公开(公告)号：US20200216556A1

公开(公告)日：2020-07-09

申请号：US16714566

申请日：2019-12-13

Applicant: The Regents of the University of California

Inventor： Bin Liu

IPC: C07K16/30 ,  C07K16/28 ,  A61K47/68 ,  G01N33/68 ,  C12N15/10 ,  G01N33/574 ,  C07K16/00 ,  A61K49/00 ,  A61K45/06

Abstract: Methods are provided for identifying and selecting antibodies that are internalized into cells via the macropinocytosis pathway. Additionally antibodies that are internalized via this pathway are provided as well as immunoconjugates comprising such antibodies.

公开(公告)号：US10479839B2

公开(公告)日：2019-11-19

申请号：US15418588

申请日：2017-01-27

Applicant: The Regents of the University of California

Inventor： Bin Liu ,  James D. Marks

IPC: C07K16/30 ,  A61K39/00 ,  A61K39/395 ,  A61K51/10 ,  C07K16/28 ,  C07K16/18 ,  G01N33/574 ,  C07K16/00 ,  G01N33/68 ,  G01N33/50

Abstract: This invention provides a method that allows selection of antibodies against cells (e.g., tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, a panel of phage antibodies was generated that targets clinically represented prostate cancer antigens.

公开(公告)号：US20190276553A1

公开(公告)日：2019-09-12

申请号：US16348135

申请日：2017-11-10

Applicant: The Regents of the University of California

Inventor： Bin Liu ,  Daniel W. Sherbenou ,  Blake T. Aftab ,  Yang Su ,  Christopher R. Behrens

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  C12Q1/6886 ,  A61K47/68

Abstract: Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

公开(公告)号：US09593162B2

公开(公告)日：2017-03-14

申请号：US14486943

申请日：2014-09-15

Applicant: The Regents of the University of California

Inventor： Bin Liu ,  James D. Marks

IPC: C07K16/30 ,  C07K16/18 ,  A61K51/10 ,  C07K16/28 ,  G01N33/574

CPC classification number: C07K16/3069 ,  A61K51/1072 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/18 ,  C07K16/2803 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/77 ,  G01N33/5044 ,  G01N33/57434 ,  G01N33/6845 ,  G01N33/6854

Abstract: This invention provides a method that allows selection of antibodies against cells (e.g., tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, a panel of phage antibodies was generated that targets clinically represented prostate cancer antigens.

Abstract translation: 本发明提供允许使用激光捕获显微切割原位选择针对细胞（例如肿瘤细胞）的抗体的方法。 通过将抗体选择限于内化表位的结合物，产生一组靶向临床表现的前列腺癌抗原的噬菌体抗体。