，计算机程序产品和相关方法，以促进与当前的现场集成的方式 基于x射线乳腺X线摄影的乳腺癌筛查方法，可替代地可用于支持全场仅环境，使用从三维数据量计算的二维厚片图像来促进有效的归档 乳房成像会话，对应于乳房的板状子体积的二维厚片图像。 减少了由存在大量三维全场乳房图像数据引起的临床医生数据过载问题。 存档空间也得到保留，同时仍然提供足够的信息数据以备将来参考。 还描述了相关的辅助全字段工作流程方法。 所描述的实施例可应用于FFBU成像和其他全场乳房成像模式，例如MRI，CT，PET等。

公开(公告)号：US20060153434A1

公开(公告)日：2006-07-13

申请号：US10536623

申请日：2003-11-26

申请人： Shih-Ping Wang

发明人： Shih-Ping Wang

IPC分类号： G06K9/00

CPC分类号： A61B6/463 ,  A61B5/055 ,  A61B6/00 ,  A61B6/032 ,  A61B6/502 ,  A61B6/5205 ,  G06F19/321 ,  G06T19/00 ,  G06T2210/41 ,  G06T2219/028 ,  G16H50/20

摘要： A method and associated systems for processing and displaying three-dimensional medical imaging data of a subject anatomical volume is described in which a plurality of thick-slice images is computed and displayed each thick-slice image corresponding to a thick-slice or slab-like subvolume of the anatomical volume substantially parallel to a standard x-ray view plane for that anatomical volume. The thick-slice or slab-like subvolumes have a thickness generally related to a lesion size to be detected and/or examined. The described thick-slice processing and display is generally applicable for any anatomical volume (e.g.,chest, head, abdomen, breast, etc.) having associated standard x-ray views (e.g., PA, lateral. CC, MLO, etc.) that is also amenable to one or more three-dimensional imaging modalities (e.g., MRI, CT, SPECT, PET, ultrasound, etc.). According to one preferred embodiment in which the particular three-dimensional imaging modality is CT imaging, thick-slice processing and display is used to facilitate reduced screening radiation dosage.

摘要翻译： 描述了用于处理和显示对象解剖体积的三维医学成像数据的方法和相关联的系统，其中计算多个厚片图像并且显示对应于厚切片或板状的每个厚片图像 该解剖体积的子体积基本上平行于该解剖体积的标准X射线视野平面。 厚切片或板状子体积具有通常与待检测和/或检查的病变大小有关的厚度。 所描述的厚切片处理和显示通常适用于具有相关联的标准x射线视图（例如，PA，侧向CC，MLO等）的任何解剖体积（例如，胸部，头部，腹部，乳房等） 这也适用于一种或多种三维成像模式（例如，MRI，CT，SPECT，PET，超声等）。 根据其中特定三维成像模式是CT成像的一个优选实施例，使用厚切片处理和显示来促进减少的筛选辐射剂量。

公开(公告)号：US06695786B2

公开(公告)日：2004-02-24

申请号：US10100649

申请日：2002-03-18

申请人： Shih-Ping Wang ,  Shengtz Lin ,  Siqing Zhang ,  Donald Chin ,  Karen D. Maroc

发明人： Shih-Ping Wang ,  Shengtz Lin ,  Siqing Zhang ,  Donald Chin ,  Karen D. Maroc

IPC分类号： A61B814

CPC分类号： A61B8/0841 ,  A61B8/0833 ,  A61B8/587 ,  A61B17/3403 ,  A61B34/72 ,  A61B90/50 ,  A61B2017/3405 ,  A61B2017/3411 ,  A61B2017/3413

摘要： An instrument guide is described for mounting an invasive instrument such as a biopsy needle to an imaging probe, controlling its position, monitoring its position, and/or predictively displaying its position on a user display of the medical imaging system. A plurality of substantially rigid segments are hingeably connected to the probe, to an instrument handle, and to each other such that movement of the biopsy needle is restricted to within the imaged plane. However, substantial freedom of movement within the imaged plane is provided such that the instrument may be inserted into the patient over a wide range of angles. In one preferred embodiment, angle detectors are provided at each segment intersection and measurements provided for computing and displaying the instrument position and orientation on the user display. The instrument guide/position monitor is preferably made with low-cost components such that it is disposable after a single use. A predictive user display is provided in which the throw of a spring-loaded instrument is shown on the user display, the throw corresponding to the space that the instrument will occupy after a spring trigger is activated.

摘要翻译： 描述了用于将诸如活检针的入侵器械安装到成像探针，控制其位置，监视其位置和/或预测性地在医疗成像系统的用户显示器上显示其位置的仪器指南。 多个基本上刚性的部分可铰接地连接到探针，仪器把手和彼此，使得活检针的运动被限制在成像平面内。 然而，提供成像平面内的实质运动自由度，使得仪器可以在宽范围的角度上插入到患者体内。 在一个优选实施例中，角度检测器设置在每个段交叉点处，并且提供用于在用户显示器上计算和显示仪器位置和姿态的测量结果。 仪器导向/位置监视器优选地由低成本部件制成，使得它在一次使用之后是一次性的。 提供了一种预测用户显示，其中在用户显示器上显示弹簧加载的仪器的投掷，对应于在弹簧触发器被激活之后仪器将占据的空间的投掷。

公开(公告)号：US06628815B2

公开(公告)日：2003-09-30

申请号：US10010554

申请日：2001-11-02

申请人： Shih-Ping Wang

发明人： Shih-Ping Wang

IPC分类号： G06K900

CPC分类号： G06T7/0012 ,  G06F19/00 ,  G06F19/321 ,  G06T5/009 ,  G06T5/40 ,  G06T5/50 ,  G06T2207/10116 ,  G06T2207/30068 ,  G16H15/00 ,  G16H40/63 ,  G16H50/20 ,  H05G1/60

摘要： An x-ray system acquires an initial low-contrast, wide latitude (G=2.5, or G=2 or less) x-ray image of a breast. A processing system automatically finds suspected abnormalities in the breast by processing the low contrast initial image, and then automatically converts the initial x-ray image to a high-contrast, narrow latitude image at the locations of the found abnormalities to thereby facilitate diagnosis and patient care. The technology includes effective ways to produce, process and display the various images, and can be extended to other types of images.

公开(公告)号：US06266435B1

公开(公告)日：2001-07-24

申请号：US09179205

申请日：1998-10-27

申请人： Shih-Ping Wang

发明人： Shih-Ping Wang

IPC分类号： G06K900

CPC分类号： G06T5/50 ,  G06F19/00 ,  G06F19/321 ,  G06K2209/053 ,  G06T7/0012 ,  G06T2207/10116 ,  G06T2207/30068 ,  G16H15/00 ,  G16H40/63 ,  G16H50/20 ,  H05G1/60

摘要： A computer-aided diagnostic (CAD) method and system provide image annotation information that can include an assessment of the probability, likelihood or predictive value of the CAD-detected suspected abnormalities as an additional aid to the radiologist. More specifically, probability values, in numerical form and/or analog form, are added to the locational markers of the CAD-detected suspected abnormalities. The task of a physician using a CAD system is believed to be made easier by displaying two different markers representing different probability thresholds. An additional threshold can be used to display “extra view markers” as an additional aid or guide to the radiologic technician to take extra views of a patient before the patient is released or discharged. A control device is added to allow the user to select and vary the probability threshold for the display of locational markers.

摘要翻译： 计算机辅助诊断（CAD）方法和系统提供图像注释信息，其可以包括对CAD检测到的可疑异常的概率，似然性或预测值的评估，作为对放射科医生的额外辅助。 更具体地，数字形式和/或模拟形式的概率值被添加到CAD检测到的疑似异常的位置标记中。 通过显示表示不同概率阈值的两个不同标记，认为使用CAD系统的医师的任务变得更容易。 额外的阈值可用于显示“额外视图标记”作为放射技术人员在患者被释放或排出之前对病人进行额外看法的额外辅助或指导。 添加控制装置以允许用户选择和改变用于显示位置标记的概率阈值。